INTEGRAL Study: A Longitudinal Study of Surgeries and Lasers in Glaucoma

NCT06227299 | Enrolling By Invitation

• 1 other identifier: INTEGRAL
• Study Type: observational
• Target: 5,000
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to create a large-scale register of all glaucoma patients diagnosed, followed and treated in a large tertiary centre specialising in glaucoma, in order to analyse whether specific factors influence the progression of the disease or guide our choice of treatment. This should lead to a better understanding of the disease and the factors to be taken into account when choosing the best treatment option for each patient, leading to safer, more effective and patient-centred care.

Conditions

Glaucoma

Outcome Measures

Primary Outcomes (2)

• IOP changes

  intraocular pressure (IOP) values compared to baseline

  2 months, 6 months, 12 months, 24 months, 36 months, 48 months, 60 months

• Number of molecules

  • number of IOP-lowering medications required to maintain the IOP within therapeutic targets compared to baseline

  2 months, 6 months, 12 months, 24 months, 36 months, 48 months, 60 months

Study Arms (1)

Glaucoma patients

Patients with glaucoma

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The register includes all patients diagnosed with glaucoma (primary, secondary, open and closed-angle) who received treatment at the Glaucoma Centre, at Montchoisi Clinic and Swiss Visio Montchoisi, Lausanne since 2014. There is no limit to the number of patients included in the register.

You may qualify if:

• Diagnosis of glaucoma (open-angle, closed-angle, primary or secondary) or ocular hypertension (IOP \> 24 mmHg, medicated or not)
• Patients who received treatment (medical, laser or surgical) at the Glaucoma Centre, Montchoisi Clinic and Swiss Visio Montchoisi
• Age: 18 years old or older
• Able and willing to provide informed written or verbal consent

Sponsors & Collaborators

• Swiss Glaucoma Research Foundation: lead

Study Sites (1)

Swiss Visio Montchoisi

Lausanne, Canton of Vaud, 1006, Switzerland

Location

MeSH Terms

Conditions

Glaucoma

Condition Hierarchy (Ancestors)

Ocular Hypertension; Eye Diseases

Study Officials

• Kaweh Mansouri, MD

  Swiss Glaucoma Research Foundation

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 10 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 17, 2024
• First Posted: January 26, 2024
• Study Start: May 29, 2018
• Primary Completion: August 30, 2018
• Study Completion (Estimated): January 1, 2030
• Last Updated: May 14, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)