Hypoxemia in the First 24 Hours After Trauma - an Observational Study

NCT06256692 | Completed Results

• 2 other identifiers: p-2023-15008H-23065206
• Study Type: observational
• Target: 165
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to investigate the occurrence of hypoxemia (an abnormally low concentration of oxygen in the blood) in trauma patients within the first 24 hours of hospital admission following arrival to a trauma center. The main questions the study aims to answer are:

• Do trauma patients experience hypoxemia during the initial 24 hours of hospital admission following trauma?
• What is the daily distribution of potential hypoxemic episodes? The investigators expect that hypoxemic episodes will be more frequent during the night (20.00-07.59) than during the day (08.00-19.59) An additional pulse oximeter will be attached to the participants, which measures oxygen saturation in the blood during the first 24 hours of hospital admission after trauma.

Conditions

Trauma; Trauma Injury; Hypoxemia; Hypoxia; Oxygen Deficiency

Outcome Measures

Primary Outcomes (1)

• Occurrence of Hypoxemia

  The primary outcome of the study was the occurrence and distribution of clinically relevant hypoxemic episodes, assessed asincidence rates (IRs) of episodes during daytime (08:00-19:59) and nighttime (20:00-07:59) within the first 24 h of hospitalization following trauma. No universally accepted definition of hypoxemic episodes exists. In this study we defined a clinically relevant hypoxemic episode as SpO2 \< 90%, for \> 5 min.

  24 hours

Secondary Outcomes (3)

• Location of Hypoxemia (Specific Departments)

  24 hours

• Prolonged Hypoxemic Episodes

  24 hours

• Cumulated Time of Hypoxemia

  24 hours

Interventions

Pulse oximeter OTHER

No real intervention, but all study participants will have an additional pulse oximeter attached, to measure oxygen saturation.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All patients with trauma team activation in the trauma bay at Rigshospitalet, including both direct transport and secondary transfers, will be screened for potential inclusion in the study. Patients will be included if they comply with the above eligibility criteria

You may qualify if:

• Patients aged ≥18 years
• Blunt or penetrating mechanism of trauma
• Trauma team activation
• Admission to a ward/ICU from trauma centre

You may not qualify if:

• Patients with a suspicion of carbon monoxide intoxication
• No applicable finger or toe for sensor attachment
• Trauma team activation was cancelled
• No available pulse oximeter at admission

Sponsors & Collaborators

• Rigshospitalet, Denmark: lead
• The Danish Medical Association's Research Fund: collaborator

Study Sites (1)

Rigshospitalet

Copenhagen, Region H, 2100, Denmark

Location

Related Publications (16)

• Zulazmi NA, Arulsamy A, Ali I, Zainal Abidin SA, Othman I, Shaikh MF. The utilization of small non-mammals in traumatic brain injury research: A systematic review. CNS Neurosci Ther. 2021 Apr;27(4):381-402. doi: 10.1111/cns.13590. Epub 2021 Feb 4.

  PMID: 33539662 BACKGROUND

• ATLS Subcommittee; American College of Surgeons' Committee on Trauma; International ATLS working group. Advanced trauma life support (ATLS(R)): the ninth edition. J Trauma Acute Care Surg. 2013 May;74(5):1363-6. doi: 10.1097/TA.0b013e31828b82f5. No abstract available.

  PMID: 23609291 BACKGROUND

• Rhodes CE, Denault D, Varacallo MA. Physiology, Oxygen Transport. 2022 Nov 14. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK538336/

  PMID: 30855920 BACKGROUND

• Lopez-Barneo J, Ortega-Saenz P, Gonzalez-Rodriguez P, Fernandez-Aguera MC, Macias D, Pardal R, Gao L. Oxygen-sensing by arterial chemoreceptors: Mechanisms and medical translation. Mol Aspects Med. 2016 Feb-Mar;47-48:90-108. doi: 10.1016/j.mam.2015.12.002. Epub 2015 Dec 18.

  PMID: 26709054 BACKGROUND

• Singer M, Young PJ, Laffey JG, Asfar P, Taccone FS, Skrifvars MB, Meyhoff CS, Radermacher P. Dangers of hyperoxia. Crit Care. 2021 Dec 19;25(1):440. doi: 10.1186/s13054-021-03815-y.

  PMID: 34924022 BACKGROUND

• Eskesen TG, Baekgaard JS, Steinmetz J, Rasmussen LS. Initial use of supplementary oxygen for trauma patients: a systematic review. BMJ Open. 2018 Jul 6;8(7):e020880. doi: 10.1136/bmjopen-2017-020880.

