Complications of High Frequency Jet Ventilation

NCT06285994 | Completed

• 1 other identifier: SRB2024016
• Study Type: observational
• Target: 1,385
• Locations: 1 country
• Sites: 1

Brief Summary

High frequency jet ventilation (HFJV) has been introduced in 1967 as technique allowing ventilation with simultaneous access to the airway for bronchoscopy. Continuous improvement in the technique has led to a large use during interventional bronchoscopy, especially in large centers. However, complications occuring during the use of HFJV are poorly known. In this retrospective cohort study, the charts of all patients who had a bronchoscopy with the use of HFJV between 2019 and 2023 in our hospital will be analyzed. Primary outcome will the description of all complications during HFJV. Complications are defined as:

• Hypoxia: SpO2 \< 90% for 1 min
• Severe hypoxia: SpO2 \< 85% for 1 min
• Hemodynamic instability, defined as Arterial pressure \< 90/60
• Cardiac arrhythmia
• Laryngospasm or bronchospasm
• Barotrauma or volutrauma
• Need for ICU admission A model predicting the risk for developing any complication will be developped using 2 mathematical methods:
• a multivariate analysis
• a data mining approach For both approaches, the following variables will be included in the model:
• Age
• Gender
• Weight
• Height
• BMI
• Smoking
• Alcohol consumption
• Consumption of Other drugs
• ASA class
• Obstructive pulmonary disease
• Restrictive lung disease
• COPD status (1, 2, 3, 4)
• Interstitial lung disease
• Lung tumor
• Trachea location
• Carina location
• Bronchial location
• Pulmonary or tracheal stenosis
• Presence of stridor
• Severe stenosis (\< 6 mm)
• Baseline SpO2 (pre-intervention)
• Pre-intervention oxygen requirement Procedure
• Duration (min)
• Stent placement
• Dilation
• Laser treatment
• Length of hospital stay Lung function tests
• FEV1 (forced expiratory volume)
• VC (Vital Capacity)
• FEV1/VC (Tiffeneau ratio)
• CPT (total lung capacity)
• DLCO (carbon monoxide diffusion)

Conditions

High-Frequency Jet Ventilation; Bronchoscopy

Outcome Measures

Primary Outcomes (1)

• Occurence of complications

  The occurence (%) of complications of HFJV will be analyzed. Definition of complications is one or more of the following events: * Hypoxia: SpO2 \< 90% for 1 min (%) * Severe hypoxia: SpO2 \< 85% for 1 min (%) * Hemodynamic instability, defined as Arterial pressure \< 90/60 (%) * Cardiac arrhythmia (%) * Laryngospasm or bronchospasm (%) * Barotrauma or volutrauma (%) * Need for ICU admission (%) Complications will be reported as overall complications (%) defined as the occurence of one or more of the listed events. Frequency of single events will be reported separately (%). Descriptive statistics ( %, mean, standard deviation, median, interquartile range) will be used as appropriate.

  6 hours

Secondary Outcomes (1)

• Prediction model of complications

  6 hours

Study Arms (1)

HFJV

All patients who underwent bronchoscopy with the use of high frequency jet ventilation between January 1st 2019 and december 31st 2023.

Procedure: High frequency jet ventilation

Interventions

High frequency jet ventilation PROCEDURE

Use of high frequency jet ventilation during bronchoscopy

HFJV

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients who underwent a bronchoscopy with the use of high frequency jet ventilation

You may qualify if:

• All patients who underwent a bronchoscopy with the use of high frequency jet ventilation between January 1st, 2019 and December 31st, 2023 at Erasme University Hospital, Brussels

You may not qualify if:

• Incomplete medical chart
• Patient who expressed their opposition to the use of their medical data

Sponsors & Collaborators

• Erasme University Hospital: lead

Study Sites (1)

Hôpital Universitaire de Bruxelles - Hôpital erasme

Brussels, 1070, Belgium

Location

Related Publications (8)

• Aravena C, Mehta AC, Almeida FA, Lamb C, Maldonado F, Gildea TR. Innovation in rigid bronchoscopy-past, present, and future. J Thorac Dis. 2023 May 30;15(5):2836-2847. doi: 10.21037/jtd-22-779. Epub 2023 Apr 25.

  PMID: 37324083 BACKGROUND

• Putz L, Mayne A, Dincq AS. Jet Ventilation during Rigid Bronchoscopy in Adults: A Focused Review. Biomed Res Int. 2016;2016:4234861. doi: 10.1155/2016/4234861. Epub 2016 Oct 26.

  PMID: 27847813 BACKGROUND

• Poling HE, Wolfson B, Siker ES. A technique of ventilation during laryngoscopy and bronchoscopy. Br J Anaesth. 1975 Mar;47(3):382-4. doi: 10.1093/bja/47.3.382.

  PMID: 1138745 BACKGROUND

• Klain M, Smith RB. High frequency percutaneous transtracheal jet ventilation. Crit Care Med. 1977 Nov-Dec;5(6):280-7. doi: 10.1097/00003246-197711000-00007. No abstract available.

  PMID: 338247 BACKGROUND

• Hautmann H, Gamarra F, Henke M, Diehm S, Huber RM. High frequency jet ventilation in interventional fiberoptic bronchoscopy. Anesth Analg. 2000 Jun;90(6):1436-40. doi: 10.1097/00000539-200006000-00034.

  PMID: 10825336 BACKGROUND

• Ost DE, Ernst A, Grosu HB, Lei X, Diaz-Mendoza J, Slade M, Gildea TR, Machuzak M, Jimenez CA, Toth J, Kovitz KL, Ray C, Greenhill S, Casal RF, Almeida FA, Wahidi M, Eapen GA, Yarmus LB, Morice RC, Benzaquen S, Tremblay A, Simoff M; AQuIRE Bronchoscopy Registry. Complications Following Therapeutic Bronchoscopy for Malignant Central Airway Obstruction: Results of the AQuIRE Registry. Chest. 2015 Aug;148(2):450-471. doi: 10.1378/chest.14-1530.

  PMID: 25741903 BACKGROUND

• Goudra BG, Singh PM, Borle A, Farid N, Harris K. Anesthesia for Advanced Bronchoscopic Procedures: State-of-the-Art Review. Lung. 2015 Aug;193(4):453-65. doi: 10.1007/s00408-015-9733-7. Epub 2015 Apr 29.

  PMID: 25921014 BACKGROUND

• Fernandez-Bustamante A, Ibanez V, Alfaro JJ, de Miguel E, German MJ, Mayo A, Jimeno A, Perez-Cerda F, Escribano PM. High-frequency jet ventilation in interventional bronchoscopy: factors with predictive value on high-frequency jet ventilation complications. J Clin Anesth. 2006 Aug;18(5):349-56. doi: 10.1016/j.jclinane.2005.12.011.

  PMID: 16905080 BACKGROUND

MeSH Terms

Interventions

High-Frequency Jet Ventilation

Intervention Hierarchy (Ancestors)

High-Frequency Ventilation; Respiration, Artificial; Airway Management; Therapeutics; Respiratory Therapy

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 12, 2024
• First Posted: February 29, 2024
• Study Start: March 3, 2024
• Primary Completion: March 19, 2024
• Study Completion: February 1, 2025
• Last Updated: May 21, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)