Therapeutic Effect of Blood Flow Reconstruction in IVADA

NCT06134557 | Unknown

• 1 other identifier: KYLL-202306-092
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

IVADA (Intracranial vertebral artery dissecting aneurysms）is one of the causes of subarachnoid hemorrhage or posterior circulation ischemia with high mortality and disability. Current endovascular therapies for IVADA mainly include parent artery occlusion and endovascular blood reconstructive techniques. The method of parent artery occlusion requires the sacrifice of one vertebral artery. For the IVADA patients whose dissection involves PICA（posterior inferior cerebellar artery）or anterior spinal artery, severe ischemia even infarction of brain stem or cerebellar may be caused after parent artery occlusion , they are usually irreversible damage, so that method are rarely used now.Endovascular flood reconstructive techniques has become the mainstream, including stent-alone or overlapping stent treatment ,stent-assisted coiling techniques, single flow diverter(FD) stents or flow diverter assisted coil, etc.With the improvements in stents, flow diverter stent is efficient, while they are associated with the risk of ischemia, especially when vital arterial branches are covered. It has been reported that FD techniques have certain advantages over traditional stents in the treatment of anterior circulating intracranial aneurysms. In the treatment of posterior circulating aneurysms, perioperative ischemic complications increase due to their influence on the blood flow of perforator arteries, but there are few long-term observations at present. Currently, studies directly contrasting flow diverter and conventional stents in patients with IVADA are rare. Therefore, we performed the study to compare the safety and efficacy between flow diverters and conventional stents in IVADA patients undergoing endovascular therapy. Stent-assisted coiling is the preferred option for most surgeons. In addition,It is believed that dense packing is not necessary as long as the aneurysm neck is covered to isolate the dissection. How ever,whether it is really necessary to adjunct coil,and if it is necessary, what is the ideal packing density of coils, there is no clear conclusion at present.This study aimed to compare the safety and efficacy between flow diverter and conventional stents in patients with IVADA, determine the ideal packing density of coils after FD stent placement,and to observe the hemodynamic changes before and after the treatment of FD stent.

Conditions

Intracranial Aneurysm

Outcome Measures

Primary Outcomes (2)

• complete aneurysm occlusion

  whether obtain complete aneurysm occlusion

  6 months postoperatively

• Complications

  Ischemic or hemorrhagic complications

  during hospitalization（up to day 3） and post-discharge（12months post-discharge）

Study Arms (2)

flow diverter stents

single flow diverter(FD) stents or flow diverter assisted coil

Procedure: conventional stents

conventional stents

stent-alone or overlapping stent treatment ,stent-assisted coiling techniques

Procedure: conventional stents

Interventions

conventional stents PROCEDURE

performed the study to compare the safety and efficacy between flow diverters and conventional stents in IVADA patients undergoing endovascular therapy. Stent-assisted coiling is the preferred option for most surgeons. In addition,It is believed that dense packing is not necessary as long as the aneurysm neck is covered to isolate the dissection. How ever,whether it is really necessary to adjunct coil,and if it is necesary, what is the ideal packing density of coils, there is no clear conclusion at present.This study aimed to compare the safety and efficacy between flow diverter and conventional stents in patients with IVADA, determine the ideal packing density of coils after FD stent placement,and to observe the hemodynamic changes before and after the treatment of FD stent.

conventional stents; flow diverter stents

Eligibility Criteria

• Age: 30 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients diagnosed with IVADA who underwent endovascular blood reconstructive tratement in our institution

You may qualify if:

• Patients with asymptomatic or SAH symptoms of intracranial hypertension
• After a preliminary diagnosis of cerebrovascular CTA or MRA, DSA angiography confirmed IVADA
• IVADA involves intracranial segment of vertebral artery (V4 )

You may not qualify if:

• : Patients with SAH caused by trauma or other cerebrovascular diseases
• : IVADA involves the extracranial vertebral artery
• : Vertebrobasilar artery tortuosity and dilatation

Sponsors & Collaborators

• Qilu Hospital of Shandong University: lead

Study Sites (1)

Qilu Hospital of Shandong University

Jinan, China

RECRUITING

Related Publications (51)

• Suzuki H, Kitagawa T, Gotoh M, Mitsueda-Ono T, Matsui M. Cervical Cord Infarction Caused by Dissection of the Intracranial Segment of the Vertebral Artery. Intern Med. 2018 Nov 15;57(22):3321-3324. doi: 10.2169/internalmedicine.0608-17. Epub 2018 Jul 6.

