Role of Ultrasound Guided Transversus Abdominis Plane Block in Pain Control After Hepatectomy

NCT06224179 | Unknown DMC

• 1 other identifier: M S 96/2021
• Study Type: interventional
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

Inadequately managed acute pain following abdominal surgery originates from somatic pain signals in the abdominal wall and is linked to various unfavorable postoperative outcomes. These consequences encompass patient distress, respiratory complications, delirium, myocardial ischemia, extended hospital stays, an elevated risk of chronic pain, heightened analgesic consumption, delayed bowel function, and an increased need for rescue analgesics. This study aims to assess the postoperative analgesic efficacy of ultrasound-guided Transversus Abdominis Plane (TAP) block using oblique subcostal and posterior approaches in hepatectomy.

Conditions

Analgesia

Outcome Measures

Primary Outcomes (1)

• postoperative analgesia (VAS) during the 1st 24 hours in ICU

  Pain will be assessed on admission and at 2, 4, 8, 12 and 24 hours at rest and with passive flexion of hip and knee joint using visual analogue scale (VAS) ranging from 0 for no pain to 10 for worst pain.

  24 hours

Study Arms (2)

Group A

EXPERIMENTAL

Group A received ultrasound guided subcostal TAP block with 30 ml of local anesthetics and additives

Procedure: ultrasound guided subcostal TAP block

Group B

EXPERIMENTAL

Group B received ultrasound guided both subcostal and posterior TAP block with 30 ml of local anesthetics and additives at each side

Procedure: ultrasound guided combined posterior and subcostal TAP block

Interventions

ultrasound guided subcostal TAP block PROCEDURE

patients will be randomly divided into two groups using a computer generated random number chart. Group A received ultrasound guided subcostal TAP block,

Group A

ultrasound guided combined posterior and subcostal TAP block PROCEDURE

patients will be randomly divided into two groups using a computer generated random number chart. Group B received ultrasound guided combined posterior and subcostal TAP block,

Group B

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• ASA I and II patients. aged 18 to 50 years. 70 to 80 kg.

You may not qualify if:

• patients under 18 years of age.
• History of Allergic reactions to study drugs.
• Opioid or analgesic abuse, and chronic treatment with opioids, or non-steroidal anti-inflammatory drugs.
• History of bleeding tendency or coagulopathy .

Sponsors & Collaborators

• Ain Shams University: lead

MeSH Terms

Conditions

Agnosia

Condition Hierarchy (Ancestors)

Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Ahmed El-Dolah, lecturer of Anesthesia

CONTACT

+20111113077; a_wagih82@yahoo.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: lecturer of anesthesia

Study Record Dates

• First Submitted: January 17, 2024
• First Posted: January 25, 2024
• Study Start: February 1, 2024
• Primary Completion: May 1, 2024
• Study Completion: June 1, 2024
• Last Updated: January 30, 2024

Record last verified: 2024-01