Alveolar-capillary Reserve After Exercise in Chronic Obstructive Pulmonary Disease (COPD) (COP-DTPA)

NCT06287476 | Completed

• 1 other identifier: H-23043870
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

It is unknown whether individuals with COPD exhibit abnormal alveolar-capillary breaching during exercise, and whether this contributes to exertional dyspnoea. The aim of this study is to investigate whether individuals with COPD exhibit an abnormal increase in alveolar-capillary breaching during exertion, as indicated by an increase alveolar-capillary permeability with a concomitantly exacerbated increase in lung tissue mass.

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

COPD; Alveolar-capillary membrane integrity; Lung tissue mass; Cardiac Output; DLCO/DLNO

Outcome Measures

Primary Outcomes (1)

• Rest-to-exercise pulmonary DTPA clearance change after exercise in COPD vs. controls

  The physiological change from rest to exercise in DTPA clearance

  Measured at study day 2

Secondary Outcomes (3)

• Pulmonary DTPA clearance at rest in COPD vs. controls

  Measured at study day 2

• Pulmonary DTPA clearance after exercise in COPD vs. controls

  Measured at study day 2

• Rest-to-exercise change in lung tissue mass in COPD vs. controls

  Measured at study day 2

Other Outcomes (13)

• Lung tissue mass at rest in COPD vs. controls

  Measured at study day 2

• Lung tissue mass after exercise in COPD vs. controls

  Measured at study day 2

• Rest-to-exercise pulmonary DTPA clearance and lung tissue mass change according to GOLD

  Measured at study day 2

Study Arms (2)

Control Group

EXPERIMENTAL

This arm consist of only healthy participants (age (+/- 3 years) and sex matched to the COPD group), which will undergo three study visits

Other: Acute exercise bout on visit 2 and 3

COPD group

EXPERIMENTAL

This arm consist of only COPD patients, which will undergo three study visits

Other: Acute exercise bout on visit 2 and 3

Interventions

Acute exercise bout on visit 2 and 3 OTHER

1\) a 5-minute warm-up, 2) 4 minutes at 60% of the maximal workload (determined on Study Day 1), 3) 2 minutes active break at 15 watt, 4) 4 minutes at maximal workload.

COPD group; Control Group

Eligibility Criteria

• Age: 45 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Men and women
• years old
• COPD (GOLD stage I to III)
• Resting arterial oxygenation \> 90%
• Men and women
• years old
• Non-smokers
• Normal lung function
• Same sex, age (± 3 years) as the COPD group

You may not qualify if:

• Symptoms of ischemic heart disease
• Known heart failure
• Symptoms of illness, including fever, within 2 weeks prior to the study
• Pregnancy
• Known renal or liver diseaseActive smoking (within 3 weeks)
• Known chronic lung disease
• Symptoms of ischemic heart disease
• Known heart failure
• Symptoms of illness, including fever, within 2 weeks prior to the study
• Pregnancy
• Known renal or liver disease
• Active smoking (within 3 weeks)

Sponsors & Collaborators

• Rigshospitalet, Denmark: lead

Study Sites (1)

Center For Physical Activity Research, Rigshospitalet

Copenhagen, Denmark

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, DMSc, Associate Professor

Study Record Dates

• First Submitted: February 12, 2024
• First Posted: March 1, 2024
• Study Start: May 6, 2024
• Primary Completion: May 2, 2025
• Study Completion: May 2, 2025
• Last Updated: December 8, 2025

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

DK (1)