Correlation Analysis Between Mostcare Parameters and Spontaneous Breathing Trial in Patients After Cardiac Surgery

NCT06230497 | Completed

• 1 other identifier: 216-4
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Cardiac output (CO) monitoring is of primary importance in high-risk surgery and critically ill patients. Intermittent thermodilution (ThD) by means of a pulmonary artery catheter (PAC) was invasiveness, the occurrence of complications, and inability to estimate CO on a beat-by-beat basis may explain the reduction in routine use. Echocardiography is now widely used. However, a poor acoustic window, inaccurate diameter calculations, and difficulty maintaining the angle of insonation and blood flow within the recommended values may lead to inaccuracy in CO estimation.Pulse contour methods (PCMs) are commonly used as they seem to fulfill most of the characteristics of an "ideal" hemodynamic monitoring system. Mostcare can continuously and real-time monitor important circulatory indicators such as cardiac output, peripheral vascular resistance index (SVRI), cardiovascular impedance (Ztot), cardiac cycle efficiency (CCE), and maximum pressure gradient (dp/dt MAX). It may help identify the causes of difficulty in weaning patients from ventilators after cardiac surgery.

Conditions

Post-cardiac Surgery; Ventilator Weaning

Keywords

Post-cardiac Surgery; Ventilator weaning; Mostcare; ressure recording analytical method

Outcome Measures

Primary Outcomes (1)

• The Cardiac Cycle Efficiency (CCE)(unit)

  The Cardiac Cycle Efficiency (CCE) parameter provided by Mostcare is a comprehensive index of cardiac function that takes into account the mechanical and geometric properties of the heart. It integrates the changes in pressure and volume throughout the cardiac cycle to provide a single value that reflects the heart's efficiency. CCE is computed as CCE= Wsys/Wbeat\*K(t), where Wsys is the power function from the systolic pressure wave, Wbeat is the power function from the entire cardiac cycle pressure wave, and K(t) is the ratio of mean pressure expected over mean pressure measured.

  Day1

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients admitted to the ICU after cardiac surgery and mechanically ventilated for more than 24 hours

You may qualify if:

• Patients admitted to the ICU after cardiac surgery
• mechanically ventilated for more than 24 hours

You may not qualify if:

• the presence of pathologies that could affect the quality and reliability of the arterial pulse transmission (aortic valve diseases, aortic aneurysm or dissection, thoracic outlet syndrome);
• arrhythmias;
• hemodynamic instability;
• age less than 18 years or more than 80 years

Sponsors & Collaborators

• Peking Union Medical College Hospital: lead

Study Sites (1)

Department of Critical Care Medicine of pekin union medical college hospital

Beijing, Beijing Municipality, 100730, China

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 17, 2024
• First Posted: January 30, 2024
• Study Start: May 1, 2024
• Primary Completion: October 1, 2024
• Study Completion: October 10, 2024
• Last Updated: January 14, 2025

Record last verified: 2024-03

Locations

CN (1)