Association Between ABO Polymorphism and Gastric/Colorectal Cancers

NCT06149923 | Unknown

• 1 other identifier: ABO in gastric/colorectal canc
• Study Type: observational
• Target: 184
• Locations: 0 countries
• Sites: N/A

Brief Summary

To assess ABO gene polymorphism (rs8176746) in the patients histopathologically confirmed gastric and/or colorectal cancers relative to healthy controls by real time PCR.

Conditions

Gastric Cancer; Colo-rectal Cancer

Outcome Measures

Primary Outcomes (1)

• assess ABO gene polymorphism (rs8176746) in the patients histopathologically confirmed gastric and/colorectal cancers relative to healthy controls.

  assess ABO gene polymorphism (rs8176746) in the patients histopathologically confirmed gastric and/colorectal cancers relative to healthy controls by real-time PCR. and determine the impact of ABO phenotype and genotype on risk of development of gastric and/or colorectal cancers.

  Baseline

Study Arms (1)

cases

Patients that histopathologically confirmed gastric and/or colorectal cancer, males and females.

Genetic: quantitative Real-time PCR

Interventions

quantitative Real-time PCR GENETIC

: quantitative real time PCR using 7500 fast real time PCR (Applied Biosystems

cases

Eligibility Criteria

• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients that histopathologically confirmed gastric and/or colorectal cancer, males and females.

You may qualify if:

• Patients that histopathologically confirmed gastric and/or colorectal cancer.
• males and females.

You may not qualify if:

• Presence of other haematological , autoimmune disorders or other malignancies.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (11)

• Groot HE, Villegas Sierra LE, Said MA, Lipsic E, Karper JC, van der Harst P. Genetically Determined ABO Blood Group and its Associations With Health and Disease. Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):830-838. doi: 10.1161/ATVBAHA.119.313658. Epub 2020 Jan 23.

  PMID: 31969017 BACKGROUND

• Rummel SK, Ellsworth RE. The role of the histoblood ABO group in cancer. Future Sci OA. 2016 Mar 15;2(2):FSO107. doi: 10.4155/fsoa-2015-0012. eCollection 2016 Jun.

  PMID: 28031957 BACKGROUND

• Chen Z, Yang SH, Xu H, Li JJ. ABO blood group system and the coronary artery disease: an updated systematic review and meta-analysis. Sci Rep. 2016 Mar 18;6:23250. doi: 10.1038/srep23250.

  PMID: 26988722 BACKGROUND

• Rummel S, Shriver CD, Ellsworth RE. Relationships between the ABO blood group SNP rs505922 and breast cancer phenotypes: a genotype-phenotype correlation study. BMC Med Genet. 2012 May 29;13:41. doi: 10.1186/1471-2350-13-41.

  PMID: 22642827 BACKGROUND

• Zhou Y, Cui JG, Huang F, Zhang A, Li C, Zhao ZC, Li WD, Fu WH. Prognostic Factors for Survival in Node-Negative Gastric Cancer Patients Who Underwent Curative Resection. Scand J Surg. 2017 Sep;106(3):235-240. doi: 10.1177/1457496916677878. Epub 2017 Apr 4.

  PMID: 28376652 BACKGROUND

• Crew KD, Neugut AI. Epidemiology of gastric cancer. World J Gastroenterol. 2006 Jan 21;12(3):354-62. doi: 10.3748/wjg.v12.i3.354.

  PMID: 16489633 BACKGROUND

• Brenner H, Rothenbacher D, Arndt V. Epidemiology of stomach cancer. Methods Mol Biol. 2009;472:467-77. doi: 10.1007/978-1-60327-492-0_23.

  PMID: 19107449 BACKGROUND

• Sano T, Coit DG, Kim HH, Roviello F, Kassab P, Wittekind C, Yamamoto Y, Ohashi Y. Proposal of a new stage grouping of gastric cancer for TNM classification: International Gastric Cancer Association staging project. Gastric Cancer. 2017 Mar;20(2):217-225. doi: 10.1007/s10120-016-0601-9. Epub 2016 Feb 20.

  PMID: 26897166 BACKGROUND

• Urun Y, Ozdemir NY, Utkan G, Akbulut H, Savas B, Oksuzoglu B, Oztuna DG, Dogan I, Yalcin B, Senler FC, Onur H, Demirkazik A, Zengin N, Icli F. ABO and Rh blood groups and risk of colorectal adenocarcinoma. Asian Pac J Cancer Prev. 2012;13(12):6097-100. doi: 10.7314/apjcp.2012.13.12.6097.

  PMID: 23464411 BACKGROUND

• Nakao M, Matsuo K, Ito H, Shitara K, Hosono S, Watanabe M, Ito S, Sawaki A, Iida S, Sato S, Yatabe Y, Yamao K, Ueda R, Tajima K, Hamajima N, Tanaka H. ABO genotype and the risk of gastric cancer, atrophic gastritis, and Helicobacter pylori infection. Cancer Epidemiol Biomarkers Prev. 2011 Aug;20(8):1665-72. doi: 10.1158/1055-9965.EPI-11-0213. Epub 2011 Jun 15.

  PMID: 21680535 BACKGROUND

• Rizzato C, Campa D, Pezzilli R, Soucek P, Greenhalf W, Capurso G, Talar-Wojnarowska R, Heller A, Jamroziak K, Khaw KT, Key TJ, Bambi F, Landi S, Mohelnikova-Duchonova B, Vodickova L, Buchler MW, Bugert P, Vodicka P, Neoptolemos JP, Werner J, Hoheisel JD, Bauer AS, Giese N, Canzian F. ABO blood groups and pancreatic cancer risk and survival: results from the PANcreatic Disease ReseArch (PANDoRA) consortium. Oncol Rep. 2013 Apr;29(4):1637-44. doi: 10.3892/or.2013.2285. Epub 2013 Feb 12.

  PMID: 23403949 BACKGROUND

MeSH Terms

Conditions

Stomach Neoplasms; Colonic Neoplasms

Interventions

Real-Time Polymerase Chain Reaction

Condition Hierarchy (Ancestors)

Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Stomach Diseases; Colorectal Neoplasms; Intestinal Neoplasms; Colonic Diseases; Intestinal Diseases

Intervention Hierarchy (Ancestors)

Polymerase Chain Reaction; Nucleic Acid Amplification Techniques; Genetic Techniques; Investigative Techniques

Central Study Contacts

Wesam Ashraf Soliman

CONTACT

01095574120; wesamashraf27@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: doctor

Study Record Dates

• First Submitted: November 19, 2023
• First Posted: November 29, 2023
• Study Start: December 1, 2023
• Primary Completion: December 1, 2025
• Study Completion: January 1, 2026
• Last Updated: November 29, 2023

Record last verified: 2023-11