NCT06179212|Recruiting
Exercise Testing Protocols for Females and Males With CAD
PACED
Comparing VO2 Peak Values of Exercise Testing Protocols for Females and Males With CAD
Loading search results
PACED
Comparing VO2 Peak Values of Exercise Testing Protocols for Females and Males With CAD
Sponsor study identifier
observational
54
1 country
1
Study Start
March 1, 2024
Actual (reported)Primary Completion
December 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The aim of this study is to determine if the test that allows males to achieve a higher VO2 (a measure of oxygen use during exercise) is different for females. The purpose of this study is to test 4 different exercise testing protocols to compare measured oxygen consumption in females and males with CAD (disease caused by the buildup of plaque in the artery walls which can lead to insufficient amounts of blood, nutrients and oxygen being supplied to the heart). The 4 exercise tests that will be completed on the treadmill are the modified Balke, modified Bruce, modified Naughton and University of Ottawa Heart Institute Slow Ramp protocols. Each test has a different stage duration (the amount of time that the test remains at a pre-determined speed and incline), and incremental increase in speed and incline. The main purpose of this study is to compare VO2 peak (the maximal amount of oxygen utilized during the exercise test) of females and males with CAD in 4 different exercise protocols. For example, the investigators will find out:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 11, 2023
Actual (reported)December 21, 2023
Actual (reported)March 1, 2024
Actual (reported)December 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
December 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Oxygen Consumption (VO2)
V̇O2 will be measured continuously throughout the treadmill CPET. Peak V̇O2, defined as the highest V̇O2 value that is achieved over a 20-s period during the last minute of the CPET. V̇O2 will be measured throughout each test by a metabolic system (Parvo Medics TrueOne 2400).
Week 1 to week 4 (measured weekly, at every appointment)
Cardiometabolic health indicators - Blood pressure (BP)
Week 1 to week 4 (measured weekly, at every appointment)
Cardiometabolic health indicators - Heart Rate (HR)
Week 1 to week 4 (measured weekly, at every appointment)
Cardiometabolic health indicators - Body mass index
Week 1 to week 4 (measured weekly, at every appointment)
Cardiometabolic health indicators - Fat mass
Week 1 to week 4 (measured weekly, at every appointment)
Cardiometabolic health indicators - Waist circumference
Week 1 to week 4 (measured weekly, at every appointment)
Patients will perform all 4 maximal cardiopulmonary exercise tests in randomized order. The protocols they will perform are: Modified Bruce, modified Naughton, modified Balke and the UOHI Slow Ramp.
Patients will complete 4 different cardiopulmonary exercise tests in random order.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Adults older than 18 years of age and have been diagnosed with CAD.
University of Ottawa Heart Institute
Ottawa, Ontario, K1Y 4W7, Canada
Jennifer Reed, PhD
Ottawa Heart Institute Research Corporation
First Submitted
December 11, 2023
First Posted
December 21, 2023
Study Start
March 1, 2024
Actual (reported)Primary Completion
December 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Contact the study team to confirm eligibility.
Study Completion
December 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 5, 2026
Record last verified: 2026-09
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: