The Target Urine VOCs Biosensor for Genitourinary Malignancy Detection

NCT06211010 | Completed DMC

• 1 other identifier: EC-64-109
• Study Type: observational
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

Volatile organic compounds (VOCs) have grown due to their crucial role in transitioning from invasive to noninvasive cancer diagnostic methods. This study aimed to assess the feasibility of the metal oxide biosensor platform using urine VOCs for detecting genitourinary cancers. Five different commercially available semiconductor sensors were chosen to detect specific VOCs (methane, iso-butane, hydrogen, ethanol, hydrogen sulfide, ammonia, toluene, butane, propane, trimethylamine, and methyl-mercaptan). Changes in electrical resistance due to temperature variations from the voltage heater were examined to characterize VOC metabolism. Logistic regression and ROC analysis were employed to evaluate potential urine VOCs for genitourinary cancer determination.

Conditions

The Phenomenon of the Decrease in the Electrical Resistance Within the Conducting Chambers, Making the Increase in a Conducting Property

Keywords

Volatile Organic Compounds (VOCs); Biosensor; Genitourinary Cancer

Outcome Measures

Primary Outcomes (1)

• the Target Urine Volatile Organic Compounds from urinary cancers

  urine VOCs for detecting genitourinary cancers

  DEC 2021-SEP 2023

Interventions

the semiconductor metal oxide sensors. DIAGNOSTIC_TEST

The method of analyzing the VOCs was through analyzing the evaporated VOCs from the urine in the container when they evaporated into the sealed chamber. The VOCs in the chamber were then analyzed at the same time by the five different gas semiconductor sensors which were located on the top of the chamber.

Also known as: The detailed products and basic semiconductor circuits are available in the Figaro Product Information Manual (https://www.figarosensor.com/product/sensor/).

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

pateints at Nephrology and Urology clinic of Suranaree University of Technology

You may qualify if:

• Age \> 16 years

You may not qualify if:

• The patients with the renal diseases and the normal subjects were prohibited to have strong odor food

Sponsors & Collaborators

• Suranaree University of Technology: lead

Study Sites (1)

Institute of Medicine, Suranaree University of Technology

Nakhon Ratchasima, 30000, Thailand

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Fresh Urine sample 20 mL for a pateint

MeSH Terms

Conditions

Urogenital Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• Chatchai Kreepala, M.D.

  School of Internal Medicine, Institute of Medicine, Suranaree University of Technology, Thailand

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 2 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor Dr. Chatchai Kreepala, M.D.

Study Record Dates

• First Submitted: January 8, 2024
• First Posted: January 18, 2024
• Study Start: December 1, 2021
• Primary Completion: September 1, 2023
• Study Completion: November 1, 2023
• Last Updated: January 18, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will not share

Locations

TH (1)