NCT06141811

Brief Summary

This is a follow-up study to evaluate the safety for the subjects with ALLO-ASC-DFU treatment in phase 3 clinical trial (ALLO-ASC-DFU-302) for 24 months

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
104

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Apr 2023

Typical duration for all trials

Geographic Reach
1 country

4 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 25, 2023

Completed
6 months until next milestone

First Submitted

Initial submission to the registry

November 2, 2023

Completed
19 days until next milestone

First Posted

Study publicly available on registry

November 21, 2023

Completed
2.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2025

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 31, 2026

Completed
Last Updated

December 13, 2024

Status Verified

December 1, 2024

Enrollment Period

2.7 years

First QC Date

November 2, 2023

Last Update Submit

December 10, 2024

Conditions

Outcome Measures

Primary Outcomes (4)

  • Evaluation of systemic tolerance through incidence of abnormal laboratory test results

    Up to 9 months

  • Evaluation of incidence of clinically significant change in physical examination and vital signs

    Up to 18 months

  • Evaluation of localized tolerance through incidence of clinically significant change about treatment area

    Up to 24 months

  • Evaluation of incidence of adverse events

    Up to 24 months

Study Arms (2)

ALLO-ASC-DFU

Subjects with ALLO-ASC-DFU treatment in phase 3 clinical trial of ALLO-ASC-DFU-302

Biological: ALLO-ASC-DFU

Vehicle sheet

Subjects with Vehicle sheet treatment in phase 3 clinical trial of ALLO-ASC-DFU-302

Procedure: Vehicle sheet

Interventions

ALLO-ASC-DFUBIOLOGICAL

Application of ALLO-ASC-DFU sheet to Diabetic Foot Ulcer. This study is a follow-up study without intervention.

ALLO-ASC-DFU
Vehicle sheetPROCEDURE

Application of Vehicle sheet to Diabetic Foot Ulcer. This study is a follow-up study without intervention.

Vehicle sheet

Eligibility Criteria

Age19 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

ubjects who are treated with ALLO-ASC-DFU sheet or Vehicle sheet in phase 3 clinical trial of ALLO-ASC-DFU-302.

You may qualify if:

  • Subjects who are treated with ALLO-ASC-DFU sheet or Vehicle sheet in phase 3 clinical trial of ALLO-ASC-DFU-302.
  • Subjects who are able to give written informed consent prior to study start and to comply with the study requirements.

You may not qualify if:

  • \. Subjects who are considered not suitable for the study by the principal investigator.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (4)

Soonchunhyang University Hospital

Bucheon-si, Gyeonggi-do, 14584, South Korea

RECRUITING

Bucheon ST. Mary's Hospital

Bucheon-si, Gyeonggi-do, 14647, South Korea

RECRUITING

Asan Medical Center

Seoul, 05505, South Korea

RECRUITING

Borame Medical Center

Seoul, 07061, South Korea

RECRUITING

MeSH Terms

Conditions

Diabetic Foot

Condition Hierarchy (Ancestors)

Diabetic AngiopathiesVascular DiseasesCardiovascular DiseasesFoot UlcerLeg UlcerSkin UlcerSkin DiseasesSkin and Connective Tissue DiseasesDiabetes ComplicationsDiabetes MellitusEndocrine System DiseasesDiabetic Neuropathies

Study Officials

  • ChangSik Park, MD. Ph D

    Asan Medical Center

    PRINCIPAL INVESTIGATOR
  • JiUng Bak, MD. Ph D

    Borame Medical Center

    PRINCIPAL INVESTIGATOR
  • DaeWon Jun, MD. Ph D

    Bucheon St. Mary's Hospital

    PRINCIPAL INVESTIGATOR
  • YoungKoo Lee, MD. Ph D

    Soonchunhyang University Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

ChangSik Park, MD. Ph D

CONTACT

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Target Duration
24 Months
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 2, 2023

First Posted

November 21, 2023

Study Start

April 25, 2023

Primary Completion

December 31, 2025

Study Completion

March 31, 2026

Last Updated

December 13, 2024

Record last verified: 2024-12

Locations