NCT06228729

Brief Summary

This study aims to prospectively evaluate the relationship between changes in EEG and hormonal responses induced by endotracheal intubation and surgical incision following general anesthesia.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
52

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Apr 2025

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 18, 2024

Completed
11 days until next milestone

First Posted

Study publicly available on registry

January 29, 2024

Completed
1.2 years until next milestone

Study Start

First participant enrolled

April 1, 2025

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 28, 2025

Completed
24 days until next milestone

Study Completion

Last participant's last visit for all outcomes

November 21, 2025

Completed
Last Updated

January 6, 2026

Status Verified

December 1, 2025

Enrollment Period

7 months

First QC Date

January 18, 2024

Last Update Submit

December 31, 2025

Conditions

Abdominal SurgeryEndotracheal IntubationSurgical IncisionElectroencephalogram

Outcome Measures

Primary Outcomes (1)

  • Association between band power changes in EEG and hormone respones caused by endotracheal intubation

    from the start of anesthesia induction to one minute after endotracheal intubation

Secondary Outcomes (1)

  • Association between band power changes in EEG and hormone respones caused by surgical incision

    from the start of anesthesia induction to one minute after surgical incision

Interventions

Endotracheal intubationPROCEDURE

Inserting endotracheal tube into the trachea

Eligibility Criteria

Age20 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Adult patients undergoing open abdominal surgery and endotracheal intubation under general anesthesia

You may qualify if:

  • \) Patients scheduled to undergo open abdominal surgery under general anesthesia with endotracheal intubation.
  • \) Patients requiring invasive blood pressure monitoring during surgery

You may not qualify if:

  • \) Patients transferred to the intensive care unit after surgery
  • \) Surgery duration of less than one hour
  • \) Patients with neurological underlying conditions
  • \) Patients on chronic use of psychotropic medications and opioid drugs
  • \) Emergency surgery

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Seoul National University Hospital

Seoul, 03080, South Korea

Location

MeSH Terms

Conditions

Surgical Wound

Interventions

Intubation, Intratracheal

Condition Hierarchy (Ancestors)

Wounds and Injuries

Intervention Hierarchy (Ancestors)

Airway ManagementTherapeuticsIntubationInvestigative Techniques

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Clinical assistant professor

Study Record Dates

First Submitted

January 18, 2024

First Posted

January 29, 2024

Study Start

April 1, 2025

Primary Completion

October 28, 2025

Study Completion

November 21, 2025

Last Updated

January 6, 2026

Record last verified: 2025-12

Locations

KR(1)