  PMID: 29984769 RESULT

• Debette S, Compter A, Labeyrie MA, Uyttenboogaart M, Metso TM, Majersik JJ, Goeggel-Simonetti B, Engelter ST, Pezzini A, Bijlenga P, Southerland AM, Naggara O, Bejot Y, Cole JW, Ducros A, Giacalone G, Schilling S, Reiner P, Sarikaya H, Welleweerd JC, Kappelle LJ, de Borst GJ, Bonati LH, Jung S, Thijs V, Martin JJ, Brandt T, Grond-Ginsbach C, Kloss M, Mizutani T, Minematsu K, Meschia JF, Pereira VM, Bersano A, Touze E, Lyrer PA, Leys D, Chabriat H, Markus HS, Worrall BB, Chabrier S, Baumgartner R, Stapf C, Tatlisumak T, Arnold M, Bousser MG. Epidemiology, pathophysiology, diagnosis, and management of intracranial artery dissection. Lancet Neurol. 2015 Jun;14(6):640-54. doi: 10.1016/S1474-4422(15)00009-5.

  PMID: 25987283 RESULT

• Mizutani T, Aruga T, Kirino T, Miki Y, Saito I, Tsuchida T. Recurrent subarachnoid hemorrhage from untreated ruptured vertebrobasilar dissecting aneurysms. Neurosurgery. 1995 May;36(5):905-11; discussion 912-3. doi: 10.1227/00006123-199505000-00003.

  PMID: 7791980 RESULT

• Gottesman RF, Sharma P, Robinson KA, Arnan M, Tsui M, Saber-Tehrani A, Newman-Toker DE. Imaging characteristics of symptomatic vertebral artery dissection: a systematic review. Neurologist. 2012 Sep;18(5):255-60. doi: 10.1097/NRL.0b013e3182675511.

  PMID: 22931729 RESULT

• Han M, Rim NJ, Lee JS, Kim SY, Choi JW. Feasibility of high-resolution MR imaging for the diagnosis of intracranial vertebrobasilar artery dissection. Eur Radiol. 2014 Dec;24(12):3017-24. doi: 10.1007/s00330-014-3296-5. Epub 2014 Jul 14.

  PMID: 25017728 RESULT

• Zang YZ, Wang ZG, Wang CW, Zhang Y, Ding X, Wang XF. [Clinical analysis of endovascular strategies in the treatment of vertebrobasilar dissecting aneurysms]. Zhonghua Yi Xue Za Zhi. 2016 Nov 8;96(41):3329-3332. doi: 10.3760/cma.j.issn.0376-2491.2016.41.011. Chinese.

  PMID: 27852380 RESULT

• Kim BM, Shin YS, Baik MW, Lee DH, Jeon P, Baik SK, Lee TH, Kang DH, Suh SI, Byun JS, Jung JY, Kwon K, Kim DJ, Park KY, Kim BS, Park JC, Kim SR, Kim YW, Kim H, Jo K, Yoon CH, Kim YS. Pipeline Embolization Device for Large/Giant or Fusiform Aneurysms: An Initial Multi-Center Experience in Korea. Neurointervention. 2016 Mar;11(1):10-7. doi: 10.5469/neuroint.2016.11.1.10. Epub 2016 Mar 3.

  PMID: 26958407 RESULT

• Acke F, Acou M, Hemelsoet D. Basilar artery dissection. Acta Neurol Belg. 2011 Dec;111(4):376. No abstract available.

  PMID: 22368989 RESULT

• Conforto AB. Challenges in diagnosis and treatment of cervico-cephalic arterial dissections. Arq Neuropsiquiatr. 2016 Apr;74(4):273-4. doi: 10.1590/0004-282X20160039. No abstract available.

  PMID: 27096998 RESULT

• Choi JW, Han DH, Kang KD, Jung HY, Renshaw PF. Aerobic exercise and attention deficit hyperactivity disorder: brain research. Med Sci Sports Exerc. 2015 Jan;47(1):33-9. doi: 10.1249/MSS.0000000000000373.

  PMID: 24824770 RESULT

• Wang Y, Cui L, Ji X, Dong Q, Zeng J, Wang Y, Zhou Y, Zhao X, Wang C, Liu L, Nguyen-Huynh MN, Claiborne Johnston S, Wong L, Li H; China National Stroke Registry Investigators. The China National Stroke Registry for patients with acute cerebrovascular events: design, rationale, and baseline patient characteristics. Int J Stroke. 2011 Aug;6(4):355-61. doi: 10.1111/j.1747-4949.2011.00584.x. Epub 2011 Feb 17.

  PMID: 21609414 RESULT

• Bejot Y, Daubail B, Debette S, Durier J, Giroud M. Incidence and outcome of cerebrovascular events related to cervical artery dissection: the Dijon Stroke Registry. Int J Stroke. 2014 Oct;9(7):879-82. doi: 10.1111/ijs.12154. Epub 2013 Oct 22.

  PMID: 24148660 RESULT

• Kapsalaki EZ, Rountas CD, Fountas KN. The Role of 3 Tesla MRA in the Detection of Intracranial Aneurysms. Int J Vasc Med. 2012;2012:792834. doi: 10.1155/2012/792834. Epub 2012 Jan 16.

  PMID: 22292121 RESULT

• Balik V, Yamada Y, Talari S, Kei Y, Sano H, Suyama D, Kawase T, Takagi K, Takizawa K, Kato Y. State-of-art in surgical treatment of dissecting posterior circulation intracranial aneurysms. Neurosurg Rev. 2018 Jan;41(1):31-45. doi: 10.1007/s10143-016-0749-0. Epub 2016 May 24.

  PMID: 27215913 RESULT

• Darsaut TE, Findlay JM, Magro E, Kotowski M, Roy D, Weill A, Bojanowski MW, Chaalala C, Iancu D, Lesiuk H, Sinclair J, Scholtes F, Martin D, Chow MM, O'Kelly CJ, Wong JH, Butcher K, Fox AJ, Arthur AS, Guilbert F, Tian L, Chagnon M, Nolet S, Gevry G, Raymond J. Surgical clipping or endovascular coiling for unruptured intracranial aneurysms: a pragmatic randomised trial. J Neurol Neurosurg Psychiatry. 2017 Aug;88(8):663-668. doi: 10.1136/jnnp-2016-315433. Epub 2017 Jun 20.

  PMID: 28634280 RESULT

• Shi L, Xu K, Sun X, Yu J. Therapeutic Progress in Treating Vertebral Dissecting Aneurysms Involving the Posterior Inferior Cerebellar Artery. Int J Med Sci. 2016 Jun 30;13(7):540-55. doi: 10.7150/ijms.15233. eCollection 2016.

  PMID: 27429591 RESULT

• Ortiz J, Ruland S. Cervicocerebral artery dissection. Curr Opin Cardiol. 2015 Nov;30(6):603-10. doi: 10.1097/HCO.0000000000000224.

  PMID: 26447501 RESULT

• Sonmez O, Brinjikji W, Murad MH, Lanzino G. Deconstructive and Reconstructive Techniques in Treatment of Vertebrobasilar Dissecting Aneurysms: A Systematic Review and Meta-Analysis. AJNR Am J Neuroradiol. 2015 Jul;36(7):1293-8. doi: 10.3174/ajnr.A4360. Epub 2015 May 7.

  PMID: 25953763 RESULT

• Ohta H, Natarajan SK, Hauck EF, Khalessi AA, Siddiqui AH, Hopkins LN, Levy EI. Endovascular stent therapy for extracranial and intracranial carotid artery dissection: single-center experience. J Neurosurg. 2011 Jul;115(1):91-100. doi: 10.3171/2011.1.JNS091806. Epub 2011 Mar 18.

  PMID: 21417710 RESULT

• Wang Y, Zhao C, Hao X, Wang C, Wang Z. Endovascular interventional therapy and classification of vertebral artery dissecting aneurysms. Exp Ther Med. 2014 Nov;8(5):1409-1415. doi: 10.3892/etm.2014.1961. Epub 2014 Sep 12.

  PMID: 25289031 RESULT

• Park W, Ahn JS, Park JC, Kwun BD, Kim CJ. Occipital artery-posterior inferior cerebellar artery bypass for the treatment of aneurysms arising from the vertebral artery and its branches. World Neurosurg. 2014 Nov;82(5):714-21. doi: 10.1016/j.wneu.2014.06.053. Epub 2014 Jul 3.

  PMID: 24998497 RESULT

• Lylyk P, Ceratto R, Hurvitz D, Basso A. Treatment of a vertebral dissecting aneurysm with stents and coils: technical case report. Neurosurgery. 1998 Aug;43(2):385-8. doi: 10.1097/00006123-199808000-00132.

  PMID: 9696097 RESULT

• Suzuki S, Kurata A, Iwamoto K, Sato K, Niki J, Miyazaki T, Yamada M, Oka H, Fujii K, Kan S. Endovascular surgery using stents for vertebral artery dissecting aneurysms and a review of the literature. Minim Invasive Neurosurg. 2008 Aug;51(4):193-8. doi: 10.1055/s-2008-1073172.

  PMID: 18683108 RESULT

• Li H, Gao BL, Li CH, Wang JW, Liu JF, Yang ST. Endovascular Retreatment of Cerebral Aneurysms Previously Treated with Endovascular Embolization. J Neurol Surg A Cent Eur Neurosurg. 2020 May;81(3):207-212. doi: 10.1055/s-0039-1685513. Epub 2019 Nov 19.

  PMID: 31746449 RESULT

• Chalouhi N, Tjoumakaris S, Gonzalez LF, Dumont AS, Starke RM, Hasan D, Wu C, Singhal S, Moukarzel LA, Rosenwasser R, Jabbour P. Coiling of large and giant aneurysms: complications and long-term results of 334 cases. AJNR Am J Neuroradiol. 2014 Mar;35(3):546-52. doi: 10.3174/ajnr.A3696. Epub 2013 Aug 14.

  PMID: 23945229 RESULT

• Endo H, Matsumoto Y, Kondo R, Sato K, Fujimura M, Inoue T, Shimizu H, Takahashi A, Tominaga T. Medullary infarction as a poor prognostic factor after internal coil trapping of a ruptured vertebral artery dissection. J Neurosurg. 2013 Jan;118(1):131-9. doi: 10.3171/2012.9.JNS12566. Epub 2012 Oct 5.

  PMID: 23039149 RESULT

• Khattak YJ, Sibaie AA, Anwar M, Sayani R. Stents and Stent Mimickers in Endovascular Management of Wide-neck Intracranial Aneurysms. Cureus. 2018 Oct 5;10(10):e3420. doi: 10.7759/cureus.3420.

  PMID: 30542634 RESULT

• Liu J, Li X, Sun S, Wang Y, Zang P. Clinical and Angiographic Outcomes of Endovascular Treatment for Ruptured Posterior Circulation Cerebral Aneurysms. Turk Neurosurg. 2016;26(4):513-7. doi: 10.5137/1019-5149.JTN.6570-12.1.

  PMID: 27400096 RESULT

• Iannaccone Farkasova S, Sopkova D, Svajdler M Jr, Farkas D, Mistrikova L, Mezencev R. Chronic dissecting aneurysm of ascending aorta with a large intramural thrombus and isolated aortic defects. Cesk Patol. 2019 Spring;55(2):115-119.

  PMID: 31181944 RESULT

• Jin SC, Kwon DH, Choi CG, Ahn JS, Kwun BD. Endovascular strategies for vertebrobasilar dissecting aneurysms. AJNR Am J Neuroradiol. 2009 Sep;30(8):1518-23. doi: 10.3174/ajnr.A1621. Epub 2009 May 27.

  PMID: 19474118 RESULT

• Marosfoi M, Langan ET, Strittmatter L, van der Marel K, Vedantham S, Arends J, Lylyk IR, Loganathan S, Hendricks GM, Szikora I, Puri AS, Wakhloo AK, Gounis MJ. In situ tissue engineering: endothelial growth patterns as a function of flow diverter design. J Neurointerv Surg. 2017 Oct;9(10):994-998. doi: 10.1136/neurintsurg-2016-012669. Epub 2016 Oct 5.

  PMID: 27707872 RESULT

• Brinjikji W, Murad MH, Lanzino G, Cloft HJ, Kallmes DF. Endovascular treatment of intracranial aneurysms with flow diverters: a meta-analysis. Stroke. 2013 Feb;44(2):442-7. doi: 10.1161/STROKEAHA.112.678151. Epub 2013 Jan 15.

  PMID: 23321438 RESULT

• Kan P, Sweid A, Srivatsan A, Jabbour P. Expanding Indications for Flow Diverters: Ruptured Aneurysms, Blister Aneurysms, and Dissecting Aneurysms. Neurosurgery. 2020 Jan 1;86(Suppl 1):S96-S103. doi: 10.1093/neuros/nyz304.

  PMID: 31838529 RESULT

• Deng Q, Feng W, Hai H, Liu J. Evaluation of the safety and efficacy of a Pipeline Flex embolization device for treatment of large, wide-necked intracranial aneurysms. J Interv Med. 2019 Apr 30;1(4):229-233. doi: 10.19779/j.cnki.2096-3602.2018.04.06. eCollection 2018 Nov.

  PMID: 34805855 RESULT

• Adeeb N, Griessenauer CJ, Dmytriw AA, Shallwani H, Gupta R, Foreman PM, Shakir H, Moore J, Limbucci N, Mangiafico S, Kumar A, Michelozzi C, Zhang Y, Pereira VM, Matouk CC, Harrigan MR, Siddiqui AH, Levy EI, Renieri L, Marotta TR, Cognard C, Ogilvy CS, Thomas AJ. Risk of Branch Occlusion and Ischemic Complications with the Pipeline Embolization Device in the Treatment of Posterior Circulation Aneurysms. AJNR Am J Neuroradiol. 2018 Jul;39(7):1303-1309. doi: 10.3174/ajnr.A5696. Epub 2018 Jun 7.

  PMID: 29880475 RESULT

• Wang K, Tian Z, Chen J, Liu J, Wang Y, Zhang H, Wang J, Zhang Y, Yang X. Risk Factors of Recurrence after Stent(s)-Assisted Coiling of Intracranial Vertebrobasilar Dissecting Aneurysms: A Multicenter Study. Front Neurol. 2017 Sep 14;8:482. doi: 10.3389/fneur.2017.00482. eCollection 2017.

  PMID: 28959233 RESULT

• Cagnazzo F, Perrini P, Dargazanli C, Lefevre PH, Gascou G, Morganti R, di Carlo D, Derraz I, Riquelme C, Bonafe A, Costalat V. Treatment of Unruptured Distal Anterior Circulation Aneurysms with Flow-Diverter Stents: A Meta-Analysis. AJNR Am J Neuroradiol. 2019 Apr;40(4):687-693. doi: 10.3174/ajnr.A6002. Epub 2019 Mar 14.

  PMID: 30872418 RESULT

• Bender MT, Colby GP, Jiang B, Lin LM, Campos JK, Xu R, Westbroek EM, Vo CD, Zarrin DA, Caplan JM, Huang J, Tamargo RJ, Coon AL. Flow Diversion of Posterior Circulation Cerebral Aneurysms: A Single-Institution Series of 59 Cases. Neurosurgery. 2019 Jan 1;84(1):206-216. doi: 10.1093/neuros/nyy076.

  PMID: 29608702 RESULT

• Griessenauer CJ, Ogilvy CS, Adeeb N, Dmytriw AA, Foreman PM, Shallwani H, Limbucci N, Mangiafico S, Kumar A, Michelozzi C, Krings T, Pereira VM, Matouk CC, Harrigan MR, Shakir HJ, Siddiqui AH, Levy EI, Renieri L, Marotta TR, Cognard C, Thomas AJ. Pipeline embolization of posterior circulation aneurysms: a multicenter study of 131 aneurysms. J Neurosurg. 2019 Mar 1;130(3):923-935. doi: 10.3171/2017.9.JNS171376. Epub 2018 May 4.

  PMID: 29726768 RESULT

• Albuquerque FC, Park MS, Abla AA, Crowley RW, Ducruet AF, McDougall CG. A reappraisal of the Pipeline embolization device for the treatment of posterior circulation aneurysms. J Neurointerv Surg. 2015 Sep;7(9):641-5. doi: 10.1136/neurintsurg-2014-011340. Epub 2014 Aug 4.

  PMID: 25092926 RESULT

• Lopes DK, Jang DK, Cekirge S, Fiorella D, Hanel RA, Kallmes DF, Levy EI, Lylyk P. Morbidity and Mortality in Patients With Posterior Circulation Aneurysms Treated With the Pipeline Embolization Device: A Subgroup Analysis of the International Retrospective Study of the Pipeline Embolization Device. Neurosurgery. 2018 Sep 1;83(3):488-500. doi: 10.1093/neuros/nyx467.

  PMID: 28945879 RESULT

• Kuhn AL, Kan P, Massari F, Lozano JD, Hou SY, Howk M, Gounis MJ, Wakhloo AK, Puri AS. Endovascular reconstruction of unruptured intradural vertebral artery dissecting aneurysms with the Pipeline embolization device. J Neurointerv Surg. 2016 Oct;8(10):1048-51. doi: 10.1136/neurintsurg-2015-012028. Epub 2015 Nov 6.

