Factors of Control Hypertension or Type 2 Diabetes on the Severity of Stroke and Survival Rates Within 1 Year in Trat

NCT06288269 | Completed DMC

• 1 other identifier: PhrapokklaoHospital
• Study Type: observational
• Target: 291
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study was to study factors for controlling hypertension or type 2 diabetes before stroke diagnosis on the severity level when a stroke occurs, NIHSS, and survival rate after having a stroke in 1 year in Trat Province The research hypothesis was patients with hypertension or type 2 diabetes who are well-controlled Will have a lower NIHSS score than the group whose disease is not well-controlled. and patients with hypertension or type 2 diabetes that is well controlled There will be a higher survival rate for patients diagnosed with cerebrovascular disease within 1 year than those whose disease cannot be controlled.

Conditions

Stroke; Hypertension; Type2diabetes

Keywords

National Institute of Health Stroke Scale

Outcome Measures

Primary Outcomes (2)

• Stroke severity was assessed using the National Institute of Health Stroke Scale (Clinical Mild NIHSS = 0-4 and Clinical Moderate to severe NIHSS = 5-42)

  Patients with new stroke case with different diseases control will have different severity of stroke.

  Results of controlling diabetes and hypertension in the 1-3 year period before having a stroke.

• 1 year survival death

  Patients with new stroke case with different diseases control will have different death rate in 1 year

  1 year after stroke attack

Study Arms (2)

Control of Hypertension or/and Type 2 Diabetic

Control disease of HT Control disease of DM2 Control disease of HT plus DM2

Other: Severity of Stroke and 1 year survival

Uncontrol of Hypertension or/and Type 2 Diabetic

Uncontrol disease of HT Uncontrol disease of DM2 Uncontrol disease of HT plus DM2

Other: Severity of Stroke and 1 year survival

Interventions

Severity of Stroke and 1 year survival OTHER

Evaluated from NIHSS and clinical outcome 1 year survival death

Control of Hypertension or/and Type 2 Diabetic; Uncontrol of Hypertension or/and Type 2 Diabetic

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

A sample group of people who have had a stroke in fiscal year 2022 of people living in Trat Province. From the medical records center of Trat Hospital that received a diagnosis of stroke and were admitted to the hospital, a total of 729 cases were taken into the study process with criteria for selecting research participants (Inclusion criteria) and criteria. Exclusion criteria resulted in 291 patients who met the aforementioned criteria. There were 244 patients with hypertension as a comorbidity, 129 patients with type 2 diabetes as a comorbidity, and 100 patients with hypertension and type 2 diabetes as a comorbidity.

You may qualify if:

• Patients who have chronic hypertension or type 2 diabetes with a history of illness of at least 1 year before the stroke.
• Patients had a new stroke for the first time in his life, including an ischemic stroke. hemorrhagic stroke and hemorrhage in the brain
• The patient was confirmed by CT scan
• Thai nationality.

You may not qualify if:

• Patients diagnosed with cerebrovascular disease who have a previous history of ischemic or hemorrhagic stroke.
• Patients diagnosed with transient ischemic attack
• Patients who have a history of chronic disease that are at high risk of having a stroke, such as being a pregnant patient, still taking birth control pills.
• There are certain genetic diseases, such as antiphospholipid syndrome
• Patients had previous history of brain aneurysm, extracranial arterial dissection, atrial fibrillation, drug addict use, etc.

Sponsors & Collaborators

• Phrapokklao Hospital,Thailand: lead

Study Sites (1)

Trat Provincial Public Health Office

Trat, 23000, Thailand

Location

Related Publications (12)

• Division of Noncommunicable Diseases DoDC, Ministry of Public Health,. Report on the situation of NCDs, diabetes, and high blood pressure. and related risk factors 2019. Akson Graphic and design Printing and Publishing 2019. 8-9 p.

  BACKGROUND

• Kogan E, Twyman K, Heap J, Milentijevic D, Lin JH, Alberts M. Assessing stroke severity using electronic health record data: a machine learning approach. BMC Med Inform Decis Mak. 2020 Jan 8;20(1):8. doi: 10.1186/s12911-019-1010-x.

