Red Blood Cell Distributions (RDW, RDW-CW) and Lymphocyte Monocyte Ratios (LMR) for the Malignant Thyroid Nodules

NCT06283368 | Completed

• 1 other identifier: 2021/11-06
• Study Type: observational
• Target: 172
• Locations: 0 countries
• Sites: N/A

Brief Summary

Thyroid surgery is the most common type of surgery among endocrine surgeries. This surgery is performed for patients with suspected malignancy, patients diagnosed with malignancy, and toxic nodular goiter. In addition to vocal cord injury, which is the most important complication of thyroid surgery, hypocalcemia due to hypoparathyroidism and surgical wound complications (such as hematoma, and fistula) can also be observed, and malignancy surgery increases the risk of recurrent laryngeal nerve injury. Therefore, it is important to differentiate these groups using non-invasive methods before surgery. Tumor-related inflammation is activated as a result of bone marrow and inflammation induced by malignancies. Insufficiently controlled or uncontrolled inflammatory activity may be responsible for malignant transformation. Lymphocyte monocyte ratio and red blood cell distribution are parameters (RDW, RDW-CW) previously studied in terms of cancers. Our aim in this study is to reveal the RDW, RDW-CW, and LMR calculated from complete blood count parameters in the preoperative period, as an indicator of malignant inflammatory response, in a non-invasive and inexpensive way before surgery or biopsy is performed to distinguish nodular goiter and thyroid malignancy.

Conditions

Thyroid Neoplasms Benign; Thyroid Nodule; Thyroid Cancer; Thyroid Diseases

Outcome Measures

Primary Outcomes (2)

• Determining benign thyroid nodules

  Determining benign thyroid nodules noninvasively in the preoperative period with complete blood cell parameters

  2016-2021

• Determining malignant thyroid nodules

  Determining malignant thyroid nodules noninvasively in the preoperative period with complete blood cell parameters

  2016-2021

Study Arms (2)

Benign Thyroid Pathologies

Nodular Goiter Graves Diseases Tocsic Thyroid Nodular Disease

Procedure: Thyroidectomy, Bilaterally Total; Procedure: Thyroidectomy, Unilaterally Total; Procedure: Thyroidectomy, Complementary; Procedure: Thyroidectomy, Near Total

Thyroid Cancer Cases

Papillary Thyroid Carcinoma Medullary Thyroid Carcinoma Hurthle Cell Carcinoma Anaplastic Thyroid Carcinoma

Procedure: Thyroidectomy, Bilaterally Total; Procedure: Thyroidectomy, Unilaterally Total; Procedure: Thyroidectomy, Complementary; Procedure: Thyroidectomy, Near Total

Interventions

Thyroidectomy, Bilaterally Total PROCEDURE

Thyroidectomy, Bilaterally Total

Benign Thyroid Pathologies; Thyroid Cancer Cases

Thyroidectomy, Unilaterally Total PROCEDURE

Thyroidectomy, Unilaterally Total

Benign Thyroid Pathologies; Thyroid Cancer Cases

Thyroidectomy, Complementary PROCEDURE

Thyroidectomy, Complementary

Benign Thyroid Pathologies; Thyroid Cancer Cases

Thyroidectomy, Near Total PROCEDURE

Thyroidectomy, Near Total

Benign Thyroid Pathologies; Thyroid Cancer Cases

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who need thyroid surgery for the malignant and benign ethiologies

You may qualify if:

• Older than 18 age
• Thyroidectomy cases

You may not qualify if:

• Younger than 18 age
• Patients with other system malignancies
• Patients with missing data

Sponsors & Collaborators

• Kahramanmaras Sutcu Imam University: lead

Related Publications (4)

• Bozan MB, Yazar FM, Kale IT, Yuzbasioglu MF, Boran OF, Azak Bozan A. Delta Neutrophil Index and Neutrophil-to-Lymphocyte Ratio in the Differentiation of Thyroid Malignancy and Nodular Goiter. World J Surg. 2021 Feb;45(2):507-514. doi: 10.1007/s00268-020-05822-6. Epub 2020 Oct 16.

  PMID: 33067685 BACKGROUND

• Lee F, Yang PS, Chien MN, Lee JJ, Leung CH, Cheng SP. An Increased Neutrophil-to-Lymphocyte Ratio Predicts Incomplete Response to Therapy in Differentiated Thyroid Cancer. Int J Med Sci. 2018 Nov 23;15(14):1757-1763. doi: 10.7150/ijms.28498. eCollection 2018.

  PMID: 30588200 BACKGROUND

• Wen W, Wu P, Li J, Wang H, Sun J, Chen H. Predictive values of the selected inflammatory index in elderly patients with papillary thyroid cancer. J Transl Med. 2018 Sep 21;16(1):261. doi: 10.1186/s12967-018-1636-y.

  PMID: 30241494 BACKGROUND

• Yaylaci S, Tosun O, Sahin O, Genc AB, Aydin E, Demiral G, Karahalil F, Olt S, Ergenc H, Varim C. Lack of Variation in Inflammatory Hematological Parameters between Benign Nodular Goiter and Papillary Thyroid Cancer. Asian Pac J Cancer Prev. 2016;17(4):2321-3. doi: 10.7314/apjcp.2016.17.4.2321.

  PMID: 27221938 BACKGROUND

MeSH Terms

Conditions

Thyroid Nodule; Thyroid Neoplasms; Thyroid Diseases

Interventions

Thyroidectomy

Condition Hierarchy (Ancestors)

Endocrine Gland Neoplasms; Neoplasms by Site; Neoplasms; Head and Neck Neoplasms; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Endocrine Surgical Procedures; Surgical Procedures, Operative

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor, Associate

Study Record Dates

• First Submitted: February 21, 2024
• First Posted: February 28, 2024
• Study Start: January 1, 2016
• Primary Completion: January 1, 2021
• Study Completion: January 1, 2021
• Last Updated: March 1, 2024

Record last verified: 2024-02