Correlation Between Expression of Hormonal Receptors, Clinical Data, and Methylation Profile in Meningiomas (MethylRH-M)

NCT06278103 | Enrolling By Invitation

• 1 other identifier: 2023PI113
• Study Type: observational
• Target: 180
• Locations: 0 countries
• Sites: N/A

Brief Summary

This research aims to explore the relationship between hormonal receptor expression and the clinical and histopathological characteristics of meningiomas. The underlying hypothesis is that hormonal receptor expression, as well as the methylation profile of their gene promoters, are associated with specific aspects of meningiomas and patients' clinical outcomes. The main objective is to study the correlation between the immunohistochemical expression of hormonal receptors and clinicopathological data. The secondary objectif is to study the correlation between the methylation profile of hormonal receptor gene promoters and their immunohistochemical expression.

Conditions

Meningioma

Keywords

Meningioma; Hormonal receptors

Outcome Measures

Primary Outcomes (1)

• immunohistochemical expression of different hormonal receptors

  Evaluated on FFPE sections

  up to 24 years after surgery

Secondary Outcomes (1)

• methylation profile of the promoters of hormonal receptor genes

  up to 24 years after surgery

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients who underwent surgery for a meningioma at the University Hospital of Nancy between 2000 and 2022.

You may qualify if:

• Patients who underwent surgery for a meningioma at the University Hospital of Nancy between 2000 and 2022.

You may not qualify if:

• Patients who did not express their consent to participate in the study.
• Patients with grade 2 or 3 meningiomas whose samples are no longer available or in insufficient quantity to perform an immunohistochemical study.
• Patients with grade 1 meningiomas not selected by randomization.
• Patients withdrawing their consent.

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

Biospecimen

Retention: SAMPLES WITH DNA

FFPE blocks. Frozen tumoral tissue.

MeSH Terms

Conditions

Meningioma

Condition Hierarchy (Ancestors)

Neoplasms, Nerve Tissue; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Vascular Tissue; Meningeal Neoplasms; Central Nervous System Neoplasms; Nervous System Neoplasms; Neoplasms by Site; Nervous System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 24 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: February 19, 2024
• First Posted: February 26, 2024
• Study Start: January 1, 2000
• Primary Completion: July 1, 2024
• Study Completion: September 1, 2024
• Last Updated: February 26, 2024

Record last verified: 2024-02