US-guided Pericapsular Nerve Group (PENG) Block in Different Volumes on Postoperative Pain in Hip Replacement Surgeries

NCT06166602 | Completed

• 1 other identifier: 2023/0455
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Postoperative pain management has an important place in anesthesia practices. In order to ensure patient comfort after the surgery, to start postoperative rehabilitation early, and to prevent the process from causing mood disorders such as anxiety and pathological conditions such as chronic pain syndrome, the pain caused by the operation in the postoperative period must be effectively relieved. Pericapsular nerve group (PENG) block; It is a regional anesthesia technique that targets the anterior capsule of the hip joint and aims to block the joint branches of the accessory obturator nerve and femoral nerve by administering local anesthetic. Although it has been described recently, controlled prospective studies in the literature have shown it to be a safe and effective regional technique for postoperative pain after hip surgery. However, volume studies on this block are limited. Therefore, in this study, we aimed to determine the optimal dose by comparing the effectiveness of PENG block on pain using different local anesthetic volumes.

Conditions

Regional Anesthesia; Postoperative Pain; Hip Surgery

Keywords

Regional Anesthesia

Outcome Measures

Primary Outcomes (1)

• Numeric Rating Scale Score

  Numeric Rating Scale Score (0: No pain, 10: Worst pain imaginable)

  Up to 24 hours

Secondary Outcomes (3)

• Postoperative Opioid Consumption

  Up to 24 hours

• Postoperative Nausea and Vomiting

  Up to 24 hours

• Patient satisfaction

  Up to 24 hours

Study Arms (2)

Group 1

ACTIVE COMPARATOR

PENG block was planned to be applied to group 1 patients with 20 cc of 0.25% bupivacaine.

Drug: PENG block with 0.25% bupivacaine.

Group 2

ACTIVE COMPARATOR

PENG block was planned to be applied to group 2 patients with 10 cc of 0.25% bupivacaine.

Drug: PENG block with 0.25% bupivacaine.

Interventions

PENG block with 0.25% bupivacaine. DRUG

Peng block will be applied to the same side as the surgery, using 0.25% bupivacaine at the same concentration in different volumes.

Also known as: Marcain®

Group 1; Group 2

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with informed consent
• Patients planned for hip surgery
• Those between the ages of 18-80
• ASA (American Society of Anesthesiologists) I-III patients

You may not qualify if:

• Patients who do not give consent
• Patients with coagulopathy
• Patients with a history of local anesthetic drug allergy and toxicity
• Patients with advanced organ failure
• Patients with mental retardation
• Patients with infection at the injection site
• Pediatric patients and patients over 80 years of age
• Pregnant patients will not be included in the study.

Sponsors & Collaborators

• Istanbul Medeniyet University: lead

Study Sites (1)

Istanbul Medeniyet University

Istanbul, Turkey (Türkiye)

Location

Related Publications (3)

• Pascarella G, Costa F, Del Buono R, Pulitano R, Strumia A, Piliego C, De Quattro E, Cataldo R, Agro FE, Carassiti M; collaborators. Impact of the pericapsular nerve group (PENG) block on postoperative analgesia and functional recovery following total hip arthroplasty: a randomised, observer-masked, controlled trial. Anaesthesia. 2021 Nov;76(11):1492-1498. doi: 10.1111/anae.15536. Epub 2021 Jul 1.

  PMID: 34196965 BACKGROUND

• Choi YS, Park KK, Lee B, Nam WS, Kim DH. Pericapsular Nerve Group (PENG) Block versus Supra-Inguinal Fascia Iliaca Compartment Block for Total Hip Arthroplasty: A Randomized Clinical Trial. J Pers Med. 2022 Mar 6;12(3):408. doi: 10.3390/jpm12030408.

  PMID: 35330408 BACKGROUND

• Lin DY, Brown B, Morrison C, Fraser NS, Chooi CSL, Cehic MG, McLeod DH, Henningsen MD, Sladojevic N, Kroon HM, Jaarsma RL. The Pericapsular Nerve Group (PENG) block combined with Local Infiltration Analgesia (LIA) compared to placebo and LIA in hip arthroplasty surgery: a multi-center double-blinded randomized-controlled trial. BMC Anesthesiol. 2022 Aug 6;22(1):252. doi: 10.1186/s12871-022-01787-2.

  PMID: 35933328 BACKGROUND

MeSH Terms

Conditions

Pain, Postoperative

Interventions

Bupivacaine

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Anilides; Amides; Organic Chemicals; Aniline Compounds; Amines

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Masking Details: The investigator is not masked as different volumes are applied.
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: December 4, 2023
• First Posted: December 12, 2023
• Study Start: June 20, 2023
• Primary Completion: December 20, 2023
• Study Completion: December 22, 2023
• Last Updated: February 2, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)