Dynamics of AMR Spread, Persistence and Evolution Between Humans, Animals and Their Environment

NCT06262009 | Recruiting

• 2 other identifiers: APHP2201012023-A02282-43
• Study Type: observational
• Target: 525
• Locations: 1 country
• Sites: 1

Brief Summary

Humans in contact with animals such as dog owners, may be at risk of antimicrobial resistance (AMR) acquisition. This is the central issue to be investigated in DYASPEO

Conditions

Antibiotic Resistant Strain; Transmission, Close-Contact

Keywords

antibiotic resistant transmission; transmission between dog and human

Outcome Measures

Primary Outcomes (1)

• generation of a list of priorities for future prevention and control strategies to mitigate antimicrobial resistance (AMR) transmission between companion animals and humans

  mathematical models combining all the data (epidemiological, bacteriological, genomic, sociological) gathered in the project

  over the 90 days follow up

Secondary Outcomes (7)

• Rates of AMR acquisitions in one or several housekeepers

  over the 90 days follow up

• A list in nature of changes in dog microbiota

  over the 90 days follow up

• A list in magnitude of changes in dog microbiota

  over the 90 days follow up

• A list in nature of changes in housekeepers microbiota

  over the 90 days follow up

• A list in magnitude of changes in housekeepers microbiota

  over the 90 days follow up

Study Arms (1)

household

House Members (adults and minors) from 175 households owning a dog

Other: human faecal collection; Other: ancillary study

Interventions

human faecal collection OTHER

collecting stools 6 times over a 90 days period and complete a questionnaire at the same times: D1, D7, D15, D30, D60 and D90

household

ancillary study OTHER

interviews and/or ethnographic observations for 50 volunteers

household

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The healthy volunteers (dog owners) will be recruited at a single recruitment centre, which is the National Veterinary School (Maisons-Alfort).

You may qualify if:

• Written consent of all adults and of at least one of the two parents for minors under parental authority. A different information note will be elaborated for each age category (6-10 yr-old, 10-15 yr-old and 16-18 yr-old).
• Owning a dog recorded for a surgery at the National Veterinary School

You may not qualify if:

• Lack of signed informed consent
• Subject in alternating custody
• Subject under legal protection (guardianship)
• Subject deprived of liberty under judicial constraint
• Subject undergoing psychiatric care
• Lack of affiliation to a social security scheme
• Volunteers who do not speak/write French

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead

Study Sites (1)

the National Veterinary School Alfort

Maisons-Alfort, 94700, France

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

human and dog faecal samples

Study Officials

• Jean-Yves Madec, PHD

  ANSES

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jean-Yves Madec, PHD

CONTACT

06 85 08 93 30; Jean-Yves.MADEC@anses.fr

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 8, 2024
• First Posted: February 15, 2024
• Study Start: December 15, 2025
• Primary Completion (Estimated): September 1, 2028
• Study Completion (Estimated): March 1, 2029
• Last Updated: April 23, 2026

Record last verified: 2026-04

Locations

FR (1)