  PMID: 31914991 BACKGROUND

• Tziomalos K, Spanou M, Bouziana SD, Papadopoulou M, Giampatzis V, Kostaki S, Dourliou V, Tsopozidi M, Savopoulos C, Hatzitolios AI. Type 2 diabetes is associated with a worse functional outcome of ischemic stroke. World J Diabetes. 2014 Dec 15;5(6):939-44. doi: 10.4239/wjd.v5.i6.939.

  PMID: 25512800 BACKGROUND

• Alawneh KZ, Qawasmeh MA, Raffee LA, Al-Mistarehi AH. Ischemic stroke demographics, clinical features and scales and their correlations: an exploratory study from Jordan. Future Sci OA. 2022 Aug 5;8(7):FSO809. doi: 10.2144/fsoa-2022-0017. eCollection 2022 Aug.

  PMID: 36248068 BACKGROUND

• Zhang X, Liu Y, Zhang F, Li J, Tong N. Legacy Effect of Intensive Blood Glucose Control on Cardiovascular Outcomes in Patients With Type 2 Diabetes and Very High Risk or Secondary Prevention of Cardiovascular Disease: A Meta-analysis of Randomized Controlled Trials. Clin Ther. 2018 May;40(5):776-788.e3. doi: 10.1016/j.clinthera.2018.03.015. Epub 2018 Apr 12.

  PMID: 29656857 BACKGROUND

• Vemmos KN, Tsivgoulis G, Spengos K, Zakopoulos N, Synetos A, Manios E, Konstantopoulou P, Mavrikakis M. U-shaped relationship between mortality and admission blood pressure in patients with acute stroke. J Intern Med. 2004 Feb;255(2):257-65. doi: 10.1046/j.1365-2796.2003.01291.x.

  PMID: 14746563 BACKGROUND

• Ntaios G, Egli M, Faouzi M, Michel P. J-shaped association between serum glucose and functional outcome in acute ischemic stroke. Stroke. 2010 Oct;41(10):2366-70. doi: 10.1161/STROKEAHA.110.592170. Epub 2010 Aug 19.

  PMID: 20724712 BACKGROUND

• Hu G, Sarti C, Jousilahti P, Peltonen M, Qiao Q, Antikainen R, Tuomilehto J. The impact of history of hypertension and type 2 diabetes at baseline on the incidence of stroke and stroke mortality. Stroke. 2005 Dec;36(12):2538-43. doi: 10.1161/01.STR.0000190894.30964.75. Epub 2005 Nov 10.

  PMID: 16282538 BACKGROUND

• Chang WW, Fei SZ, Pan N, Yao YS, Jin YL. Incident Stroke and Its Influencing Factors in Patients With Type 2 Diabetes Mellitus and/or Hypertension: A Prospective Cohort Study. Front Cardiovasc Med. 2022 Feb 9;9:770025. doi: 10.3389/fcvm.2022.770025. eCollection 2022.

  PMID: 35224030 BACKGROUND

• Murphy SJ, Werring DJ. Stroke: causes and clinical features. Medicine (Abingdon). 2020 Sep;48(9):561-566. doi: 10.1016/j.mpmed.2020.06.002. Epub 2020 Aug 6.

  PMID: 32837228 BACKGROUND

• American Diabetes Association. Standards of Medical Care in Diabetes-2022 Abridged for Primary Care Providers. Clin Diabetes. 2022 Jan;40(1):10-38. doi: 10.2337/cd22-as01. No abstract available.

  PMID: 35221470 BACKGROUND

• Kandil H, Soliman A, Alghamdi NS, Jennings JR, El-Baz A. Using Mean Arterial Pressure in Hypertension Diagnosis versus Using Either Systolic or Diastolic Blood Pressure Measurements. Biomedicines. 2023 Mar 10;11(3):849. doi: 10.3390/biomedicines11030849.

  PMID: 36979828 BACKGROUND

Related Links

• World Stroke Organization. WSO Global Stroke Fact Sheet 2022 \[Internet\]. 2022.

MeSH Terms

Conditions

Stroke; Hypertension

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Panuwat Soponlertpong

  Trat Provincial Public Health Office

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Deputy Public Health Doctor of Trat Province

Study Record Dates

• First Submitted: February 2, 2024
• First Posted: March 1, 2024
• Study Start: November 1, 2023
• Primary Completion: December 30, 2023
• Study Completion: January 15, 2024
• Last Updated: March 7, 2024

Record last verified: 2024-03

Locations

TH (1)