Nasopharyngeal Carcinoma Treated With Reduced Volume Intensity Modulated Radiation Therapy:10-Year Outcome and Late Toxicity, Quality of Life
A Comprehensive Prospective Study on the 10-Year Outcome and Late Toxicity, Quality of Life of Reduced Volume Intensity Modulated Radiation Therapy in Nasopharyngeal Carcinoma
1 other identifier
observational
500
1 country
1
Brief Summary
Nasopharyngeal carcinoma (NPC) is a type of head and neck cancer. The last three decades of research in head and neck radiation oncology have largely focused on improvements in survival, which have mostly come at the cost of long term toxicity for surviving patients.This is an observational study that is being done to evaluate the long-term efficacy, learn about the toxicity and quality of life that survivors of nasopharyngeal carcinoma may have following treated with reduced volume intensity modulated radiation therapy.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Dec 2023
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 5, 2023
CompletedFirst Posted
Study publicly available on registry
November 18, 2023
CompletedStudy Start
First participant enrolled
December 1, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2024
CompletedNovember 18, 2023
November 1, 2023
1 year
November 5, 2023
November 16, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
Overall survival
Overall survival is calculated from diagnosis to death from any cause
10 years
Secondary Outcomes (6)
Loco-regional failure-free survival
10 years
Failure-free survival
10 years
Distant failure-free survival
10 years
Quality of Life Questionnaires QLQ-C30
1year
Quality of Life Questionnaires
1year
- +1 more secondary outcomes
Eligibility Criteria
Histologically diagnosed non-metastatic Nasopharyngeal carcinoma (NPC) patients who were treated with Reduced Volume Intensity Modulated Radiation Therapy.
You may qualify if:
- Received treatment with Reduced Volume Intensity Modulated Radiation Therapy
- Age 18 or above, upper limit 65
- Ability to comply with the protocol
You may not qualify if:
- History of recurrent nasopharyngeal disease
- A history of any physical, psychological or social condition which would impair with the ability of the patient to cooperate in this study
- Unable to provide consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of radiation oncology, Fujian cancer hospital
Fuzhou, Fujian, 350014, China
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER GOV
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 5, 2023
First Posted
November 18, 2023
Study Start
December 1, 2023
Primary Completion
December 1, 2024
Study Completion
December 1, 2024
Last Updated
November 18, 2023
Record last verified: 2023-11
Data Sharing
- IPD Sharing
- Will not share