Body Massage Oil, Facial Mask, and Ready-to-drink Jelly From Snake Fruit

NCT06227260 | Completed Phase 2 DMC

• 1 other identifier: IRB1-028/2566
• Study Type: interventional
• Target: 178
• Locations: 1 country
• Sites: 1

Brief Summary

This study consisted of three sub-studies including 1) development and evaluation of body massage oil from Snake fruit on skin moisture, elasticity, oiliness, and melanin in healthy participants 2) development and evaluation of facial mask from Snake fruit on skin moisture, elasticity, oiliness, and melanin in healthy participants and 3) development and evaluation of ready-to-drink jelly from Snake fruit on controlling blood glucose and endurance time in healthy participants.

Conditions

Body Massage Oil From Snake Fruit; Facial Mask From Snake Fruit; Jelly From Snake Fruit

Outcome Measures

Primary Outcomes (8)

• Level of skin moisture

  Study 1 and 2 determined level of skin moisture in arbitrary unit (no unit) using Multiprobe Adapter System with Corneometer® CM 825 probe

  Before intervention, immediately after intervention, ends of week 4, week 8, and week 12

• Level of skin elasticity

  Study 1 and 2 determined level of skin elasticity in arbitrary unit (no unit) using Multiprobe Adapter System with Cutometer® 580 probe

  Before intervention, immediately after intervention, ends of week 4, week 8, and week 12

• Level of skin oiliness

  Study 1 and 2 determined level of skin oiliness in arbitrary unit (no unit) using Multiprobe Adapter System with Sebumeter® SM 815 probe

  Before intervention, immediately after intervention, ends of week 4, week 8, and week 12

• Level of skin melanin

  Study 1 and 2 determined level of skin melanin in arbitrary unit (no unit) using Multiprobe Adapter System with Mexameter® MX18 probe

  Before intervention, immediately after intervention, ends of week 4, week 8, and week 12

• Level of blood glucose

  Study 3.1 determined level of blood glucose in mg/dL unit

  Before jelly consumption and after jelly consumption at 30, 60, 90, and 120 minutes

• Endurance time

  Study 3.2 determined endurance time by cycling at 60% of maximum oxygen consumption as long as possible (time to exhaustion test)

  After jelly consumption for 30 minutes

• Concentration of interferon-gamma

  Study 3.2 determined concentration of interferon-gamma in serum in pg (picogram)/mL unit

  Before and immediately after endurance time test

• Concentration of tumor necrosis factor-alpha

  Study 3.2 determined concentration of tumor necrosis factor-alpha in serum in pg (picogram)/mL unit

  Before and immediately after endurance time test

Study Arms (6)

Study 1: Thai massage

ACTIVE COMPARATOR

Participants were randomized to receive an arm. In this arm, participants received Thai massage without any oil for 1 hour/day, 1 day/week for 12 weeks. Massage was performed at Burapha University by an expert.

Other: Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juice

Study 1: Thai massage with pure coconut oil

ACTIVE COMPARATOR

Participants were randomized to receive an arm. In this arm, participants received Thai massage with pure coconut oil which is a popular oil used in spa for 1 hour/day, 1 day/week for 12 weeks. Massage was performed at Burapha University by an expert.

Other: Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juice

Study 1: Thai massage with oil mixed with Snake fruit extract

EXPERIMENTAL

Participants were randomized to receive an arm. In this arm, participants received Thai massage with oil mixed with Snake fruit extract for 1 hour/day, 1 day/week for 12 weeks. Massage was performed at Burapha University by an expert.

Other: Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juice

Study 2: Facial mask with Snake fruit extract

EXPERIMENTAL

Participants were randomized to receive an arm. In this arm, participants received home-based program facial mask with Snake fruit extract for 30 min/day, 2 days/week for 12 weeks.

Other: Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juice

Study 3: Control jelly

ACTIVE COMPARATOR

Participants were randomized to receive an arm. In this arm, participants consumed with control jelly at 3.5 g/kg body weight. Consumption was taken at Burapha University.

Other: Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juice

Study 3: Jelly with Snake fruit juice

EXPERIMENTAL

Participants were randomized to receive an arm. In this arm, participants consumed with jelly with Snake fruit juice at 3.5 g/kg body weight. Consumption was taken at Burapha University.

Other: Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juice

Interventions

Thai massage, Thai massage with pure coconut oil, Thai massage with oil mixed with Snake fruit extract, Control, Facial mask with Snake fruit extract, Control jelly, Jelly with Snake fruit juice OTHER

Interventions among the 3 studies were categorized as other.

Study 1: Thai massage; Study 1: Thai massage with oil mixed with Snake fruit extract; Study 1: Thai massage with pure coconut oil; Study 2: Facial mask with Snake fruit extract; Study 3: Control jelly; Study 3: Jelly with Snake fruit juice

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Man or woman
• Aged between 18 to 35 years
• Healthy
• Interested in body massage with oil or facial mask or jelly from Snake fruit

You may not qualify if:

• History of adverse effects from body massage
• Skin allergy
• Skin disorders
• Skin wounds
• History of allergy to coconut or plant oil
• History of allergy to facial mask, i.e., mask from fruit
• History of allergy to Snake fruit or gelatin
• Signs or symptoms of fever or infection
• Abnormal body mass index
• Regular smokers or alcohol drinkers (\>2 times per week)
• Regular exerciser (\>2 times per week or \>150 min per week)
• Regular intake of dietary supplements, i.e., vitamins, antioxidants
• Hypertension, diabetes, cardiovascular disease, respiratory disease, endocrine disease, neuromuscular disease, musculoskeletal disease, liver disease, renal disease, immune disease, infectious disease, or cancer

Sponsors & Collaborators

• Burapha University: lead

Study Sites (1)

Faculty of Allied Health Sciences, Burapha University

Mueang, Changwat Chon Buri, 20131, Thailand

Location

Related Publications (1)

• Boonla O, Chancharoen P, Padkao T, Teethaisong Y, Tangwattanachuleeporn M, Koowattanatianchai S, Prasertsri P. Acute ingestion of snake fruit jelly improves glycemic response, enhances endurance performance and antioxidant defense, and reduces inflammatory markers in healthy adults. J Int Soc Sports Nutr. 2025 Dec;22(1):2579029. doi: 10.1080/15502783.2025.2579029. Epub 2025 Oct 26.

  PMID: 41139389 DERIVED

MeSH Terms

Interventions

Medicine, Thai Traditional; Gels

Intervention Hierarchy (Ancestors)

Medicine, Traditional; Complementary Therapies; Therapeutics; Colloids; Complex Mixtures; Dosage Forms; Pharmaceutical Preparations

Study Officials

• Piyapong Prasertsri, Ph.D.

  Burapha University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor Dr.

Model Details: Study 1 and 2 were parallel model, study 3 was crossover model.

Study Record Dates

• First Submitted: December 21, 2023
• First Posted: January 26, 2024
• Study Start: March 20, 2023
• Primary Completion: October 30, 2023
• Study Completion: October 31, 2023
• Last Updated: January 26, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will not share

Locations

TH (1)