NCT06275412

Brief Summary

The purpose of this study is to conduct a multicenter, randomized effectiveness trial of The 3Ms 2.0 compared to an educational control condition for improving adolescent glycemic control and diabetes-related family relationships and reducing primary caregiver diabetes-related distress among Black adolescents with type 1 diabetes (T1D) and their primary caregivers. The proposed study would develop and test The 3Ms 2.0 adapted intervention when delivered using a mobile health approach (accessed via parents' cell phone). The intervention will also include new family intervention content (videoclips and text messages).

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
216

participants targeted

Target at P75+ for not_applicable

Timeline
24mo left

Started Sep 2024

Longer than P75 for not_applicable

Geographic Reach
1 country

4 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress45%
Sep 2024Apr 2028

First Submitted

Initial submission to the registry

February 8, 2024

Completed
15 days until next milestone

First Posted

Study publicly available on registry

February 23, 2024

Completed
7 months until next milestone

Study Start

First participant enrolled

September 16, 2024

Completed
3.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 30, 2028

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 30, 2028

Last Updated

July 15, 2025

Status Verified

July 1, 2025

Enrollment Period

3.6 years

First QC Date

February 8, 2024

Last Update Submit

July 14, 2025

Conditions

Keywords

Type 1 Diabetesmobile healthFamily-based intervention

Outcome Measures

Primary Outcomes (1)

  • Glycemic Control

    Hemoglobin A1c (HbA1c)

    Baseline, 3 months, 6 months, and 12 months

Secondary Outcomes (4)

  • Caregiver Diabetes Distress

    Baseline, 3 months, 6 months, and 12 months

  • Diabetes-Specific Family Conflict

    Baseline, 3 months, 6 months, and 12 months

  • Diabetes-Specific Parental Monitoring

    Baseline, 3 months, 6 months and 12 months

  • Diabetes-Specific Family Support

    Baseline, 3 months, 6 months and 12 months

Other Outcomes (2)

  • Illness Management

    Baseline, 3 months, 6 months, and 12 months

  • Intervention Satisfaction

    6 months

Study Arms (2)

Educational Attention Control (EAC) + Standard Medical Care

ACTIVE COMPARATOR
Behavioral: Educational Attention Control (EAC)

The 3Ms 2.0 Intervention + Standard Medical Care

EXPERIMENTAL
Behavioral: The 3Ms 2.0 Intervention

Interventions

The 3Ms is a culturally tailored, mHealth intervention for primary caregivers of Black adolescents with T1D focused on promoting daily parental monitoring of adolescent diabetes care and delivered via an Internet platform, Computer Intervention Authoring System (CIAS). The intervention content is based on the Information-Motivation-Behavioral Skills (IMB) model. Caregivers randomized to The 3Ms receive 3 sessions. The caregiver is guided through each session by an interactive and emotive three-dimensional narrator that reads and speaks aloud. Additional intervention content includes brief videoclips to provide skills demonstrations of supportive parenting practices related to diabetes care and text message reminders. Each session is no more than 20 minutes in length. The intervention is delivered over a three-month window, with the two follow-up sessions available to be accessed by the caregiver at one-month intervals after completion of the initial session.

The 3Ms 2.0 Intervention + Standard Medical Care

The EAC intervention consists of three sessions delivered in an mHealth format via the CIAS internet platform over three months, with access for a maximum of six months. EAC provides structured information on topics of interest to caregivers of adolescents with T1D such as travelling with diabetes, or emergency preparedness for persons with diabetes. All participants receive their standard medical care.

Educational Attention Control (EAC) + Standard Medical Care

Eligibility Criteria

Age10 Years - 14 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • Age: 10 years, 0 months - 14 years, 11 months
  • Diagnosed with Type 1 diabetes
  • Diagnosed for at least 6 months
  • Black
  • Primary caregiver willing to participate
  • Residence within 30 miles of a recruitment site
  • Caregiver ownership of an Internet-enabled device (cell phone, laptop or desktop computer, tablet, etc)

You may not qualify if:

  • Mental health conditions that might compromise data integrity (e.g., developmental delay, schizophrenia, psychosis, current suicidality, homicidality)
  • Co-morbid medical condition resulting in atypical diabetes management (e.g., cystic fibrosis)
  • Inability to speak or read English
  • Child is in out-of-home placement

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (4)

Children's National Hospital

Washington D.C., District of Columbia, 20010, United States

RECRUITING

Wayne Pediatrics

Detroit, Michigan, 48201, United States

RECRUITING

LeBonheur Children's Hospital

Memphis, Tennessee, 38103, United States

RECRUITING

University of Tennessee Health Science Center-Memphis

Memphis, Tennessee, 38163, United States

RECRUITING

MeSH Terms

Conditions

Diabetes Mellitus, Type 1

Condition Hierarchy (Ancestors)

Diabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System DiseasesAutoimmune DiseasesImmune System Diseases

Study Officials

  • Deborah A Ellis, Ph.D.

    Wayne State University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Deborah A Ellis, Ph.D.

CONTACT

Jillian T Sjostrom, B.S.

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
CARE PROVIDER
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Deborah Ellis, Ph.D., Professor of Family Medicine and Public Health Sciences Wayne State University School of Medicine

Study Record Dates

First Submitted

February 8, 2024

First Posted

February 23, 2024

Study Start

September 16, 2024

Primary Completion (Estimated)

April 30, 2028

Study Completion (Estimated)

April 30, 2028

Last Updated

July 15, 2025

Record last verified: 2025-07

Data Sharing

IPD Sharing
Will share

Identifiers will be removed from the data prior to any release of the dataset. The final data set will include data obtained from medical records, data obtained directly from participants on diabetes health status, behavioral data, and intervention data. Participants in the trial will be recruited through two children's hospitals. Even though the final dataset will not contain identifiers, given the relatively small sample size and focus on Black youth, there remains the possibility of deductive identification of subjects with unusual characteristics (i.e. high number hospital admissions).

Shared Documents
STUDY PROTOCOL, SAP, ICF
Time Frame
June 2029
Access Criteria
Given the sensitive nature of the health data contained in the data set, as well as the participation of children, the data and associated documentation will be available to users under a specific data-sharing agreement that provides for: (1) a commitment to using the data only for research purposes and not to identify any individual participant; (2) a commitment to securing the data using appropriate technology; and (3) a commitment to destroying the data after analyses are completed.

Locations