Analysis of the Causes of Redo Pull-through for Recurrent Constipation and the Risk Factors Affecting the Prognosis of the Hirschsprung's Disease and Allied Disorders

NCT06175598 | Completed

• 1 other identifier: TJ-IRB20230739
• Study Type: observational
• Target: 79
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to conducted a comprehensive analysis of the factors contributing to redo- Pull-through surgery for constipation recurrence in Children who are suffering from Hirschsprun' s disease (HSCR) and its allied disorders (ADHD) . The main question\[s\] it aims to answer are:

1. 1.Our study focused on the treatment and prognosis of these conditions, drawing upon 16 years of patient data and clinical experiences"
2. 2.What are the key risk factors affecting the prognosis of recurrent constipation patients undergoing repeat PT?

Conditions

Surgery; Pediatric ALL

Outcome Measures

Primary Outcomes (2)

• Participants with redo-pull-through surgery for recurrent constipation

  After utilizing the terms "Hirschsprung" and "Redo pull-through" in searches across "PubMed" and "Web of Science" for references published between 1990 and 2023, and subsequent removal of duplicate and incomplete documents, we compiled clinical information from the remaining literature. This compilation facilitated a review of relevant literature on the causes of redo-PT for recurrent constipation, enabling an assessment of classification types, which we categorized into five groups: Incomplete Resection of Affected Intestinal Segments (IRAIS), Acquire Aganglionosis (AA), Intestinal Dysmotility (ID), Anastomotic Complications (AC), and Intestinal Neurodevelopmental Impairment (INI).

  1990-2023

• Participants with and without postoperative complications

  Group the data by gender, age groups, surgical techniques, and surgical approaches. Then, calculate the number of cases with and without postoperative complications

  through study completion, an average of 33 year

Study Arms (5)

Acquire Aganglionosis (AA)

Intestinal Dysmotility (ID)

Anastomotic Complications (AC)

Intestinal Neurodevelopmental Impairment (INI)

Incomplete Resection of Affected Intestinal Segments (IRAIS)

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study collected comprehensive clinical data and compiled postoperative follow-up data from patients who underwent corrective surgery for HSCR and ADHD and subsequently required redo-PT due to recurrent constipation.

You may qualify if:

• Patients admitted to the department of pediatric surgery at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, between January 2005 and December 2021;
• HSCR and ADHD patients admitted due to "constipation recurrence" and requiring redo-PT.

You may not qualify if:

• Patients undergoing staged surgeries or undergoing internal sphincterotomy;
• Patients with concomitant severe congenital anomalies such as Down syndrome; (3) Patients with incomplete postoperative follow-up data after redo-PT.

Sponsors & Collaborators

• Feng Jiexiong: lead

Study Sites (1)

Department of Pediatric Surgery

Wuhan, Hubei, 430000, China

Location

MeSH Terms

Conditions

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Condition Hierarchy (Ancestors)

Leukemia, Lymphoid; Leukemia; Neoplasms by Histologic Type; Neoplasms; Hematologic Diseases; Hemic and Lymphatic Diseases; Lymphoproliferative Disorders; Lymphatic Diseases; Immunoproliferative Disorders; Immune System Diseases

Study Officials

• Jiexiong Feng, PhD

  Tongji Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: December 7, 2023
• First Posted: December 19, 2023
• Study Start: December 1, 2023
• Primary Completion: December 7, 2023
• Study Completion: December 7, 2023
• Last Updated: December 27, 2023

Record last verified: 2023-12

Locations

CN (1)