Effects of Krill Oil on Intestinal Integrity Markers in Elite Rowers.

NCT06271434 | Not Yet Recruiting

• 1 other identifier: Olej z kryla/jelita
• Study Type: interventional
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

The study aims to check the influence of krill oil on markers of intestinal injury and intoxication. Research group: the research will be conducted in a homogeneous group of professional rowers (N=30), all competitors qualified for the Polish Youth Rowing Team, aged 18 - 24. The sample size was confiremed in statistical analyses. Rowing performance test will be conducted at the beginning and at the end of the training camp. Participants will perform a test on a rowing ergometer (Concept II, USA); each subject will have to cover a distance of 2000 m in the shortest possible time which is the distance starting in rowing competitions. The results of both tests will be considered in the selection for the championship team; therefore, athletes will be well motivated to perform both tests with maximum effort. Hypotesis: The krill oil will infleunce the gut barier integrity.

Conditions

Endothelial Dysfunction

Keywords

endotoxin; gastrointestinal symtoms; gut permeability

Outcome Measures

Primary Outcomes (5)

• I-FABP (intestinal fatty acid binding protein)

  gut injury (enterocyte)

  Blood samples will be taken from the cubital vein at three-time points: before each stress test (after overnight fasting), one minute after the end of the test, and after a 3-hour recovery period.

• CLDN-3

  gut injury (tight junction)

  Blood samples will be taken from the cubital vein at three-time points: before each stress test (after overnight fasting), one minute after the end of the test, and after a 3-hour recovery period.

• LBP (lipopolysaccharide binding protein)

  endotoxin

  Blood samples will be taken from the cubital vein at three-time points: before each stress test (after overnight fasting), one minute after the end of the test, and after a 3-hour recovery period.

• Catechyloamines, cortisol

  stress hormones

  Blood samples will be taken from the cubital vein at three-time points: before each stress test (after overnight fasting), one minute after the end of the test, and after a 3-hour recovery period.

• CD14

  endotoxin

  Blood samples will be taken from the cubital vein at three-time points: before each stress test (after overnight fasting), one minute after the end of the test, and after a 3-hour recovery period.

Secondary Outcomes (1)

• Food intake

  day before the test, morning before the test

Study Arms (2)

Supplemented

EXPERIMENTAL

(n = 15), who will receive one capsule of a supplement called THYROX (Atlantic krill oil) four times a day. The daily content of krill oil is 2000 mg, including omega-3 fatty acids 350 mg, EPA - 240 mg, DHA - 110 mg, phospholipids - 800 mg, astaxanthin 200 mg. The supplementation period will be six weeks. Intervention: Drug: THYROX (Atlantic krill oil).

Dietary Supplement: THYROX (Atlantic krill oil

Control

EXPERIMENTAL

receiving placebo Intervention: Drug: Placebo

Dietary Supplement: Placebo

Interventions

THYROX (Atlantic krill oil DIETARY_SUPPLEMENT

The daily content of krill oil is 2000 mg, including omega-3 fatty acids 350 mg, EPA - 240 mg, DHA- 110 mg, phospholipids - 800 mg, astaxanthin 200 mg.

Supplemented

Placebo DIETARY_SUPPLEMENT

The control capsules will be made of olive oil of equal size and color.

Control

Eligibility Criteria

• Age: 18 Years - 24 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• training experience of a minimum of five years,
• minimum training time per week 240 minutes,
• all competitors qualified for the Polish Youth Rowing Team,
• completing a food diary,
• finishing 2000m ergometer test.

You may not qualify if:

• Probiotics, prebiotics and antibiotic therapy within the last three months,
• dietary regime,
• gastrointestinal diseases,
• lactose intolerance.

Sponsors & Collaborators

• Poznan University of Physical Education: lead

MeSH Terms

Interventions

Thyroxine

Intervention Hierarchy (Ancestors)

Thyroid Hormones; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists; Amino Acids, Aromatic; Amino Acids, Cyclic; Amino Acids; Amino Acids, Peptides, and Proteins

Study Officials

• Anna Skarpańska-S, professor

  Poznan University of Physical Education

  STUDY DIRECTOR

Central Study Contacts

Hanna Dziewiecka, Msc

CONTACT

606880282; hannadziewiecka@gmail.com

Anna Skarpańska-Stejnborn, professor

CONTACT

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: Triple
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: All competitors will be randomly divided into two groups (double-blind): A. supplemented (n = 15), who will receive one capsule of a supplement called THYROX (Atlantic krill oil) four times a day. B. control (n = 15) receiving placebo. The supplementation period will be six weeks.

Study Record Dates

• First Submitted: February 14, 2024
• First Posted: February 21, 2024
• Study Start: March 23, 2024
• Primary Completion: June 24, 2024
• Study Completion: June 24, 2024
• Last Updated: March 18, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share