Chinese Occupational Population Cohort of Lifestyle and Physical Fitness (LiFitChina)

NCT06275009 | Recruiting

• 1 other identifier: 2023-1990
• Study Type: observational
• Target: 18,512
• Locations: 1 country
• Sites: 1

Brief Summary

The incidence and prevalence of metabolic risk factors such as obesity, hypertension, diabetes, and dyslipidemia, as well as cardiovascular diseases (CVD), are continuously rising among the occupational population in China, primarily comprising the middle-aged and young adults. Unhealthy lifestyles and declining physical fitness are independent risk factors affecting cardiovascular health. Additionally, the level of physical fitness is influenced by postnatal lifestyles. Lifestyle factors related to cardiovascular health in the occupational population encompass various aspects, including smoking, physical activity, diet, sleep, psychological stress, etc. These factors may interact or have a synergistic effect, necessitating a comprehensive assessment. This project proposes a prospective cohort study design to establish a monitoring cohort for lifestyle and physical fitness among the occupational population. The study will track and follow individuals with or without any CVD metabolic risk factors, collecting information on general status, lifestyle, physical fitness, and health examination data. Exposure factors such as lifestyle and physical fitness will be measured annually, and the occurrence of CVD-related health outcomes will be observed. The aim is to develop a comprehensive evaluation index for cardiovascular health lifestyle, analyze the direct and indirect impacts of lifestyle and physical fitness on the occurrence and development of CVD, and explore potential mediating and moderating effects of physical fitness in the association between lifestyle and cardiovascular health.

Conditions

Lifestyle; Physical Fitness; Cardiovascular Diseases

Keywords

Lifestyle; physical fitness; Cardiovascular Diseases; cohort

Outcome Measures

Primary Outcomes (1)

• the composite end point of new major adverse cardiovascular events

  including cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization and unstable angina pectoris requiring hospitalization

  10 years

Secondary Outcomes (9)

• new incidence of each major adverse cardiovascular events

  10 years

• new incidence of cancer

  10 years

• new incidence of all-cause death

  10 years

• level of systolic pressure

  10 years

• level of diastolic pressure

  10 years

Eligibility Criteria

• Age: 18 Years - 59 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

occupational person free of cardiovascular disease at baseline in China

You may qualify if:

• adults between 18-59 years of age
• occupational staff
• willing to accept long-term follow-up

You may not qualify if:

• participants with previous CVD history such as myocardial infarction, stroke and severe aortic stenosis;
• with cancer;
• with congenital genetic diseases, or cannot cooperate with the investigation and follow-up due to acquired diseases, such as congenital heart disease, paralysis, deafness, dementia, mental abnormality, developmental retardation, etc.;
• with exercise contraindications;
• duration of pregnancy;
• refuse to sign the informed consent.

Sponsors & Collaborators

• China National Center for Cardiovascular Diseases: lead

Study Sites (1)

Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College

Beijing, Beijing Municipality, China

RECRUITING

MeSH Terms

Conditions

Cardiovascular Diseases

Central Study Contacts

Hongyi Du, MD PhD

CONTACT

86-10-88396087; duhy@bjmu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 17, 2024
• First Posted: February 23, 2024
• Study Start: December 11, 2023
• Primary Completion (Estimated): December 11, 2026
• Study Completion (Estimated): December 11, 2026
• Last Updated: February 28, 2024

Record last verified: 2024-02

Locations

CN (1)