Evaluation of Herpes Zoster Characteristics and Costs in Cancer Population.

NCT06207487 | Unknown

• 1 other identifier: 3527/23
• Study Type: observational
• Target: 150
• Locations: 0 countries
• Sites: N/A

Brief Summary

Rationale. Cancer patients are more likely to develop herpes zoster (HZ) and its complications. An acute episode of HZ implies in postponement of current cancer treatments, hospitalization, high risk of development of postherpetic neuralgia and high costs for paying sources. A better understanding of disease incidence, hospitalization, development of postherpetic neuralgia, and costs generated for funding sources may increase awareness of the impact of vaccination on oncology population. Objectives. Obtain HZ incidence and percentage of hospitalization in study population according to cancer type, topography, and stage. Estimate hospital costs arising from hospitalizations for different paying sources: National Public Health System (SUS - Unified Health System), health operators and private source (patient). Methods. We propose a retrospective descriptive study of HZ episodes occurred in oncological population attended at AC Camargo Cancer Center between 2019 September and 2022 August.

Conditions

Herpes Zoster

Keywords

herpes zoster; cancer; costs; postherpetic neuralgia

Outcome Measures

Primary Outcomes (1)

• Occurence

  Profile the occurrence of HZ in oncological population treated in a Brazilian cancer center.

  Between 2019 september at 2 years.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult cancer population (solid tumor or hematologic malignancies) from Ac Camargo Cancer Center, São Paulo - Brazil.

You may qualify if:

• Admission at AC Camargo Cancer Center between 2019 september and 2022 august at emergency department and/or inpatient ward, including intensive care unit
• Acute episode of Herpes Zoster or recurrence (see item 5.1. for ICD-10 codes).
• Acute episode of HZ is clinically defined as painful, polymorphic, acute cutaneous lesions composed of macules, papules, vesicles and crusts at different stages of development, affecting delimited dermatomes or disseminated (when it affects two or more dermatomes).
• Recurrence of HZ is defined as any occurrence of HZ that happens after the initial episode.
• Active cancer is defined as: diagnosis of local, regionally advanced or metastatic cancer; treatment naïve, receiving oncological therapies or palliative care in the last year.

You may not qualify if:

• Age under 18 years
• Absence of evidence of oncological disease: cases classified as complete remission or without evidence of oncological disease (not receiving any kind of oncological treatment for at least one year)

Sponsors & Collaborators

• AC Camargo Cancer Center: lead

MeSH Terms

Conditions

Herpes Zoster; Neoplasms; Neuralgia, Postherpetic

Condition Hierarchy (Ancestors)

Varicella Zoster Virus Infection; Herpesviridae Infections; DNA Virus Infections; Virus Diseases; Infections; Neuralgia; Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Anna P Romero de Oliveira, physician

CONTACT

5511982317986; anna.oliveira@accamargo.org.br

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 5, 2024
• First Posted: January 17, 2024
• Study Start: February 15, 2024
• Primary Completion: February 29, 2024
• Study Completion: December 30, 2024
• Last Updated: January 17, 2024

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will not share