  PMID: 26546600 RESULT

• Fischer S, Perez MA, Kurre W, Albes G, Bazner H, Henkes H. Pipeline embolization device for the treatment of intra- and extracranial fusiform and dissecting aneurysms: initial experience and long-term follow-up. Neurosurgery. 2014 Oct;75(4):364-74; discussion 374. doi: 10.1227/NEU.0000000000000431.

  PMID: 24871140 RESULT

• Corley JA, Zomorodi A, Gonzalez LF. Treatment of Dissecting Distal Vertebral Artery (V4) Aneurysms With Flow Diverters. Oper Neurosurg. 2018 Jul 1;15(1):1-9. doi: 10.1093/ons/opx180.

  PMID: 28962011 RESULT

• Tan LA, Moftakhar R, Lopes DK. Treatment of a ruptured vertebrobasilar fusiform aneurysm using pipeline embolization device. J Cerebrovasc Endovasc Neurosurg. 2013 Mar;15(1):30-3. doi: 10.7461/jcen.2013.15.1.30. Epub 2013 Mar 31.

  PMID: 23593603 RESULT

• Narata AP, Yilmaz H, Schaller K, Lovblad KO, Pereira VM. Flow-diverting stent for ruptured intracranial dissecting aneurysm of vertebral artery. Neurosurgery. 2012 Apr;70(4):982-8; discussion 988-9. doi: 10.1227/NEU.0b013e318236715e.

  PMID: 21937937 RESULT

• Guerrero WR, Ortega-Gutierrez S, Hayakawa M, Derdeyn CP, Rossen JD, Hasan D, Samaniego EA. Endovascular Treatment of Ruptured Vertebrobasilar Dissecting Aneurysms Using Flow Diversion Embolization Devices: Single-Institution Experience. World Neurosurg. 2018 Jan;109:e164-e169. doi: 10.1016/j.wneu.2017.09.125. Epub 2017 Oct 5.

  PMID: 28987840 RESULT

• Maus V, Mpotsaris A, Dorn F, Mohlenbruch M, Borggrefe J, Stavrinou P, Abdullayev N, Barnikol UB, Liebig T, Kabbasch C. The Use of Flow Diverter in Ruptured, Dissecting Intracranial Aneurysms of the Posterior Circulation. World Neurosurg. 2018 Mar;111:e424-e433. doi: 10.1016/j.wneu.2017.12.095. Epub 2017 Dec 23.

  PMID: 29277587 RESULT

• Lin N, Brouillard AM, Krishna C, Mokin M, Natarajan SK, Sonig A, Snyder KV, Levy EI, Siddiqui AH. Use of coils in conjunction with the pipeline embolization device for treatment of intracranial aneurysms. Neurosurgery. 2015 Feb;76(2):142-9. doi: 10.1227/NEU.0000000000000579.

  PMID: 25255261 RESULT

• Chong W, Zhang Y, Qian Y, Lai L, Parker G, Mitchell K. Computational hemodynamics analysis of intracranial aneurysms treated with flow diverters: correlation with clinical outcomes. AJNR Am J Neuroradiol. 2014 Jan;35(1):136-42. doi: 10.3174/ajnr.A3790. Epub 2013 Nov 28.

  PMID: 24287091 RESULT

• Zhang T, Zhong W, Zhou D, Xu Y, Li M, Zhuang J, Wang D, Su W, Wang Y. Treatment of unruptured intracranial vertebral artery dissection aneurysms with Flow Diverter compared with conventional stent-assisted coiling-a single-center study. Acta Neurochir (Wien). 2024 Dec 18;166(1):506. doi: 10.1007/s00701-024-06398-z.

  PMID: 39690339 DERIVED

MeSH Terms

Conditions

Intracranial Aneurysm

Condition Hierarchy (Ancestors)

Intracranial Arterial Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Aneurysm; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Yunyan Wang

  Medical Ethics Committee of Qilu Hospital of Shandong University

  STUDY CHAIR

• Weiying Zhong

  Medical Ethics Committee of Qilu Hospital of Shandong University

  STUDY DIRECTOR

• Maogui li

  Medical Ethics Committee of Qilu Hospital of Shandong University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Tongfu Zhang

CONTACT

0086-18054566265; 532323616@qq.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 5, 2023
• First Posted: November 18, 2023
• Study Start: December 20, 2023
• Primary Completion: December 31, 2023
• Study Completion: February 28, 2024
• Last Updated: February 23, 2024

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)