MIT Intensive Treatment Study

NCT06213376 | Completed

• 1 other identifier: 2312-0370
• Study Type: interventional
• Target: 1
• Locations: 1 country
• Sites: 1

Brief Summary

This study is examining the use of intensive melodic intonation therapy and video feedback as a means of aiding individuals with nonfluent aphasia and co-occurring motor speech impairments. Individuals with nonfluent aphasia have difficulty with language, particularly with word retrieval.

Conditions

Stroke; Aphasia; Motor Speech

Outcome Measures

Primary Outcomes (1)

• Intelligibility

  Intelligibility as measured by percentage of consonants correct and by targets produced on trained and untrained stimuli. 20 trained and 20 untrained speech phrases that are relevant to the client (measured during reading and repetition tasks)

  From enrollment to 4 weeks post treatment

Secondary Outcomes (4)

• Apraxia Battery for Adults

  Baseline and one week following the end of treatment

• Assessment of Intelligibility of Dysarthria Speech

  Baseline and one week following the end of treatment

• Longer Connected Speech Assessment

  Baseline and one and four weeks following the end of treatment

• Quality of Life with Dysarthria (QOLdys)

  Baseline and four weeks following treatments.

Study Arms (1)

Intervention

EXPERIMENTAL

20 sessions/4 weeks: Video Feedback: S1) Participant (P1) views recording of previous session with the clinician \& judges whether the production is intelligible. S2) S1 \& the clinician identifies changes in motor movements that are influencing performance. S3+S4) S1+S2 \& given support from the clinician, P1 identifies techniques improving intelligibility \& modifies behavior accordingly. MIT (Albert et al., 1973; Helm-Estabrooks et al., 2014): Humming - Clinician introduces the target phrase by showing a visual cue, humming the phrase, then intoning the phrase while P1 taps left-hand. Simultaneous production with melody - The Clinician and P1 melodically produce the target phrase \& tap together. Simultaneous melodic production accompanied by gradual reduction of clinician support. Immediate repetition response to probe question - Following P1's successful repetition, the clinician melodically produces a question and P1 melodically produces the target.

Behavioral: Melodic Intonation Therapy; Behavioral: Video Feedback Performance Review

Interventions

Melodic Intonation Therapy BEHAVIORAL

Melodic Intonation Therapy uses intonation and melody to aid individuals with aphasia with producing words.

Intervention

Video Feedback Performance Review BEHAVIORAL

Participant will view recording to judge correct and incorrect productions of trained words and to identify motor techniques increasing intelligibility

Intervention

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Fluent English speakers
• Sustained a left-hemisphere stroke
• Presents with language and motor speech impairments

You may not qualify if:

• History of learning disability prior to accident (per patient report)
• Uncorrected auditory or visual impairments
• Not meeting the criteria of stroke
• Failure to provide evidence of stroke diagnosis (medical record history)
• History of psychiatric disorder

Sponsors & Collaborators

• Nevada State University: lead

Study Sites (1)

Nevada State University

Henderson, Nevada, 89002, United States

Location

Related Publications (3)

• Albert ML, Sparks RW, Helm NA. Melodic intonation therapy for aphasia. Arch Neurol. 1973 Aug;29(2):130-1. doi: 10.1001/archneur.1973.00490260074018. No abstract available.

  PMID: 4717723 BACKGROUND

• Helm-Estabrooks, N., Albert, M. L., & Nicholas, M. (2014). Manual of aphasia and aphasia therapy (3rd ed.). Austin, TX: Pro-Ed

  BACKGROUND

• Zumbansen A, Peretz I, Hebert S. Melodic intonation therapy: back to basics for future research. Front Neurol. 2014 Jan 28;5:7. doi: 10.3389/fneur.2014.00007. eCollection 2014.

  PMID: 24478754 BACKGROUND

MeSH Terms

Conditions

Stroke; Aphasia

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Speech Disorders; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Andre Lindsey, PhD

  Nevada State University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: Independent Raters will be used to examine non-standardized outcomes at benchmark time points.
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor of Speech Pathology

Model Details: Single-subject experimental design

Study Record Dates

• First Submitted: January 9, 2024
• First Posted: January 19, 2024
• Study Start: December 28, 2023
• Primary Completion: February 23, 2024
• Study Completion: February 23, 2024
• Last Updated: August 30, 2024

Record last verified: 2024-08

Locations

US (1)