Longevity in Russia
Healthy Longevity and Mortality in Long-living Adults: Contributors and Causes - Lifestyle, Socioeconomic Background, and Replicative Aging
1 other identifier
observational
4,000
1 country
1
Brief Summary
This is an observational cohort study of long-living adults (participants aged 90 and above) from the Central Federal District of Russia. The study seeks to determine the genetic and cellular and molecular determinants of healthy longevity and to assess the impact of lifestyle and socioeconomic and environmental factors on healthy longevity. The study is expected to result in the development of a panel of markers of healthy longevity and/or a model of healthy aging based on the analysis of all factors under consideration.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Dec 2019
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 25, 2019
CompletedFirst Submitted
Initial submission to the registry
February 13, 2024
CompletedFirst Posted
Study publicly available on registry
February 20, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2025
CompletedFebruary 22, 2024
February 1, 2024
5 years
February 13, 2024
February 20, 2024
Conditions
Outcome Measures
Primary Outcomes (2)
Mortality among long-living adults
Mortality among long-living adults within at least 1 year after inclusion in the study and factors associated with mortality will be assessed.
at least 1 year after inclusion in the study
Morbidity among long-living adults
Morbidity among long-living adults within at least 1 year after inclusion in the study and factors associated with morbidity will be assessed.
at least 1 year after inclusion in the study
Secondary Outcomes (5)
Aging phenotypes
at least 2 years after inclusion in the study
Social, economic, and medical- history-related determinants
at least 2 years after inclusion in the study
Genetic determinants
at least 2 years after inclusion in the study
Epigenetic determinants
at least 2 years after inclusion in the study
Metagenomic determinants
at least 2 years after inclusion in the study
Study Arms (1)
Long-living individuals
Long-living individuals at least 90 years of age from the Central Federal District of Russia
Eligibility Criteria
The inclusion of participants will be carried out with the involvement of social services, boarding houses for labor veterans, geriatric centers and other geriatric services in the central region of Russia
You may qualify if:
- Informed consent
- years of age or above
You may not qualify if:
- Refusal to participate or to provide informed consent;
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
RUSSIAN CLINICAL AND RESEARCH CENTER OF GERONTOLOGY, Pirogov Russian National Research Medical University of the Ministry of Healthcare of the Russian Federation
Moscow, 129226, Russia
Biospecimen
Whole blood, serum, stool, saliva, urine
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Irina D. Strazhesko, M.D., Ph.D
Pirogov Russian National Research Medical University
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 13, 2024
First Posted
February 20, 2024
Study Start
December 25, 2019
Primary Completion
December 31, 2024
Study Completion
December 31, 2025
Last Updated
February 22, 2024
Record last verified: 2024-02