Perioperative Treatment of Resectable Intrahepatic Cholangiocarcinoma With the Combination of Adebrelimab and Apatinib and HAIC

NCT06296563 | Recruiting Phase 2

• 1 other identifier: SHR1316-ICC-SD-001
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to explore the efficacy and safety of combined infusion chemotherapy with Adebrelimab and Apatinib in the perioperative treatment of resectable intrahepatic cholangiocarcinoma patients. The main question it aims to answer are: How to improve the survival of patients with intrahepatic cholangiocarcinoma and prolong the recurrence time after surgery. Participants will receive receive neoadjuvant therapy with Adebrelimab combined with apatinib and FOLFOX-HAIC for 2 cycles (1 treatment cycle every 21 days, apatinib only used for the first cycle), and surgery was performed 14-28 days after the end of treatment. After 28 days of surgery, patients will continue to receive adjuvant treatment with Adebrelimab combined with apatinib for a maximum of one year.

Conditions

Intrahepatic Cholangiocarcinoma

Outcome Measures

Primary Outcomes (1)

• Pathologic complete response (pCR)

  The proportion of subjects whose postoperative pathological examination did not detect residual cancer cells.

  Up to one year

Secondary Outcomes (4)

• Objective response rate (ORR)

  Up to one year

• Event free survival (EFS)

  Up to two years

• Overall Survival (OS)

  Up to two years

• Disease Control Rate (DCR)

  Up to one year

Study Arms (1)

HAIC+Adebrelimab+apatinib

EXPERIMENTAL

Neoadjuvant therapy with Adebrelimab combined with apatinib and FOLFOX-HAIC for 2 cycles (1 treatment cycle every 21 days, apatinib only used for the first cycle), and surgery was performed 14-28 days after the end of treatment. After 28 days of surgery, patients will continue to receive adjuvant treatment with Adebrelimab combined with apatinib.

Procedure: HAIC; Drug: Adebrelimab; Drug: Apatinib

Interventions

HAIC PROCEDURE

FOLFOX-hepatic artery infusion for 2 times.

HAIC+Adebrelimab+apatinib

Adebrelimab DRUG

Adebrelimab 1200mg, ivgtt, d1, q3w,up to one year of use at most.

HAIC+Adebrelimab+apatinib

Apatinib DRUG

Apatinib 250mg, po, qd,q3w,up to one year of use at most.

HAIC+Adebrelimab+apatinib

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \. Pathological diagnosis as malignant tumor of Intrahepatic Cholangiocarcinoma;
• \. According to the UICC/AJCC TNM staging system (8th edition, 2017), resectable subjects were classified as Ib-IIIb stages;
• \. aged ≥ 18 years at the time of signing the Informed consent form (ICF);
• \. Expected survival time\>3 months;
• \. Both men and women are eligible;
• \. The patient's Eastern Oncology Collaborative Group (ECOG) physical condition score is 0 or 1;
• \. No serious complications, such as hypertension, coronary heart disease, or history of mental illness, and no history of severe allergies; Non pregnancy and non lactation period;
• \. The organ and blood system functions of the subjects meet the following requirements:
• Absolute neutrophil count (ANC) ≥ 1.5 × 10 \^ 9/L;
• Platelet count ≥ 75 × 10 \^ 9/L;
• Hemoglobin ≥ 90 g/L;
• Serum total bilirubin ≤ 1.5 x upper limit of normal (ULN);
• Aspartate aminotransferase (AST) and alanine aminotransferase ≤ 2.5 x ULN;
• Albumin ≥ 3g/dL
• Creatinine ≤ 1.5 x ULN

You may not qualify if:

• \. Patients who received PD-1, PD-L1, PD-L2, or CTLA-4 inhibitors before enrollment, or patients who directly received another stimulating or co inhibitory T cell receptor (such as CTLA-4, CD137);
• \. Use any other investigational drugs within 4 weeks prior to enrollment;
• \. Any history of active autoimmune diseases or autoimmune diseases (such as interstitial pneumonia, uveitis, enteritis, hepatitis, pituitary inflammation, vasculitis, myocarditis, nephritis, hyperthyroidism, hypothyroidism after hormone replacement therapy); Children with asthma who have completely improved in adulthood and do not require any intervention can be included, but patients who require intervention with bronchodilators cannot be included;
• \. Congenital or acquired immunodeficiency, such as infection with human immunodeficiency virus (HIV), active hepatitis B (HBV DNA 500IU/ml), hepatitis C (hepatitis C antibody positive, HCV-RNA above the detection limit of the analysis method), or co infection with hepatitis B and hepatitis C;
• \. Serious infection (such as intravenous infusion of antibiotics, antifungal or antiviral drugs) occurred within 4 weeks before the first administration, or unexplained fever\>38.5 ° C occurred during screening/before the first administration;
• \. History of allogeneic organ transplantation or allogeneic hematopoietic stem cell transplantation;
• \. Suffering from uncontrollable mental illness;
• \. The simultaneous occurrence of serious and/or uncontrollable diseases may affect the participation of the study, such as unstable angina pectoris, myocardial infarction within 6 months, unstable symptomatic arrhythmia, symptomatic congestive heart failure, poorly controlled diabetes, serious activities, uncontrollable infection after insufficient biliary drainage (such as tumor blocking the bile duct);
• \. Pregnancy (positive pregnancy test) or lactation period;
• \. Other cancers that have occurred in the past (within the past 5 years) or simultaneously, excluding non melanoma skin cancer and in situ cancer;
• \. History of allergy or hypersensitivity to any investigational drug;
• \. Currently abusing alcohol or illegal drugs;
• \. Unable or unwilling to sign informed consent form.

Sponsors & Collaborators

• Lei ZHAO: lead

Study Sites (1)

Shandong Cancer Hospital and Institute

Jinan, Shandong, 250117, China

RECRUITING

MeSH Terms

Conditions

Cholangiocarcinoma

Interventions

apatinib

Condition Hierarchy (Ancestors)

Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Director

Study Record Dates

• First Submitted: February 28, 2024
• First Posted: March 6, 2024
• Study Start: March 1, 2024
• Primary Completion (Estimated): March 1, 2027
• Study Completion (Estimated): March 1, 2029
• Last Updated: April 17, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)