Factors and Prognosis of Obstructive Pyelonephritis Patients

NCT06299215 | Completed

• 1 other identifier: APHP240044
• Study Type: observational
• Target: 575
• Locations: 1 country
• Sites: 1

Brief Summary

Acute obstructive pyelonephritis is a condition with a high risk of complications and may require admission to the intensive care unit. Most of the available data on this condition comes from small, retrospective, single-centre series. To date, no large-scale study has examined the factors associated with the prognosis of patients admitted to intensive care for acute obstructive pyelonephritis. The aim of this study is to describe the population and prognosis of patients admitted to the intensive care unit for the management of acute obstructive pyelonephritis, and to identify factors associated with a poor prognosis in these patients.

Conditions

Pyelonephritis; Prognostic

Keywords

acute kidney injury; renal remplacement therapy; hemodialysis; acute respiratory distress; hemodynamic failure

Outcome Measures

Primary Outcomes (1)

• The primary endpoint will be a combined endpoint of death, and/or stage 3 AKI ( KDIGO classification), and/or non-recovery of renal function.

  up to 30 days after admission to intensive care

Secondary Outcomes (12)

• Death

  up to 30 days after admission to intensive care

• Stage 3 Acute kidney injury (KDIGO classification)

  up to 30 days after admission to intensive care

• failure to recover renal function

  up to 30 days after admission to intensive care .

• the incidence of acute renal failure defined by KDIGO 1

  up to 30 days after admission to intensive care

• the incidence of acute renal failure defined by KDIGO 2 and 3

  up to 30 days after admission to intensive care

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients meeting the eligibility criteria over the period 2015-2022 will be included in the study.

You may qualify if:

• Patients over 18 years of age
• Hospitalized in intensive care for management of acute obstructive pyelonephritis
• Patients affiliated to a Social Security System

You may not qualify if:

• Pregnancy
• Opposition to data use
• Persons under legal protection (curatorship, guardianship), legal safeguards

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead

Study Sites (1)

Hospital Saint Louis

Paris, 75010, France

Location

Related Publications (10)

• Kakinoki H, Tobu S, Kakinoki Y, Udo K, Uozumi J, Noguchi M. Risk Factors for Uroseptic Shock in Patients with Urolithiasis-Related Acute Pyelonephritis. Urol Int. 2018;100(1):37-42. doi: 10.1159/000481801. Epub 2017 Oct 24.

  PMID: 29065405 BACKGROUND

• Liang X, Huang J, Xing M, He L, Zhu X, Weng Y, Guo Q, Zou W. Risk factors and outcomes of urosepsis in patients with calculous pyonephrosis receiving surgical intervention: a single-center retrospective study. BMC Anesthesiol. 2019 May 1;19(1):61. doi: 10.1186/s12871-019-0729-3.

  PMID: 31039739 BACKGROUND

• Yamamoto Y, Fujita K, Nakazawa S, Hayashi T, Tanigawa G, Imamura R, Hosomi M, Wada D, Fujimi S, Yamaguchi S. Clinical characteristics and risk factors for septic shock in patients receiving emergency drainage for acute pyelonephritis with upper urinary tract calculi. BMC Urol. 2012 Mar 13;12:4. doi: 10.1186/1471-2490-12-4.

  PMID: 22413829 BACKGROUND

• Baboudjian M, Gondran-Tellier B, Di Bisceglie M, Abdallah R, Michel F, Sichez PC, Al-Balushi K, Akiki A, Gaillet S, Delaporte V, Karsenty G, Lechevallier E, Guieu R, Boissier R. The prognostic value of serum procalcitonin in acute obstructive pyelonephritis. World J Urol. 2021 May;39(5):1583-1589. doi: 10.1007/s00345-020-03353-2. Epub 2020 Jul 15.

  PMID: 32671605 BACKGROUND

• Lee SH, Choi T, Choi J, Yoo KH. Differences between Risk Factors for Sepsis and Septic Shock in Obstructive Urolithiasis. J Korean Med Sci. 2020 Nov 9;35(43):e359. doi: 10.3346/jkms.2020.35.e359.

  PMID: 33169555 BACKGROUND

• Yamamichi F, Shigemura K, Kitagawa K, Fujisawa M. Comparison between non-septic and septic cases in stone-related obstructive acute pyelonephritis and risk factors for septic shock: A multi-center retrospective study. J Infect Chemother. 2018 Nov;24(11):902-906. doi: 10.1016/j.jiac.2018.08.002. Epub 2018 Aug 30.

  PMID: 30174285 BACKGROUND

• Tambo M, Okegawa T, Shishido T, Higashihara E, Nutahara K. Predictors of septic shock in obstructive acute pyelonephritis. World J Urol. 2014 Jun;32(3):803-11. doi: 10.1007/s00345-013-1166-4. Epub 2013 Sep 15.

  PMID: 24037335 BACKGROUND

• Srougi V, Moscardi PR, Marchini GS, Berjeaut RH, Torricelli FC, Mesquita JLB, Srougi M, Mazzucchi E. Septic Shock Following Surgical Decompression of Obstructing Ureteral Stones: A Prospective Analysis. J Endourol. 2018 May;32(5):446-450. doi: 10.1089/end.2017.0896. Epub 2018 Mar 20.

  PMID: 29439607 BACKGROUND

• Kamei J, Sugihara T, Yasunaga H, Matsui H, Sasabuchi Y, Fujimura T, Homma Y, Kume H. Impact of early ureteral drainage on mortality in obstructive pyelonephritis with urolithiasis: an analysis of the Japanese National Database. World J Urol. 2023 May;41(5):1365-1371. doi: 10.1007/s00345-023-04375-2. Epub 2023 Mar 22.

  PMID: 36947175 BACKGROUND

• Kellum JA, Zarbock A, Nadim MK. What endpoints should be used for clinical studies in acute kidney injury? Intensive Care Med. 2017 Jun;43(6):901-903. doi: 10.1007/s00134-017-4732-1. Epub 2017 Mar 2. No abstract available.

  PMID: 28255614 BACKGROUND

MeSH Terms

Conditions

Pyelonephritis; Acute Kidney Injury; Acute Lung Injury

Condition Hierarchy (Ancestors)

Nephritis, Interstitial; Nephritis; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Pyelitis; Male Urogenital Diseases; Renal Insufficiency; Lung Injury; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Maxime Dr COUTROT, MD

  Hopital saint Louis-APHP

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 9, 2024
• First Posted: March 7, 2024
• Study Start: May 13, 2024
• Primary Completion: November 18, 2025
• Study Completion: November 18, 2025
• Last Updated: February 20, 2026

Record last verified: 2026-02

Locations

FR (1)