The Effects of a 12-week Combined Exercise Intervention on the Gut Microbiome of Older Adults

NCT06153719 | Unknown

• 1 other identifier: 1772160
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

There are trillions of microorganisms living alongside us in our guts. Recent research has shown that this community, known as the gut microbiome, has a big influence on our health and wellbeing. Imbalances in the composition of the gut microbial community has been linked to several diseases including COVID, mental ill health, and diabetes. When the composition of the gut microbiome changes towards a less healthy one (called dysbiosis) this will, in turn, affect our health in a negative way. The composition of our gut microbiome remains fairly stable during adulthood, however, as we move into older age, there is a shift and its composition will change to a less healthy one; this is one of the reasons why older people can be more susceptible to diseases. Fortunately, there are several tools that we can use to improve our gut microbiome and one of them is exercise. Besides its well-known effects on our health, exercise has been shown to be able to improve the gut microbiome composition of younger people and those with certain metabolic diseases such as obesity. However, less is known about the effects of exercise on the gut microbiome of older adults. The aim of this study, therefore, is to assess the effects of a 12-week exercise intervention on the gut microbiome of physically inactive older adults. Hopefully, after this study, the investigators will have more information on whether exercise can be used as a tool to improve the gut microbiome of older adults therefore improving their overall health and quality of life.

Conditions

Physical Inactivity

Keywords

Gut microbiome; Exercise; Physical activity; Physical inactivity; Older adults; Gut microbiota

Outcome Measures

Primary Outcomes (1)

• Gut microbiome composition

  Gut microbiome composition will be analysed using 16s rRNA sequencing

  At the begining and at the end of the intervention

Study Arms (2)

Exercise group

ACTIVE COMPARATOR

Other: 12-weeks combined exercise intervention

Control group

PLACEBO COMPARATOR

Other: 12-weeks combined exercise intervention

Interventions

12-weeks combined exercise intervention OTHER

This 12-week combined exercise intervention will consist of 3 supervised exercise classes per week, each one lasting 50 minutes. It will involve both aerobic and resistance training in order to follow the UK's physical activity recommendations

Control group; Exercise group

Eligibility Criteria

• Age: 65 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• Aged between 65-85 years old
• Healthy, free-living individuals
• Vaccinated against COVID-19
• Physically inactive (\<150 mins/week of PA)
• No participation in any exercise intervention studies in the last 3 months
• BMI Between 20-35 kg/m2

You may not qualify if:

• The use of antibiotics 3 months before or during the study
• Cancer
• Intestinal inflammatory conditions (e.g., Crohns, ulcerative colitis)
• Consumption of proton pump inhibitors (e.g., omeprazole, lansoprazole, etc…)
• Auto-immune diseases
• GI diseases (e.g., IBS, peptic ulcers)
• Routine consumption of pre and/or probiotic foods or supplements
• On blood thinners

Sponsors & Collaborators

• Nottingham Trent University: lead
• University of Reading: collaborator

Study Sites (1)

Nottingham Trent University - Clifton campus

Nottingham, United Kingdom

RECRUITING

Related Publications (6)

• Ramos C, Gibson GR, Walton GE, Magistro D, Kinnear W, Hunter K. Systematic Review of the Effects of Exercise and Physical Activity on the Gut Microbiome of Older Adults. Nutrients. 2022 Feb 5;14(3):674. doi: 10.3390/nu14030674.

  PMID: 35277033 BACKGROUND

• Taniguchi H, Tanisawa K, Sun X, Kubo T, Hoshino Y, Hosokawa M, Takeyama H, Higuchi M. Effects of short-term endurance exercise on gut microbiota in elderly men. Physiol Rep. 2018 Dec;6(23):e13935. doi: 10.14814/phy2.13935.

  PMID: 30536648 BACKGROUND

• Erlandson KM, Liu J, Johnson R, Dillon S, Jankowski CM, Kroehl M, Robertson CE, Frank DN, Tuncil Y, Higgins J, Hamaker B, Wilson CC. An exercise intervention alters stool microbiota and metabolites among older, sedentary adults. Ther Adv Infect Dis. 2021 Jun 25;8:20499361211027067. doi: 10.1177/20499361211027067. eCollection 2021 Jan-Dec.

  PMID: 34262758 BACKGROUND

• Barton W, Penney NC, Cronin O, Garcia-Perez I, Molloy MG, Holmes E, Shanahan F, Cotter PD, O'Sullivan O. The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level. Gut. 2018 Apr;67(4):625-633. doi: 10.1136/gutjnl-2016-313627. Epub 2017 Mar 30.

  PMID: 28360096 BACKGROUND

• Bressa C, Bailen-Andrino M, Perez-Santiago J, Gonzalez-Soltero R, Perez M, Montalvo-Lominchar MG, Mate-Munoz JL, Dominguez R, Moreno D, Larrosa M. Differences in gut microbiota profile between women with active lifestyle and sedentary women. PLoS One. 2017 Feb 10;12(2):e0171352. doi: 10.1371/journal.pone.0171352. eCollection 2017.

  PMID: 28187199 BACKGROUND

• Allen JM, Mailing LJ, Niemiro GM, Moore R, Cook MD, White BA, Holscher HD, Woods JA. Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans. Med Sci Sports Exerc. 2018 Apr;50(4):747-757. doi: 10.1249/MSS.0000000000001495.

  PMID: 29166320 BACKGROUND

MeSH Terms

Conditions

Sedentary Behavior; Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Kirsty Hunter

  Nottingham Trent University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Kirsty Hunter

CONTACT

+44 (0)115 848 3069; kirsty.hunter@ntu.ac.uk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Academic Associate

Study Record Dates

• First Submitted: November 22, 2023
• First Posted: December 1, 2023
• Study Start: December 1, 2023
• Primary Completion: June 1, 2024
• Study Completion: June 1, 2024
• Last Updated: December 8, 2023

Record last verified: 2023-12

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)