Lung Cancer Screening Eligibility Assessment

NCT06133816 | Completed Results

• 3 other identifiers: UPCC 16523P50CA271338-02853337
• Study Type: interventional
• Target: 6,125
• Locations: 1 country
• Sites: 1

Brief Summary

The primary purpose of this study evaluate if different messaging impacts response rates to a brief survey (i.e., the simplified eligibility tool) that is designed to estimate pack-year eligibility for lung cancer screening (LCS). This will help inform the best way to increase response rates to the tool in future intervention studies designed to increase LCS, and expand upon survey methodology in general.

Conditions

Lung Cancer

Keywords

Lung Cancer Screening

Outcome Measures

Primary Outcomes (1)

• Full Survey Completion

  The proportion of participants that answers all three survey questions via text message among all those randomized.

  7 days

Secondary Outcomes (1)

• Partial Survey Completion

  7 days

Study Arms (12)

Arm 1 (Introductory Message A + Tobacco Use Message A + Incentive)

EXPERIMENTAL

Participants will receive two framed messages (AA) plus an incentive

Behavioral: Framed Introductory Message A; Behavioral: Framed Tobacco Use Message A; Behavioral: Financial Incentive

Arm 2 (Introductory Message A + Tobacco Use Message A)

EXPERIMENTAL

Participants will receive two framed messages (AA)

Behavioral: Framed Introductory Message A; Behavioral: Framed Tobacco Use Message A

Arm 3 (Introductory Message A + Tobacco Use Message B + Incentive)

EXPERIMENTAL

Participants will receive two framed messages (AB) plus an incentive

Behavioral: Framed Introductory Message A; Behavioral: Framed Tobacco Use Message B; Behavioral: Financial Incentive

Arm 4 (Introductory Message A + Tobacco Use Message B)

EXPERIMENTAL

Participants will receive two framed messages (AB)

Behavioral: Framed Introductory Message A; Behavioral: Framed Tobacco Use Message B

Arm 5 (Introductory Message B + Tobacco Use Message A + Incentive)

EXPERIMENTAL

Participants will receive two framed messages (BA) plus an incentive

Behavioral: Framed Introductory Message B; Behavioral: Framed Tobacco Use Message A; Behavioral: Financial Incentive

Arm 6 (Introductory Message B + Tobacco Use Message A)

EXPERIMENTAL

Participants will receive two framed messages (BA)

Behavioral: Framed Introductory Message B; Behavioral: Framed Tobacco Use Message A

Arm 7 (Introductory Message B + Tobacco Use Message B + Incentive)

EXPERIMENTAL

Participants will receive two framed messages (BB) plus an incentive

Behavioral: Framed Introductory Message B; Behavioral: Framed Tobacco Use Message B; Behavioral: Financial Incentive

Arm 8 (Introductory Message B + Tobacco Use Message B)

EXPERIMENTAL

Participants will receive two framed messages (BB)

Behavioral: Framed Introductory Message B; Behavioral: Framed Tobacco Use Message B

Arm 9 (Introductory Message C + Tobacco Use Message A + Incentive)

EXPERIMENTAL

Participants will receive two framed messages (CA) plus an incentive

Behavioral: Framed Introductory Message C; Behavioral: Framed Tobacco Use Message A; Behavioral: Financial Incentive

Arm 10 (Introductory Message C + Tobacco Use Message A)

EXPERIMENTAL

Participants will receive two framed message (CA)

Behavioral: Framed Introductory Message C; Behavioral: Framed Tobacco Use Message A

Arm 11 (Introductory Message C + Tobacco Use Message B + Incentive)

EXPERIMENTAL

Participants will receive two framed messages (CB) plus an incentive

Behavioral: Framed Introductory Message C; Behavioral: Framed Tobacco Use Message B; Behavioral: Financial Incentive

Arm 12 (Introductory Message C + Tobacco Use Message B)

EXPERIMENTAL

Participants will receive two framed messages (CB)

Behavioral: Framed Introductory Message C; Behavioral: Framed Tobacco Use Message B

Interventions

Framed Introductory Message A BEHAVIORAL

Randomly assign patients to receive introductory message encouraging them to complete the survey (version A).

