Ibuprofen Inhibits Human Sweet Taste

NCT06291337 | Completed

• 2 other identifiers: Pro201900148310-204Mc
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

The sweet taste receptor, TAS1R2-TAS1R3, is expressed both orally, where it signals sweet taste, and extraorally in the intestine and pancreas, where it may affect glucose absorption and metabolism. Recently, ibuprofen and naproxen have been identified to inhibit human T1R3 when heterologously expressed in cells. In the present study, the initial objective was to determine if ibuprofen and naproxen inhibit interactions of sugars with human sweet taste receptor under normal, physiological conditions. Ten healthy participants were asked to rate sweetness intensity for a range of sweet stimuli (sucrose, fructose, sucralose) after a prerinse of ibuprofen, naproxen or water. Both ibuprofen and naproxen inhibited sweet taste intensity in a dose-dependent manner. In association studies, ibuprofen use has been linked to preserved metabolic function, as its use is correlated with lower rates of Alzheimer's disease, diabetes and colon cancer. Here the investigators present a potential novel pathway for systemic ibuprofen to impact these metabolic diseases.

Conditions

Treatment of Sweet Taste Receptors Without or With an Oral Rinse of Ibuprofen Solution in Healthy Participants; Treatment of Sweet Taste Receptors Without or With an Oral Rinse of Naproxen Solution in Healthy Participants

Outcome Measures

Primary Outcomes (2)

• Sweet taste ratings

  The impact of oral rinses with NSAIDS on sweet taste ratings of sugars on a labeled magnitude scale was assessed. The numeric outcome is the value of sweetness intensity provided by the participant from the labeled magnitude scale with each sweetener oral rinse.

  6 months

• Sugar detection thresholds

  The impact of oral rinses with NSAIDS on detection thresholds for sugars was assessed. The detection threshold is the lowest concentration of the sweetener solution that can be distinguished from water. The numeric outcome is the concentration of sweetener solution that can be distinguished from water.

  6 months

Study Arms (2)

Treatment of sweet taste receptors with Ibuprofen oral rinse

EXPERIMENTAL

Participants were tested for sweetness perception without and with an oral rinse of ibuprofen.

Drug: Inhibition of Sweet Taste by Ibuprofen Oral Rinses

Treatment of sweet taste receptors with naproxen oral rinse

EXPERIMENTAL

Participants were tested for sweetness perception without and with an oral rinse of naproxen.

Drug: Inhibition of Sweet Taste by Naproxen Oral Rinses

Interventions

Inhibition of Sweet Taste by Ibuprofen Oral Rinses DRUG

Participants rinse the mouth with ibuprofen and the impact on perceived sweet taste elicited by sugar solutions in the mouth was assessed

Treatment of sweet taste receptors with Ibuprofen oral rinse

Inhibition of Sweet Taste by Naproxen Oral Rinses DRUG

Participants rinse the mouth with naproxen and the impact on perceived sweet taste elicited by sugar solutions in the mouth was assessed

Treatment of sweet taste receptors with naproxen oral rinse

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Participant must be able to taste sugars as sweet
• Participant must be able to make ratings on a scale and follow instructions

You may not qualify if:

• Participant must not be on any medications that would preclude exposure to NSAIDS
• Participant must not be on any medications that are know to alter taste perception

Sponsors & Collaborators

• Rutgers, The State University of New Jersey: lead
• Monell Chemical Senses Center: collaborator

Study Sites (1)

Food Science and Nutritional Sciences

New Brunswick, New Jersey, 08901, United States

Location

Study Officials

• Paul A Breslin, Ph.D.

  Rutgers University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: We are testing individual sin a within subject control for their sweet taste ratings of sugars without and with oral rinses of ibuprofen and naproxen.

Study Record Dates

• First Submitted: February 15, 2024
• First Posted: March 4, 2024
• Study Start: June 1, 2020
• Primary Completion: September 1, 2023
• Study Completion: September 30, 2023
• Last Updated: March 4, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: Immediately following publication and ending 7 years following article publication.
• Access Criteria: Researchers who provide a methodologically sound proposal. Proposals should be directed to breslin@monell.org to request data to achieve aims of the proposal. Data are available for 7 years at a third party website:

Locations

US (1)