Optimisation of Eccentric Exercises

NCT06193824 | Unknown

• 1 other identifier: RBHP 2022 RANNOU
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Regular physical activity is an important public health lever and is recognised as an alternative in the management of certain long-term conditions. To achieve beneficial effects on the body, exercise recommendations are based on several parameters such as duration, intensity and continuous or intermittent nature of the activity. However, the mode of muscle contraction during exercise is generally little considered or poorly defined in these recommendations, which can lead to prescribing errors. In particular, the eccentric contraction modality, which can be found in actions designed to slow down movement (e.g. walking downhill), represents an interesting strategy, but its prescription modalities are still poorly understood. The beneficial effects of physical activity are based in part on the release of molecules (myokines) by the skeletal muscles during exercise, which improve the functioning of the body. However, the effect of downhill walking on the release of myokines by the muscle has been little studied. The lack of knowledge of this effect is therefore an obstacle to the use of this exercise modality to try to optimise physical activity recommendations for health or performance improvement. The aim of this study is therefore to better understand how downhill walking (eccentric muscle contraction) affects the production of molecules by muscles (myokines) during exercise.

Conditions

Healthy Control Subjects

Outcome Measures

Primary Outcomes (2)

• Effect of eccentric exercise on myokine concentrations

  Changes in systemic myokine levels following submaximal downhill treadmill exercise at different inclines, at the same speed and for the same duration.

  Blood sample at baseline (prior exercise), Hour 1 and Hour 24 post-exercise

• Effect of treadmill inclination on myokine concentrations

  Differences in systemic myokine levels concentrations following -10 and -20% gradient submaximal downhill treadmill exercises, at the same speed and for the same duration.

  Blood sample at baseline (prior exercise), Hour 1 and Hour 24 post-exercise

Secondary Outcomes (6)

• Assessment of exercise-induced muscle fatigue in lower limbs

  Baseline (prior exercise) and 15 seconds post-exercise

• Assessment of exercise-induced muscle fatigue in lower limbs

  Baseline (prior exercise) and 15 seconds post-exercise

• Assessment of autonomic nervous system function

  During treadmill exercise

• Effect of treadmill exercise on muscle volume

  Baseline (prior exercise) and 15 seconds post-exercise

• Effect of treadmill exercise on muscle pain

  Baseline (prior exercise) and 15 seconds post-exercise

Study Arms (2)

downhill treadmill walking -10% gradient

EXPERIMENTAL

The subjects will perform downhill walking at 6 km/h for 45 min on a treadmill (-10% incline)

Device: Experimental: downhill treadmill walking at -10% and -20% gradient

downhill treadmill walking -20% gradient

EXPERIMENTAL

The subjects will perform downhill walking at 6 km/h for 45 min on a treadmill (-20% incline)

Device: Experimental: downhill treadmill walking at -10% and -20% gradient

Interventions

Experimental: downhill treadmill walking at -10% and -20% gradient DEVICE

The subjects will perform downhill walking at 6 km/h for 45 min on a treadmill (-10% or -20% incline)

downhill treadmill walking -10% gradient; downhill treadmill walking -20% gradient

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Body Mass Index between 18.5 and 24.9 kg/m² (18.5 ≤ BMI ≤ 24.9)
• Non-smoker
• No treatment (background or at the time of the examination)
• Physical check up considered compatible with study participation (no bones, articular or muscular problems in lower limbs)
• Subjects considered healthy by investigator based on medical questioning and clinical examination
• Affiliation to the French Social Security system
• Person who has read and understood the research-related information, and signed the consent forms

You may not qualify if:

• Smoking
• Subjects with heart or respiratory failure
• Participants with lower extremity injury in the past three months
• Contraindication to the application of a magnetic field (wearing a pacemaker, presence of prosthetic material or ferromagnetic foreign bodies, presence of cochlear implants or ocular prosthetic material)
• Participant that does not wish to participate (refusal to sign the consent form)
• Patients under guardianship, trusteeship, deprived of liberty or safeguard of justice

Sponsors & Collaborators

• University Hospital, Clermont-Ferrand: lead

Study Sites (1)

Chu Clermont Ferrand

Clermont-Ferrand, France

RECRUITING

Central Study Contacts

Lise Laclautre

CONTACT

334.73.754.963; promo_interne_drci@chu-clermontferrand.fr

Fabrice Rannou

CONTACT

fabrice.rannou@uca.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Crossover Assignment

Study Record Dates

• First Submitted: June 23, 2023
• First Posted: January 5, 2024
• Study Start: May 4, 2023
• Primary Completion: June 1, 2024
• Study Completion: December 1, 2024
• Last Updated: January 11, 2024

Record last verified: 2023-05

Locations

FR (1)