Relationship Between Serum Vitamin D Levels and Postherpetic Neuralgia.

NCT06232486 | Active Not Recruiting

• 1 other identifier: TJ-IRB20231251
• Study Type: observational
• Target: 144
• Locations: 1 country
• Sites: 1

Brief Summary

1. 1.The correlations of serum vitamin D level, serum calcium level and osteoporosis degree with disease severity, treatment response, incidence of Post-Herpes zoster(PHN) and disease prognosis in Herpes zoster(HZ) patients were studied.
2. 2.To investigate the role of inflammation-related factors and immune-related factors in the occurrence and development of HZ mediated by low vitamin D level.

Conditions

Postherpetic Neuralgia

Keywords

Herpes zoster,post-herpes zoster,Vitamin D,

Outcome Measures

Primary Outcomes (1)

• Serum 25-hydroxyvitamin D levels

  Vitamin D deficiency: \< 20 nmol/L. Vitamin D deficiency: 20-30 nmol/L. Normal vitamin D: \> 30 nmol/L.

  herpetic neuralgia <3 month

Secondary Outcomes (35)

• C-reactive protein

  Day 2 in the hospital

• Lymphocytes

  Day 2 in the hospital

• Red blood cell distribution width,RDM(fl)

  Day 2 in the hospital

• Red blood cell count,RBC

  Day 2 in the hospital

• Mean red cell volum,MVC

  Day 2 in the hospital

Study Arms (1)

Herpes zoster patients

The patient was diagnosed with herpetic neuralgia and the course of disease was ≤3 months;

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with herpes zoster who were hospitalized in the Department of Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology from October 2023 to October 2025 were selected.

You may qualify if:

• Age ≥18 years.
• The patient was diagnosed with herpetic neuralgia and the course of disease was ≤3 months.
• Can cooperate with the completion of inquiry and scale evaluation.

You may not qualify if:

• Severe spinal disease (fracture, malignancy, acute or chronic infection) confirmed by previous spinal surgery or imaging.
• Previous history of head trauma.
• Have autoimmune diseases (systemic lupus erythematosus, rheumatoid arthritis, leucothrombocytopenia).
• Suffering from mental disorders, intellectual disability, epilepsy and other diseases.
• A history of substance abuse, drug abuse or alcohol abuse.
• Pregnant or breastfeeding women.
• And recent participation in other clinical studies.

Sponsors & Collaborators

• Feng Gao: lead

Study Sites (1)

Tongji Hospital

Wuhan, Hubei, 430030, China

Location

MeSH Terms

Conditions

Neuralgia, Postherpetic

Condition Hierarchy (Ancestors)

Neuralgia; Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: December 25, 2023
• First Posted: January 30, 2024
• Study Start: December 1, 2023
• Primary Completion: December 31, 2025
• Study Completion (Estimated): December 31, 2026
• Last Updated: January 30, 2024

Record last verified: 2024-01

Locations

CN (1)