Arm 1 (Introductory Message A + Tobacco Use Message A + Incentive); Arm 2 (Introductory Message A + Tobacco Use Message A); Arm 3 (Introductory Message A + Tobacco Use Message B + Incentive); Arm 4 (Introductory Message A + Tobacco Use Message B)

Framed Introductory Message B BEHAVIORAL

Randomly assign patients to receive introductory message encouraging them to complete the survey (version B).

Arm 5 (Introductory Message B + Tobacco Use Message A + Incentive); Arm 6 (Introductory Message B + Tobacco Use Message A); Arm 7 (Introductory Message B + Tobacco Use Message B + Incentive); Arm 8 (Introductory Message B + Tobacco Use Message B)

Framed Introductory Message C BEHAVIORAL

Randomly assign patients to receive introductory message encouraging them to complete the survey (version C).

Arm 10 (Introductory Message C + Tobacco Use Message A); Arm 11 (Introductory Message C + Tobacco Use Message B + Incentive); Arm 12 (Introductory Message C + Tobacco Use Message B); Arm 9 (Introductory Message C + Tobacco Use Message A + Incentive)

Framed Tobacco Use Message A BEHAVIORAL

Randomly assign patients to receive norming message related to tobacco use (version A).

Arm 1 (Introductory Message A + Tobacco Use Message A + Incentive); Arm 10 (Introductory Message C + Tobacco Use Message A); Arm 2 (Introductory Message A + Tobacco Use Message A); Arm 5 (Introductory Message B + Tobacco Use Message A + Incentive); Arm 6 (Introductory Message B + Tobacco Use Message A); Arm 9 (Introductory Message C + Tobacco Use Message A + Incentive)

Framed Tobacco Use Message B BEHAVIORAL

Randomly assign patients to receive norming message related to tobacco use (version B).

Arm 11 (Introductory Message C + Tobacco Use Message B + Incentive); Arm 12 (Introductory Message C + Tobacco Use Message B); Arm 3 (Introductory Message A + Tobacco Use Message B + Incentive); Arm 4 (Introductory Message A + Tobacco Use Message B); Arm 7 (Introductory Message B + Tobacco Use Message B + Incentive); Arm 8 (Introductory Message B + Tobacco Use Message B)

Financial Incentive BEHAVIORAL

Randomly assigned patients to be entered into a drawing to receive a $100 gift card.

Arm 1 (Introductory Message A + Tobacco Use Message A + Incentive); Arm 11 (Introductory Message C + Tobacco Use Message B + Incentive); Arm 3 (Introductory Message A + Tobacco Use Message B + Incentive); Arm 5 (Introductory Message B + Tobacco Use Message A + Incentive); Arm 7 (Introductory Message B + Tobacco Use Message B + Incentive); Arm 9 (Introductory Message C + Tobacco Use Message A + Incentive)

Eligibility Criteria

• Age: 50 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• meet age eligibility (50-80 years old) for LCS based on 2021 USPSTF guidelines; and
• have completed at least one primary care visit at Penn Medicine in 2020-2025

You may not qualify if:

• have a documented history of lung cancer;
• have a documented history of completing LCS at Penn Medicine;
• are listed as not wanting to be contacted or solicited for research; or

Sponsors & Collaborators

• Abramson Cancer Center at Penn Medicine: lead
• National Institutes of Health (NIH): collaborator
• National Cancer Institute (NCI): collaborator

Study Sites (1)

University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

Location

MeSH Terms

Conditions

Lung Neoplasms

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Results Point of Contact

• Title: Katharine Rendle, PI
• Organization: University of Pennslyvania

katharine.rendle@pennmedicine.upenn.edu

215-349-5442

Study Officials

• Katharine A Rendle, PhD,MSW,MPH

  University of Pennsylvania

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: We will use a randomized factorial design to test the effects of different types of messaging with or without incentives on response rates to an eligibility survey.

Study Record Dates

• First Submitted: October 18, 2023
• First Posted: November 18, 2023
• Study Start: July 31, 2023
• Primary Completion: January 31, 2024
• Study Completion: January 31, 2024
• Last Updated: May 31, 2025
• Results First Posted: May 31, 2025

Record last verified: 2025-05

Locations

US (1)