IDH1 and OCT4 in High Grade Astrocytoma
IDH1 and OCT4 Markers as a Prognostic Factor in Clinical Outcome of High Grade Astrocytic Glioma
1 other identifier
observational
35
1 country
1
Brief Summary
observation of IDH1 and OCT4 markers level and high grade astrocytoma patients prognosis after excision.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Sep 2024
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 10, 2024
CompletedFirst Posted
Study publicly available on registry
January 19, 2024
CompletedStudy Start
First participant enrolled
September 1, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2025
CompletedAugust 6, 2024
August 1, 2024
8 months
January 10, 2024
August 4, 2024
Conditions
Outcome Measures
Primary Outcomes (1)
IDH1 and OCT4 markers and their relation to postoperative prognosis of high grade astrocytoma patients
explore the relationship between prognosis (progression free and overall survival ) and biomarkers (IDH1 and OCT4 ) after excision of high grade astrocytoma
baseline
Interventions
IDH1 and OCT4 markers analysis of surgical specimens of high grade astrocytoma
Eligibility Criteria
patients with high grade astrocytic glioma , more than 18 years old and fit for surgery that will be admitted in the department of neurosurgery in Assiut university hospital
You may qualify if:
- patients of high grade astrocytic glioma patients fit for surgery
You may not qualify if:
- patients of low grade glioma patients unfit for surgery
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Faculty of Medicine of Assiut University
Asyut, 71525, Egypt
Related Publications (4)
PubMed
BACKGROUNDOstrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, Pekmezci M, Schwartzbaum JA, Turner MC, Walsh KM, Wrensch MR, Barnholtz-Sloan JS. The epidemiology of glioma in adults: a "state of the science" review. Neuro Oncol. 2014 Jul;16(7):896-913. doi: 10.1093/neuonc/nou087.
PMID: 24842956RESULTPerry A, Wesseling P. Histologic classification of gliomas. Handb Clin Neurol. 2016;134:71-95. doi: 10.1016/B978-0-12-802997-8.00005-0.
PMID: 26948349RESULTSathornsumetee S, Rich JN, Reardon DA. Diagnosis and treatment of high-grade astrocytoma. Neurol Clin. 2007 Nov;25(4):1111-39, x. doi: 10.1016/j.ncl.2007.07.004.
PMID: 17964028RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- OTHER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- doctor
Study Record Dates
First Submitted
January 10, 2024
First Posted
January 19, 2024
Study Start
September 1, 2024
Primary Completion
May 1, 2025
Study Completion
August 1, 2025
Last Updated
August 6, 2024
Record last verified: 2024-08