Oscillatory Activity in Basal Ganglia Circuits During Normal and Pathological Movement

NCT06241924 | Recruiting

• 1 other identifier: CHUBX 2022/80
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The expression of hypokinetic and hyperkinetic motor symptoms is accompanied by pathological synchronous oscillations of neuronal activity in this cortico-subcortical network with a wide frequency range. The purpose of this research is to study cortico-subcortical oscillations and their synchronization in two pathologies emblematic of hypokinetic (Parkinson's disease) and hyperkinetic (epilepsies) phenomena using a simple motor task and comparing different situations.

Conditions

Parkinson Disease; Epilepsy

Keywords

Focal seizure; Parkinson disease; Hyperkinetic seizures; Hypokinetic disorders; Dyskinesia; Networks; Basal ganglia

Outcome Measures

Primary Outcomes (1)

• difference in the cortico-subcortical electrophysiological coherence value

  difference in the cortico-subcortical electrophysiological coherence value between normal movement (control condition) and hypo- or hyperkinetic pathological movement

  Day 1

Study Arms (2)

Epilepsy

EXPERIMENTAL

Procedure: Stereo-electro-encephalography (SEEG)

parkinson disease

EXPERIMENTAL

Procedure: High Resolution Electroencephalogram (EEG-HR)

Interventions

High Resolution Electroencephalogram (EEG-HR) PROCEDURE

Local field potentials (LFP) recording using EEG-HR

parkinson disease

Stereo-electro-encephalography (SEEG) PROCEDURE

Local field potentials (LFP) recording using sEEG

Epilepsy

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Male or Female
• Between 18 and 75 years of age
• With Parkinson's disease and already operated with implantation of electrodes in the Subthalamic nucleus connected to a PERCEPT (TM) device.
• Giving free, informed, written consent signed by the participant and the investigator Or
• With drug-resistant epilepsy and benefiting from a phase II pre-surgical assessment with intracerebral electrophysiological exploration by stereo-EEG
• With at least one electrode exploring the basal ganglia or the thalamus.
• Able to perform the simple motor task
• Affiliated or beneficiary of a social security scheme;
• Giving free, informed, written consent signed by the participant and the investigator

You may not qualify if:

• Be incapable of giving consent personally
• Be subject to a legal protection measure or be placed under judicial protection;
• Being pregnant or breastfeeding
• Present a serious and/or decompensated somatic or psychiatric illness

Sponsors & Collaborators

• University Hospital, Bordeaux: lead

Study Sites (1)

CHU de Bordeaux

Bordeaux, 33076, France

RECRUITING

MeSH Terms

Conditions

Parkinson Disease; Epilepsy; Seizures; Dyskinesias

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Jérôme AUPY, Docteur

  University Hospital, Bordeaux

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jérôme AUPY, Docteur

CONTACT

05 56 71 43 33; jerome.aupy@u-bordeaux.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 26, 2024
• First Posted: February 5, 2024
• Study Start: February 5, 2024
• Primary Completion (Estimated): February 5, 2027
• Study Completion (Estimated): February 5, 2027
• Last Updated: July 23, 2025

Record last verified: 2025-07

Locations

FR (1)