Autonomic and Metabolic Response to Cardiac Rehabilitation After Acute MI

NCT06298513 | Completed

• 1 other identifier: 09C338
• Study Type: observational
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

Ischemic heart disease remains the leading cause of death in the western world. The beneficial effects of cardiac rehabilitation on the evolution of ischemic heart disease are known, but the effects of rehabilitation on the metabolic processes of the patients are so far poorly understood. Metabolomics is the qualitative/quantitative analysis of the body's metabolic responses to pathophysiological stimuli or genetic alterations. Metabolic changes caused by physical activity have been demonstrated in obese and diabetic patients and in athletes. Aim of the study is to evaluate whether cardiac rehabilitation after a first myocardial infarction induces changes in the metabolic state of patients, and whether these changes may be related with changes in the usual risk factors (i.e. glyco-lipidic profile, natriuretic peptides, homocysteine).

Conditions

Acute Myocardial Infarction: Rehabilitation Phase

Keywords

myocardial infarction; cardiac rehabilitation; metabolomic; autonomic nervous ststem

Outcome Measures

Primary Outcomes (3)

• Changes in purine after rehabilitation

  The concentration of purine will be calculated after rehabilitation, and compared to its baseline concentration by a paired T test analysis.

  Baseline and after 6 weeks of rehabilitation

• Changes in histidine after rehabilitation

  The concentration of purine will be calculated after rehabilitation, and compared to its baseline concentration by a paired T test analysis

  Baseline and after 6 weeks of rehabilitation

• Changes in galactose after rehabilitation

  The concentration of galactose will be calculated after rehabilitation, and compared to its baseline concentration by a paired T test analysis.

  Baseline and after 6 weeks of rehabilitation

Study Arms (1)

Patient after first acute myocardial infarction

Other: Cardiac rehabilitation

Interventions

Cardiac rehabilitation OTHER

Six weeks of cardiac rehabilitation with physical training

Patient after first acute myocardial infarction

Eligibility Criteria

• Age: 25 Years - 75 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All consecutive patients meeting the eligibility criteria will be proposed to participate in the study

You may qualify if:

• recent first acute myocardial infarction

You may not qualify if:

• severe diabetes

Sponsors & Collaborators

• Istituto Auxologico Italiano: lead

Study Sites (1)

Istituto Auxologico Italiano

Milan, 20149, Italy

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

frozen plasma

MeSH Terms

Conditions

Myocardial Infarction

Interventions

Cardiac Rehabilitation

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Intervention Hierarchy (Ancestors)

Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Health Services; Health Care Facilities Workforce and Services

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 1, 2024
• First Posted: March 7, 2024
• Study Start: May 2, 2023
• Primary Completion: June 12, 2024
• Study Completion: January 13, 2025
• Last Updated: August 21, 2025

Record last verified: 2025-08

Locations

IT (1)