Diagnostic CT Palliative Radiotherapy: Feasibility Study of Treating Bone Metastases Without a CT Simulation

NCT06235034 | Unknown DMC

• 1 other identifier: dCT-PRT
• Study Type: interventional
• Target: 10
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this non-randomized, prospective study is to assess the feasibility of planning and delivering conventional palliative radiotherapy to bone metastases on previously available diagnostic CT scans (dCT). Objectives:1) dosimetric accuracy of palliative radiotherapy designed on a dCT compared to a CT simulation 2) assess suitability of patient set up using surface landmarks and kilo voltage (kV) imaging 3) determine the proportion of patients who can receive radiotherapy designed on a dCT 4) confirm eligibility criteria for appropriate patients in clinical practice All enrolled patients will undergo a CT simulation with tattoos as per current standard of care.The radiation oncologist will place fields on the dCT and CT simulation. Radiotherapy will be planned on both CT scans and reviewed for quality by both the radiation oncologist and medical physicist.

Conditions

Bone Metastases

Keywords

Palliative Radiation; CT Simulation

Outcome Measures

Primary Outcomes (4)

• dosimetric accuracy of palliative radiotherapy designed on a dCT compared to a CT simulation

  1 Year

• assess suitability of patient set up using surface landmarks and kilo voltage (kV) imaging

  1 Year

• determine the proportion of patients who can receive radiotherapy designed on a dCT

  1 Year

• confirm eligibility criteria for appropriate patients in clinical practice

  1 Year

Secondary Outcomes (2)

• patient satisfaction with treatment process

  1 Year

• evaluate carbon footprint savings of dCT-RT workflow

  1 Year

Study Arms (1)

diagnostic CT

EXPERIMENTAL

patients will have their palliative radiotherapy designed on their diagnostic CT

Other: Diagnostic CT

Interventions

Diagnostic CT OTHER

radiotherapy will be designed on diagnostic CT. If plan is of sufficient quality, RT will be delivered to patient

diagnostic CT

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients \>18 years of age
• Able to provide informed consent
• Patient able to lie supine comfortably
• Patient is receiving conventional palliative radiotherapy (Parallel Opposed Pair or single field over 8/1 or 20/5) for the treatment of bone metastases in the following locations: T5-lumbosacral spine, Bony pelvis
• Patient has a diagnostic CT scan which includes the anatomic location to be treated that is within 28 days of enrollment
• Quality of dCT scan is deemed sufficient for RT planning as determined by medical physicist and RT

You may not qualify if:

• Patient unwilling, unable to consent to treatment/study
• Any contraindications to receiving radiotherapy including pregnancy
• Oncologic emergencies, on call treatments, or any indications for urgent radiotherapy
• Inability to comfortably maintain and immobilized position due to uncontrolled pain or co-morbidities
• Cases requiring VMAT planning or complex planning to account for prior courses of radiotherapy
• Cases using non-conventional palliative radiotherapy fractionations
• Anatomic sites outside of the pre-defined criteria above

Sponsors & Collaborators

• British Columbia Cancer Agency: lead

Central Study Contacts

Shilo Lefresne, MD FRCPC

CONTACT

6048776000; SLefresne@bccancer.bc.ca

Sandy Chang

CONTACT

6048776000; Sandy.Chang@bccancer.bc.ca

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 21, 2023
• First Posted: January 31, 2024
• Study Start: January 20, 2024
• Primary Completion: November 30, 2024
• Study Completion: April 30, 2025
• Last Updated: January 31, 2024

Record last verified: 2023-12