NCT06253962

Brief Summary

Carotid plaque burden and composition features, particularly lipid necrotic core, are significantly associated with severity of CAD stenosis. This study aims to explore the relationship between various phenotypic patterns of carotid atherosclerosis with the prevalence, phenotype, and severity of coronary atherosclerosis. The patients with chest tightness or chest pain will receive carotid artery ultrasonography before coronary angiography so as to explore the relationship between them.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,000

participants targeted

Target at P75+ for all trials

Timeline
33mo left

Started Feb 2024

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress46%
Feb 2024Dec 2028

First Submitted

Initial submission to the registry

February 4, 2024

Completed
6 days until next milestone

Study Start

First participant enrolled

February 10, 2024

Completed
2 days until next milestone

First Posted

Study publicly available on registry

February 12, 2024

Completed
2.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2026

Expected
2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2028

Last Updated

February 12, 2024

Status Verified

February 1, 2024

Enrollment Period

2.9 years

First QC Date

February 4, 2024

Last Update Submit

February 4, 2024

Conditions

Carotid AtherosclerosisCoronary Atheroscleroses

Outcome Measures

Primary Outcomes (1)

  • MACE

    acute myocardial infarction; heart failure; cardiac death; revascularization

    two years after angiography

Study Arms (2)

carotid atherosclerosis

Other: coronary agiongraphy

without carotid atherosclerosis

Other: coronary agiongraphy

Interventions

coronary agiongraphyOTHER

severity of coronary atherosclerosis

carotid atherosclerosiswithout carotid atherosclerosis

Eligibility Criteria

Age14 Years - 90 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients admitted to receive coronary angiography. Carotid ultrasound performed before angiography.

You may qualify if:

  • patients receive carotid ultrasound and coronary angiography

You may not qualify if:

  • None

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

180 Fenglin Road

Shanghai, 200032, China

RECRUITING

MeSH Terms

Conditions

Carotid Artery DiseasesCoronary Artery Disease

Condition Hierarchy (Ancestors)

Cerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular DiseasesCoronary DiseaseMyocardial IschemiaHeart DiseasesArteriosclerosisArterial Occlusive Diseases

Central Study Contacts

Danbo Lu, PhD

CONTACT

+86 021 64041990lu.danbo@zs-hospital.sh.cn

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 4, 2024

First Posted

February 12, 2024

Study Start

February 10, 2024

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

December 31, 2028

Last Updated

February 12, 2024

Record last verified: 2024-02

Locations

CN(1)