Magnetic Resonance Neurography Analysis of Healthy Human Thoracic Dorsal Root Ganglion

NCT06177379 | Completed

• 1 other identifier: dorsal root ganglion
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

Here, this study aimed to conduct magnetic resonance neurography (MRN) of the thoracic DRGs in a cohort of healthy individuals. The acquired images will be thoroughly analyzed utilizing 3D-slicer software. We expect to furnish crucial baseline anatomical data of thoracic DRGs in healthy subjects, provide an anatomical basis for clinical investigation and therapeutic interventions.

Conditions

Dorsal Root Ganglion

Keywords

dorsal root ganglion,; Magnetic resonance neurography; volume; neuropathic pain

Outcome Measures

Primary Outcomes (1)

• the average DRG volume of healthy volunteers

  the average DRG volume in each thoracic segment of healthy volunteers

  202301-202312

Secondary Outcomes (1)

• width/length ratio of DRGs

  202301-202312

Interventions

healthy volunteer OTHER

Volunteers age between 50 and 75 years

Eligibility Criteria

• Age: 40 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

healthy volunteers aged between 50 and 75 years, height between 145cm to 180cm, and BMI between 18.5 to 30.

You may qualify if:

• age between 40 and 75 years;
• height between 145cm to 180cm;
• BMI between 18.5 to 30.

You may not qualify if:

• scoliosis;
• history of thoracic surgery and pain;
• history of spinal trauma and surgery;
• failure or inability to complete magnetic resonance neurography (MRN) scans.

Sponsors & Collaborators

• Huazhong University of Science and Technology: lead

Study Sites (1)

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, China

Location

Related Publications (6)

• Attal N, Bouhassira D. Advances in the treatment of neuropathic pain. Curr Opin Neurol. 2021 Oct 1;34(5):631-637. doi: 10.1097/WCO.0000000000000980.

  PMID: 34310363 BACKGROUND

• Berger AA, Liu Y, Possoit H, Rogers AC, Moore W, Gress K, Cornett EM, Kaye AD, Imani F, Sadegi K, Varrassi G, Viswanath O, Urits I. Dorsal Root Ganglion (DRG) and Chronic Pain. Anesth Pain Med. 2021 Mar 28;11(2):e113020. doi: 10.5812/aapm.113020. eCollection 2021 Apr.

  PMID: 34336621 BACKGROUND

• Malik KM, Imani F, Beckerly R, Chovatiya R. Risk of Opioid Use Disorder from Exposure to Opioids in the Perioperative Period: A Systematic Review. Anesth Pain Med. 2020 Feb 19;10(1):e101339. doi: 10.5812/aapm.101339. eCollection 2020 Feb.

  PMID: 32337175 BACKGROUND

• Attal N, Bouhassira D, Baron R. Diagnosis and assessment of neuropathic pain through questionnaires. Lancet Neurol. 2018 May;17(5):456-466. doi: 10.1016/S1474-4422(18)30071-1. Epub 2018 Mar 26.

  PMID: 29598922 BACKGROUND

• Liem L, van Dongen E, Huygen FJ, Staats P, Kramer J. The Dorsal Root Ganglion as a Therapeutic Target for Chronic Pain. Reg Anesth Pain Med. 2016 Jul-Aug;41(4):511-9. doi: 10.1097/AAP.0000000000000408.

  PMID: 27224659 BACKGROUND

• Bannister K, Sachau J, Baron R, Dickenson AH. Neuropathic Pain: Mechanism-Based Therapeutics. Annu Rev Pharmacol Toxicol. 2020 Jan 6;60:257-274. doi: 10.1146/annurev-pharmtox-010818-021524.

  PMID: 31914896 BACKGROUND

MeSH Terms

Conditions

Neuralgia

Condition Hierarchy (Ancestors)

Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Xianwei Zhang, Doctor

  Huazhong University of Science and Technology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Professor

Study Record Dates

• First Submitted: December 11, 2023
• First Posted: December 20, 2023
• Study Start: January 1, 2023
• Primary Completion: August 31, 2023
• Study Completion: December 10, 2023
• Last Updated: December 20, 2023

Record last verified: 2023-12

Locations

CN (1)