NCT06275230

Brief Summary

The goal of this study is to proliferate human lung stem cell in vitro in order to establish a lung organoid derived from patients with COPD. The main question it aims to answer are:

  • Can human lung stem cell proliferate in vitro.
  • Can a lung organoid derived from patients with COPD be established. Participants will be sampled during pulmonary bronchoscope for organoid establishment.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
30

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Mar 2024

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 17, 2024

Completed
6 days until next milestone

First Posted

Study publicly available on registry

February 23, 2024

Completed
26 days until next milestone

Study Start

First participant enrolled

March 20, 2024

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2025

Completed
Last Updated

February 10, 2025

Status Verified

February 1, 2025

Enrollment Period

1.8 years

First QC Date

February 17, 2024

Last Update Submit

February 7, 2025

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

COPDorganoidhuman lung stem cells

Outcome Measures

Primary Outcomes (1)

  • Number of Patients completed bronchoscope.

    1 day

Study Arms (1)

chronic obstructive pulmonary disease

Patients with COPD undergoing bronchoscope.

Eligibility Criteria

Age18 Years - 55 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)
Sampling MethodNon-Probability Sample
Study Population

COPD Patients with indications of bronchoscopic biopsy

You may qualify if:

  • \. Age under 55, regardless of gender
  • \. Patients with COPD lung disease who are going to undergo bronchoscopic biopsy
  • \. No genetic diseases and other respiratory diseases

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

China-Japan Friendship Hospital

Beijing, Beijing Municipality, 100029, China

RECRUITING

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, ObstructiveLung DiseasesRespiratory Tract DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Central Study Contacts

Mingming Deng, MD

CONTACT

+8618801336854isdeng1017@163.com

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

February 17, 2024

First Posted

February 23, 2024

Study Start

March 20, 2024

Primary Completion

December 31, 2025

Study Completion

December 31, 2025

Last Updated

February 10, 2025

Record last verified: 2025-02

Locations

CN(1)