A Study of Sex Differences in Neurocirculatory Control
Sex Differences in Neurocirculatory Control With Obstructive Sleep Apnea
2 other identifiers
observational
60
1 country
1
Brief Summary
The purpose of this study is to investigate potential sex differences in neurocirculatory control of blood pressure in patients with untreated obstructive sleep apnea (OSA).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Oct 2024
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 7, 2024
CompletedFirst Posted
Study publicly available on registry
February 15, 2024
CompletedStudy Start
First participant enrolled
October 29, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
March 1, 2027
January 7, 2026
January 1, 2026
2.3 years
February 7, 2024
January 6, 2026
Conditions
Outcome Measures
Primary Outcomes (3)
Blood pressure
Measured in millimeters of mercury (mmHg).
Baseline
Arterial stiffness
Measured by applanation tonometry reported as aortic pulse wave velocity (m/sec)
Baseline
Endothelial function
Ultrasound assessment of flow-mediated vasodilation of the brachial artery. Brachial artery diameter and blood velocity will be measured after deflation to measure endothelial function.
Baseline
Secondary Outcomes (4)
Sympathetic nerve burst frequency
Baseline
Sympathetic nerve burst incidence
Baseline
Sympathetic nerve burst amplitude (AU)
Baseline
Total muscle sympathetic nerve activity (MSNA)
Baseline
Other Outcomes (7)
Cerebral autoregulation
Baseline
Sympathetic action potentials per burst
Baseline
Sympathetic action potential clusters per burst
Baseline
- +4 more other outcomes
Eligibility Criteria
Subjects with or without untreated obstructive sleep apnea will be recruited from Mayo Clinic in Rochester, MN.
You may qualify if:
- years of age
You may not qualify if:
- Coronary artery disease
- Heart failure
- Pregnancy
- COPD
- Diabetes
- CKD
- Sleep disorders other than OSA
- Shift workers
- Individuals who typically go to sleep after midnight
- Individuals who traveled across ≥2 time zones within one week of study visits
- BMI ≥40.0kg/m2
- Use of nicotine-containing products within the two years preceding study visits
- Use of allopurinol, proton pump inhibitors, or other medications/supplements which interfere with outcome measures
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Joshua Bock, PhD
Mayo Clinic
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
February 7, 2024
First Posted
February 15, 2024
Study Start
October 29, 2024
Primary Completion (Estimated)
March 1, 2027
Study Completion (Estimated)
March 1, 2027
Last Updated
January 7, 2026
Record last verified: 2026-01
Data Sharing
- IPD Sharing
- Will not share