Conceptualisation of a Network Approach to Complete the Classification of Eating Disorders With the Aim of Better Personalising Their Management

NCT06252688 | Not Yet Recruiting DMC

• 1 other identifier: RECHMPL23_0261
• Study Type: interventional
• Target: 840
• Locations: 0 countries
• Sites: N/A

Brief Summary

Eating disorders (EDBs) are mental disorders with a great impact on the lives of individuals as well as a great cost imposed on society. The treatments currently available rely on different forms of psychotherapies with an unsatisfactory response rate as well as a considerable relapse rate . One of the reasons underlying the low success of available therapeutic modalities would be the heterogeneity of the clinical presentation of EDs, making their classification and the personalization of their treatment more difficult.The investigators hypothesize that a secondarily dimensional classification approach (respecting the categorical classification currently in use) of EDs based on the different dimensions disturbed in these disorders as well as in their comorbidities, would better represent their nosographic reality, which could provide patients with more personalized and potentially more effective care.

Conditions

Eating Disorders; Eating Disorder Binge

Keywords

Anorexia nervosa; Bulimia; Binge eating disorders; Neuropsychology; Neurocognitiond; Daily functioning

Outcome Measures

Primary Outcomes (2)

• Eating Disorders Inventory (EDI-2)

  self-questionnaire of 91 items aimed at evaluating attitudes and behaviors related to food and allowing the identification of 11 dimensions: search for thinness, bulimia, body dissatisfaction, inefficiency, perfectionism, interpersonal distrust, interoceptive awareness, fear of maturity , asceticism, impulse control, social insecurity. The higher the subscore, the more severely impaired the dimension concerned is.

  Baseline

• Eating Disorder Examination Questionnaire (EDE-Q)

  Self-reported version of the gold-standard clinical interview for ED assessing the intensity of eating symptoms over the last 28 days. A total score as well as 4 sub-scores (restriction, diet, weight, shape) varying from 0 to 6 are thus obtained.

  Baseline

Secondary Outcomes (26)

• Symptomatic dimensions of Eating Disorder Examination Questionnaire (EDEQ)

  baseline

• Body Shape Questionnaire (BSAQ-34)

  baseline

• Yale Food Addiction Scale (YFAS)

  baseline

• Sociocultural Attitudes Towards Appearance Scale (SATAQ-4)

  baseline

• Female drive for muscularity scale (FDMS)

  baseline

Study Arms (1)

Participants

OTHER

All participants performed the same evaluation: clinical and neuropsychological assessment. All of them are patients with an eating disorder.

Behavioral: Ambulatory cares in a day-hospital (Lapeyronie, Montpellier) specialized in the evaluation of eating disorders.

Interventions

Ambulatory cares in a day-hospital (Lapeyronie, Montpellier) specialized in the evaluation of eating disorders. BEHAVIORAL

All patients assessed in the day-hospital will permormed the same evaluation : * Blood sampling * Calorimetry * Osteodensotometry * Psychiatric assement * Endocrinologic assessment * Dietetic assessment * Neuropsychological assessment * Self-questionnaires With the patient agreement, a biological collection will be constituted. The objective is the subsequent study of biological factors involved in eating disorders (in particular genetic factors)

Participants

Eligibility Criteria

• Age: 15 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Patient with an eating disorder according to DSM-V criteria
• Patient aged from 15 to 65 years
• Patient who performs the day-hospital evaluation
• Patient affiliated to a French social security system
• Patient able to understand the nature, the aim and the methodology of the study
• For minor one of the legal guardians gave his consent

You may not qualify if:

• Patient in an unstable somatic state (eg severe metabolic disorder making impossible or unreliable neuropsychological assessments)
• Patient's refusal to participate
• Patient protected by law (guardianship or curatorship)\*
• Pregnant or nursing women. A dosage of βHCG will be performed to ensure the absence of pregnancy

Sponsors & Collaborators

• University Hospital, Montpellier: lead

MeSH Terms

Conditions

Feeding and Eating Disorders; Binge-Eating Disorder; Anorexia Nervosa; Bulimia

Condition Hierarchy (Ancestors)

Signs and Symptoms, Digestive; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders; Hyperphagia

Central Study Contacts

Sébastien GUILLAUME, PhD

CONTACT

+33 4 67 33 82 89; s-guillaume@chu-montpellier.fr

Maude SENEQUE, MD

CONTACT

+33 0467335663; m-senequehaize@chu-montpellier.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 17, 2023
• First Posted: February 12, 2024
• Study Start: February 15, 2024
• Primary Completion (Estimated): November 15, 2031
• Study Completion (Estimated): November 15, 2031
• Last Updated: February 12, 2024

Record last verified: 2023-09