NCT06275568

Brief Summary

The purpose of the study is to assess if the Fresh Connect food prescription (Fresh Connect Food Rx) program that provides consistent access to healthy fresh produce through purchases at the grocery store plus nutrition education impacts gestational weight gain, other pregnancy and birth outcomes, and food and nutrition security in low-income, ethnically diverse, at-risk women residing in Houston, Texas. Enrollment of participants will begin in pregnancy at the time of the first prenatal visit (as long as the first visit occurs before the end of the first trimester); each participant will be followed until 60 days post-partum (up to 11 months follow-up per participant).

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
620

participants targeted

Target at P75+ for not_applicable

Timeline
16mo left

Started Jul 2025

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress45%
Jul 2025Dec 2027

First Submitted

Initial submission to the registry

November 3, 2023

Completed
4 months until next milestone

First Posted

Study publicly available on registry

February 23, 2024

Completed
1.4 years until next milestone

Study Start

First participant enrolled

July 3, 2025

Completed
1.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2027

Expected
10 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2027

Last Updated

July 13, 2026

Status Verified

September 1, 2025

Enrollment Period

1.6 years

First QC Date

November 3, 2023

Last Update Submit

July 9, 2026

Conditions

Outcome Measures

Primary Outcomes (6)

  • Absolute gestational weight gain (GWG) in pounds

    From the start of the first trimester of pregnancy to the end of the first trimester of pregnancy (3 months)

  • Absolute gestational weight gain (GWG) in pounds

    From the start of the second trimester of pregnancy to the end of the second trimester of pregnancy (3 months)

  • Absolute gestational weight gain (GWG) in pounds

    From the start of the third trimester of pregnancy to the end of the third trimester of pregnancy (3 months)

  • Excess gestational weight gain (EGWG) in pounds

    From the start of the first trimester of pregnancy to the end of the first trimester of pregnancy (3 months)

  • Excess gestational weight gain (EGWG) in pounds

    From the start of the second trimester of pregnancy to the end of the second trimester of pregnancy (3 months)

  • Excess gestational weight gain (EGWG) in pounds

    From the start of the third trimester of pregnancy to the end of the third trimester of pregnancy (3 months)

Secondary Outcomes (4)

  • Number of participants diagnosed with pregnancy-induced hypertension

    From the time of enrollment until the time of birth (up to 9 months)

  • Number of participants diagnosed with gestational diabetes

    From the time of enrollment until the time of birth (up to 9 months)

  • Number of participants with pre-term birth (<37 weeks)

    at the time of birth

  • Infant birth weight

    at the time of birth

Study Arms (2)

Usual care Fresh Connect cardholder engagement

ACTIVE COMPARATOR
Behavioral: Usual Care Fresh Connect cardholder engagement

Usual care Fresh Connect cardholder engagement plus Enhanced engagement communication

EXPERIMENTAL
Behavioral: Usual Care Fresh Connect cardholder engagementBehavioral: Enhanced engagement communication

Interventions

Fresh Connect, a Food as Medicine product of the non-profit organization About Fresh, Inc., consists of a pre paid, programmable debit card, a cloud-based cardholder success platform, and an analytic engine designed to illuminate the healthcare value of improved food access and nutritional security. This arm receives: * About Fresh Food Rx debit card ($100 per month from enrollment until 2 months post-partum) * Texts for all cardholders per month (1-2 outbound texts) * Welcome call from About Fresh cardholder engagement team * 1 text - notification that Fresh Connect funds have been reloaded * As-needed program updates (e.g. new retailers), inactivity outreach * Additional texts that would be ad hocs: texts with food experiences (cooking videos), produce how-tos, and fun engagement; and satisfaction surveys - e.g. feedback on the Fresh Connect program, feedback on retailers, satisfaction with cardholder success, etc.

Usual care Fresh Connect cardholder engagementUsual care Fresh Connect cardholder engagement plus Enhanced engagement communication

Enhanced engagement involves additional outbound texts per month and additional ad hoc bi-monthly or quarterly texts, as well as tailored reminder text to use funds before the end of the month.

Usual care Fresh Connect cardholder engagement plus Enhanced engagement communication

Eligibility Criteria

Age18 Years+
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Less than or equal to 20 weeks medically confirmed viable pregnancy
  • high-risk pregnant mothers receiving care at Community Health Choice managed care organizations in Houston, Texas (High risk may include overweight/obese pre-pregnancy or at first trimester (self-report or measured BMI\>30.0), and/or prior history of diabetes or gestational diabetes, and/or prior history of hypertension or pregnancy-induced hypertension)

You may not qualify if:

  • Does not Speak English or Spanish

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

The University of Texas Health Science Center at Houston

Houston, Texas, 77030, United States

RECRUITING

Related Links

Study Officials

  • Shreela Sharma, PhD

    The University of Texas Health Science Center, Houston

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

November 3, 2023

First Posted

February 23, 2024

Study Start

July 3, 2025

Primary Completion (Estimated)

February 1, 2027

Study Completion (Estimated)

December 1, 2027

Last Updated

July 13, 2026

Record last verified: 2025-09

Data Sharing

IPD Sharing
Will share

At the end of the project, de-identified data at individual level will be uploaded to the American Heart Association (AHA) Precision-Medicine Platform.

Shared Documents
STUDY PROTOCOL, SAP, ICF
Time Frame
June 2025
Access Criteria
Will be determined by AHA.

Locations