Insulin Resistance Indices and Coronary Artery Disease

NCT06237244 | Completed DMC

• 1 other identifier: IR.SUMS.MED.REC.1402.252
• Study Type: observational
• Target: 1,017
• Locations: 1 country
• Sites: 1

Brief Summary

In this retrospective study from professor Kojuri clinic registry, total number of 1017 patients with first angiography were included and all data were recorded from registry. Insulin resistance was calculated using laboratory data

Conditions

Insulin Resistance; Coronary Artery Disease

Keywords

coronary artery disease; insulin resistance; triglyceride glucose index

Outcome Measures

Primary Outcomes (2)

• insulin resistance index: level of triglyceride to glucose ratio from blood sample

  correlation of coronary artery disease and triglyceride glucose ratio in blood laboratory tests

  3 years

• insulin resistance index: Level of triglyceride to HDL ratio from blood sample

  correlation of coronary artery disease and triglyceride to HDL level ratio in blood laboratory sample

  3 years

Secondary Outcomes (1)

• metabolic syndrome

  3 years

Study Arms (2)

coronary artery disease

patients with coronary angiography of at least one vessel with more than 50% stenosis

Diagnostic Test: triglyceride to glucose ratio; Diagnostic Test: triglycerdie to HDL ratio

no coronary artery disease

patient with no stenosis in coronary angiography

Diagnostic Test: triglyceride to glucose ratio; Diagnostic Test: triglycerdie to HDL ratio

Interventions

triglyceride to glucose ratio DIAGNOSTIC_TEST

Ratio of triglyceride level to glucose

coronary artery disease; no coronary artery disease

triglycerdie to HDL ratio DIAGNOSTIC_TEST

Ratio of triglyceride to HDL cholesterol

coronary artery disease; no coronary artery disease

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients more than 18 years old referred for evaluation of coronary artery disease for their first time

You may qualify if:

• patients with age more than 18 years and having undergone coronary angiography

You may not qualify if:

• incomplete data
• history of prior coronary angiography or revascularization (percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG))
• serum creatinine \> 1.4 mg/dL
• history of chronic kidney disease (CKD)
• cancer,

Sponsors & Collaborators

• Shiraz University of Medical Sciences: lead

Study Sites (1)

Shiraz University of Medical Sciences

Shiraz, Fars, 7134814336, Iran

Location

Related Publications (1)

• Jahangiri S, Mosalamiaghili SA, Heydarzadeh R, Yousefzadeh M, Golchin Vafa R, Zarifkar H, Assadian K, Sohrabizadeh S, Zarifkar H, Sadeghi M, Hosseini N, Montaseri M, Hosseini SA, Kojuri J. Predicting the presence and severity of coronary artery disease using surrogate markers of insulin resistance: A cross-sectional study. ARYA Atheroscler. 2025;21(1):44-53. doi: 10.48305/arya.2025.42573.2960.

  PMID: 40401209 DERIVED

MeSH Terms

Conditions

Insulin Resistance; Coronary Artery Disease

Condition Hierarchy (Ancestors)

Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Officials

• Javad Kojuri, MD. MS.

  Professor kojuri cardiology clinic

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Target Duration: 3 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: January 23, 2024
• First Posted: February 1, 2024
• Study Start: December 1, 2018
• Primary Completion: May 1, 2023
• Study Completion: September 1, 2023
• Last Updated: February 5, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

IR (1)