Effects of Dexmetomidine and Remifentanil Used for Controlled Hypotension in Septorhinoplasty Surgery on Cardiac Electrophysiology: Prospective Randomized Study

NCT06138574 | Unknown

• 1 other identifier: HTosun
• Study Type: interventional
• Target: 72
• Locations: 0 countries
• Sites: N/A

Brief Summary

Our aim in this treatment was to reveal the effects of remifentanil and dexmetomidine, which we used to provide controlled hypotension in septorhinoplasty surgery, on cardiac electrophysiology. We planned to compare the patients by recording preoperative and postoperative ECGs. We also planned to record the patients' intraoperative blood pressure, saturation, and pulse rate, rickeragitation scale, and vas score.

Conditions

Rhinoplasty Surgery

Outcome Measures

Primary Outcomes (1)

• iceb

  Qt\\Qrs

  preoperative and postoperative (immediatly after extubation)

Secondary Outcomes (4)

• Riker Agitation Scale

  Immediately after extubation

• mean arterial pressure

  when you come to the operating room table after anesthesia induction Intraoperative 30 minutes after extubasion

• heart rate

  when you come to the operating room table after anesthesia induction Intraoperative 30 minutes after extubasion

• Numeric Rating Scale

  Postoperative 0-2 hours

Study Arms (2)

Effects of Dexmetomidine

ACTIVE COMPARATOR

Patients in this group will be given dexmedetomidine infusion during the intraoperative period to provide controlled hypotension.

Drug: Dexmedetomidine

Effects of Remifentanil

ACTIVE COMPARATOR

Patients in this group will be given remifentanil infusion during the intraoperative period to provide controlled hypotension.

Drug: Remifentanil

Interventions

Dexmedetomidine DRUG

After the induction of general anesthesia, one group (Group: 1) will be administered dexmedotomidin infizyon and group (Group :2)remifentanil

Effects of Dexmetomidine

Remifentanil DRUG

Remifentanil

Effects of Remifentanil

Eligibility Criteria

• Age: 17 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• patients with an ASA score of I and between the ages of 17-45 years, who were to undergo general anesthesia with sevofulurane were included in the study.

You may not qualify if:

• Patients aged \<17 and \>45 years, patients with liver and/or kidney failure, obese patients (BMI \>30), trauma patients, ASA II-III-IV patients, patients with bleeding disorders, those using drugs that may affect the coagulation system, patients with cardiomyopathy, cerebrovascular disease, immobility, and malnutrition were excluded from the study.

Sponsors & Collaborators

• Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital: lead

MeSH Terms

Interventions

Dexmedetomidine; Remifentanil

Intervention Hierarchy (Ancestors)

Imidazoles; Azoles; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Propionates; Acids, Acyclic; Carboxylic Acids; Organic Chemicals; Piperidines

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: HTosunSoner

Study Record Dates

• First Submitted: November 14, 2023
• First Posted: November 18, 2023
• Study Start: December 1, 2023
• Primary Completion: February 1, 2024
• Study Completion: March 30, 2024
• Last Updated: November 18, 2023

Record last verified: 2023-11