  PMID: 29982208 BACKGROUND

• Loft FC, Rasmussen SM, Elvekjaer M, Haahr-Raunkjaer C, Sorensen HBD, Aasvang EK, Meyhoff CS; WARD-Project Group. Continuously monitored vital signs for detection of myocardial injury in high-risk patients - An observational study. Acta Anaesthesiol Scand. 2022 Jul;66(6):674-683. doi: 10.1111/aas.14056. Epub 2022 Mar 14.

  PMID: 35247272 BACKGROUND

• Rowat AM, Dennis MS, Wardlaw JM. Hypoxaemia in acute stroke is frequent and worsens outcome. Cerebrovasc Dis. 2006;21(3):166-72. doi: 10.1159/000090528. Epub 2005 Dec 23.

  PMID: 16388191 BACKGROUND

• Sun Z, Sessler DI, Dalton JE, Devereaux PJ, Shahinyan A, Naylor AJ, Hutcherson MT, Finnegan PS, Tandon V, Darvish-Kazem S, Chugh S, Alzayer H, Kurz A. Postoperative Hypoxemia Is Common and Persistent: A Prospective Blinded Observational Study. Anesth Analg. 2015 Sep;121(3):709-715. doi: 10.1213/ANE.0000000000000836.

  PMID: 26287299 BACKGROUND

• Murdock D. Trauma: when there's no time to count. AORN J. 2008 Feb;87(2):322-8. doi: 10.1016/j.aorn.2007.07.008.

  PMID: 18323023 BACKGROUND

• Stassen W, Welzel T. The prevalence of hypotension and hypoxaemia in blunt traumatic brain injury in the prehospital setting of Johannesburg, South Africa: A retrospective chart review. S Afr Med J. 2014 May 12;104(6):424-7. doi: 10.7196/samj.7494.

  PMID: 25214252 BACKGROUND

• Chi JH, Knudson MM, Vassar MJ, McCarthy MC, Shapiro MB, Mallet S, Holcroft JJ, Moncrief H, Noble J, Wisner D, Kaups KL, Bennick LD, Manley GT. Prehospital hypoxia affects outcome in patients with traumatic brain injury: a prospective multicenter study. J Trauma. 2006 Nov;61(5):1134-41. doi: 10.1097/01.ta.0000196644.64653.d8.

  PMID: 17099519 BACKGROUND

• Ali K, Cheek E, Sills S, Crome P, Roffe C. Day-night differences in oxygen saturation and the frequency of desaturations in the first 24 hours in patients with acute stroke. J Stroke Cerebrovasc Dis. 2007 Nov-Dec;16(6):239-44. doi: 10.1016/j.jstrokecerebrovasdis.2007.07.004.

  PMID: 18035240 BACKGROUND

• Fanfulla F, Grassi M, Taurino AE, D'Artavilla Lupo N, Trentin R. The relationship of daytime hypoxemia and nocturnal hypoxia in obstructive sleep apnea syndrome. Sleep. 2008 Feb;31(2):249-55. doi: 10.1093/sleep/31.2.249.

  PMID: 18274273 BACKGROUND

• Galatius-Jensen S, Hansen J, Rasmussen V, Bildsoe J, Therboe M, Rosenberg J. Nocturnal hypoxaemia after myocardial infarction: association with nocturnal myocardial ischaemia and arrhythmias. Br Heart J. 1994 Jul;72(1):23-30. doi: 10.1136/hrt.72.1.23.

  PMID: 8068464 BACKGROUND

• Jensen-Abbew J, Tsuchiya EA, Arleth T, Dinesen F, Queitsch CJ, Von Magius M, Christensen MI, Madsen KPD, Rosenkrantz O, Steinmetz J. Occurrence of Hypoxemia the First Day After Trauma Assessed by Continuous Pulse Oximetry. Acta Anaesthesiol Scand. 2026 Apr;70(4):e70220. doi: 10.1111/aas.70220.

  PMID: 41840458 DERIVED

Related Links

• Data from Traumacentre
• Link on statistics

MeSH Terms

Conditions

Wounds and Injuries; Accidental Injuries; Hypoxia

Condition Hierarchy (Ancestors)

Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Results Point of Contact

• Title: Dr. Jacob Jensen-Abbew
• Organization: Department of Anaesthesiology, Centre of Head and Orthopaedics, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark

jacob.jensen-abbew.01@regionh.dk

+4528733522

Study Officials

• Jacob Steinmetz, MD,professor

  Rigshospitalet, Denmark

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, professor

Study Record Dates

• First Submitted: February 5, 2024
• First Posted: February 13, 2024
• Study Start: February 20, 2024
• Primary Completion: August 24, 2024
• Study Completion: September 5, 2024
• Last Updated: April 21, 2026
• Results First Posted: April 21, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

DK (1)