Virtual Reality Based Mirror Therapy
A New Perspective on Mirror Therapy: The Effect of Leap Motion-Based Multi-Axis Immersive Virtual Reality Mirror Therapy (LISA) on Upper Extremity Functions in Individuals With Stroke
1 other identifier
interventional
56
1 country
1
Brief Summary
The aim of this study is to examine the effectiveness of 3D virtual reality assisted mirror therapy based rehabilitation applications compared to classical methods used in stroke rehabilitation.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable stroke
Started Apr 2024
Typical duration for not_applicable stroke
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 22, 2023
CompletedFirst Posted
Study publicly available on registry
November 30, 2023
CompletedStudy Start
First participant enrolled
April 1, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 15, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
June 15, 2026
June 22, 2025
June 1, 2025
2.1 years
November 22, 2023
June 19, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Fugl-Meyer Assessment
It is a scale based on measuring upper extremity performance in stroke patients. Test; reflex activity, flexor and extensor synergy, combined synergistic movements, non-synergy movements, normal reflex activity, wrist and hand evaluation, coordination and speed evaluation subsections. It consists of 33 items in total, and each item is scored between 0 and 2 points (0: unable, 1: partially able, 2: fully able). The total score is 66.
8 Weeks
Secondary Outcomes (5)
Evaluation of Cortical Activation with EEG
8 Weeks
Motor Activity Log-28
8 Weeks
Simulator Sickness Questionnaire
8 Weeks
System Usability Scale
8 Weeks
Stroke-Specific Quality of Life Scale
8 Weeks
Study Arms (2)
VR group
ACTIVE COMPARATORDuring the exercise, games will be selected from the movements that focus on upper extremity function and require the use of both extremities. These functions will be to grasp the object with both hands, to throw the object, and to provide the object's rotation by revealing the hand's supination-pronation movement. During these movements, the image of the healthy side will be mirrored to the affected side. Before each exercise, what kind of movement requested from the patient will be shown in the VR environment.
Control group
ACTIVE COMPARATORIn addition to mirror therapy, Bobath therapy, walking exercises, upper extremity active exercises, proprioceptive neuromuscular facilitation techniques, which are traditional physical therapy and rehabilitation methods, will be applied to the control group. In addition, a virtual environment monitoring session will be conducted in non-interactive virtual environments for 10 minutes after their treatment.
Interventions
Mirror therapy-based games will be played for 30 minutes every day for eight weeks, three days a week, for the VR group.
Bobath therapy, walking exercises, upper extremity active exercises, and proprioceptive neuromuscular facilitation techniques will be applied three days a week for eight weeks.
In conventional mirror therapy, the unaffected extremities of the individuals will be positioned outside the mirror, while the affected extremities will be placed inside the mirror so that the patient cannot see them. In this way, the image of the intact hand will be transferred to the affected side and activities will be performed three days a week for eight weeks.
For 8 weeks, watching the uninteractive virtual environment for 10 minutes
Eligibility Criteria
You may qualify if:
- Have a ischemic stroke
- Stroke duration not less than 2 months and not more than 6 months
- Individuals with a score of 2b and 3 according to the Thrombolysis in cerebral infarction (TICI) scale
- A score of 2 and above according to the upper extremity motor assessment of the NIH stroke scale
- Intact depth perception in the Titmus Stereopsis assessment
- A score of 24 and above in the Mini-mental test and
- Independent sitting balance
You may not qualify if:
- Additional neurologic diseases
- Have a head injury
- Have a brain tumor
- Prior cranial surgery
- Psychological disorder or mental problem
- Previous stroke
- Aphasia and apraxia
- Upper extremity amputation
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Abant Izzet Baysal University Faculty of Health Science
Bolu, Merkez, 14100, Turkey (Türkiye)
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Ramazan Kurul, Ph.D
Abant Izzet Baysal University
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Masking Details
- The assessor will not know which group the patients are in. Participants in control group will experience a virtual reality environment without any interaction
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
November 22, 2023
First Posted
November 30, 2023
Study Start
April 1, 2024
Primary Completion (Estimated)
May 15, 2026
Study Completion (Estimated)
June 15, 2026
Last Updated
June 22, 2025
Record last verified: 2025-06
Data Sharing
- IPD Sharing
- Will not share