Changes in Cardiac Functions in Patients Treated With Parathyroidectomy for Secondary Hyperparathyroidism

NCT06187480 | Completed

• 1 other identifier: E-78017789-050.01.04-1638902
• Study Type: observational
• Target: 37
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate the changes in cardiac functions, especially myocardial performance index (MPI), in patients who underwent parathyroidectomy for secondary hyperparathyroidism. Participants who underwent parathyroidectomy for secondary hyperparathyroidism between June 2010 and September 2021 were analyzed retrospectively. The participants were divided into two groups: those who underwent total parathyroidectomy (group 1) and those who underwent subtotal parathyroidectomy (group 2). The groups were compared according to the echocardiogram findings performed in the preoperative period and the postoperative sixth month. In addition, cardiac structure, systolic and diastolic function, especially myocardial performance index, were evaluated by echocardiography and Doppler imaging.

Conditions

Secondary Hyperparathyroidism; Myocardial Dysfunction

Keywords

Secondary hyperparathyroidism; myocardial performance index

Outcome Measures

Primary Outcomes (1)

• Comparison of myocardial performance indexes between groups

  Evaluation of patients' myocardial performance indexes between groups using echocardiography and Doppler imaging in the preoperative period and at the 6th postoperative month.

  preoperatively and postoperative 6th month

Study Arms (2)

group 1

underwent total parathyroidectomy

Procedure: total parathyroidectomy (group 1) and those who underwent subtotal parathyroidectomy (group 2)

group 2

underwent subtotal parathyroidectomy

Procedure: total parathyroidectomy (group 1) and those who underwent subtotal parathyroidectomy (group 2)

Interventions

total parathyroidectomy (group 1) and those who underwent subtotal parathyroidectomy (group 2) PROCEDURE

The groups were compared according to the echocardiogram findings performed in the preoperative period and the postoperative sixth month. In addition, cardiac structure, systolic and diastolic function, especially myocardial performance index, were evaluated by echocardiography and Doppler imaging.

group 1; group 2

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The patients who developed secondary hyperparathyroidism after chronic renal failure and underwent subtotal/total parathyroidectomy in our hospital between June 2010 and September 2021 were analyzed with a single-center Nested case-control study design.

You may qualify if:

• Patients with a diagnosis of chronic renal failure, secondary hyperthyroidism after chronic renal failure, preoperative and postoperative laboratory tests, parathyroidectomy operation, and preoperative and postoperative 6-month transthoracic echocardiography (ECHO) were included in the study.

You may not qualify if:

• Advanced-stage lung disease, atrial fibrillation, atrial and supraventricular tachycardia, extra ventricular beats, intraventricular conduction disorders, ventricular pacing, moderate to severe valve pathology, history of bypass surgery, poor image quality in transthoracic echocardiography as cardiac comorbidities Patients with disease and missing data were excluded from the study.

Sponsors & Collaborators

• Mersin University: lead

Study Sites (1)

Mersin University Faculty of Medicine

Mersin, 33400, Turkey (Türkiye)

Location

Related Publications (1)

• Benli S, Yesil E, Tazeoglu D, Ozcan C, Ozcan IT, Dag A. Changes in cardiac functions in patients treated with parathyroidectomy for secondary hyperparathyroidism. Updates Surg. 2024 Aug;76(4):1443-1452. doi: 10.1007/s13304-024-01812-8. Epub 2024 Mar 26.

  PMID: 38530609 DERIVED

MeSH Terms

Conditions

Hyperparathyroidism, Secondary

Condition Hierarchy (Ancestors)

Hyperparathyroidism; Parathyroid Diseases; Endocrine System Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor

Study Record Dates

• First Submitted: December 2, 2023
• First Posted: January 2, 2024
• Study Start: January 1, 2021
• Primary Completion: December 31, 2022
• Study Completion: January 1, 2023
• Last Updated: January 3, 2024

Record last verified: 2023-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)