Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of the Oncolytic HSV1 MVR-C5252

NCT06126744 | Recruiting Phase 1 DMC FDA Drug

• 1 other identifier: Pro00112883
• Study Type: interventional
• Target: 51
• Locations: 1 country
• Sites: 2

Brief Summary

This is a Phase 1 open label study designed to assess the safety and tolerability of the oncolytic herpes simplex virus 1 (oHSV1) study drug, MVR-C5252, administered intratumorally by convection-enhanced delivery (CED) in patients with recurrent high-grade glioma. Once the safety and maximum tolerated dose (MTD) is established in the dose escalation portion of the trial, a dose expansion cohort at the recommended phase 2 dose (RP2D) in patients with isocitrate dehydrogenase (IDH) wildtype recurrent glioblastoma (GBM) will evaluate preliminary efficacy of the study drug.

Conditions

Recurrent High Grade Glioma

Outcome Measures

Primary Outcomes (5)

• Stage 1: Proportion of patients with dose-limiting toxicity (DLT) during the single infusion

  Proportion of patients with dose-limiting toxicity (DLT) during the single infusion

  Day 1 of treatment until 28 days post first infusion

• Stage 2: Proportion of patients with dose-limiting toxicity (DLT) during 2 infusions using the internalized Ascenda catheter

  Proportion of patients with DLT who have received two infusions on days 1 and 28

  Day 1 of treatment until 28 days post second infusion for a total of up to 56 days post first infusion

• Stage 3a: Proportion of patients with dose-limiting toxicity (DLT) after each cycle with two infusions on days 1 and 8

  Proportion of patients with DLT who have received two infusions on days 1 and 8

  Day 1 of treatment until 28 days post second infusion for a total of up to 35 days post first infusion

• Stage 3b: Determine the MTD/RP2D

  Maximal Tolerated Dose/Recommended Phase 2 Dose (MTD/RP2D)

  Day 1 of treatment until 28 days post second infusion for a total of up to 35 days post first infusion for all the cycles for all the patients enrolled in stages 1, 2 and 3

• Stage 4: Progression Free Survival at 6 months

  Progression Free Survival at 6 months will be estimated by the Kaplan-Meier method

  Day 1 of treatment until first documentation of disease progression or date of death, whichever comes first, assessed up to 6 months

Secondary Outcomes (2)

• Overall Survival

  5 years

• Progression Free Survival

  5 years

Study Arms (1)

MVR-C5252

EXPERIMENTAL

Open label single arm infusion of MVR-C5252, genetically engineered type 1 oHSV (oncolytic herpes simplex viruses) into the tumor via Convection-enhanced delivery (CED) a modality that can bypass the BBB (Blood Brain Barrier), allowing the intracranial delivery through the BBB and avoiding systemic toxicities.

Biological: MVR-C5252

Interventions

MVR-C5252 BIOLOGICAL

MVR-C5252 is a genetically modified next generation oncolytic herpes simplex virus 1 (oHSV1) with an active domain of human IL-12 and Fab fragment of anti-PD-1 antibody. This is a Phase 1 open label study designed to determine the safety and tolerability of MVR-C5252. The dose-escalation portion of the study will be conducted in 4 stages to evaluate the safety of infusion and determination of the MTD/RP2D followed by efficacy assessment.

MVR-C5252

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age \>18 years of age
• Disease recurrence of at least 1x1cm and a maximum of 3x3cm of enhancing tumor:
• Dose escalation portion: patients with recurrent high-grade glioma, IDH wt or IDH mutated, grade 3 or grade 4 based on imaging.
• Dose expansion portion: Recurrent, IDH wt, glioblastoma, WHO grade 4. Diagnosis has be made using the 2021 WHO Classification of Tumors of the CNS.
• The neurosurgeon must confirm (a) the tumor location (\> 1 cm from eloquent brain), (b) that the placement of infusion catheter within or through the progressive enhancing tumor is feasible and is at a safe distance to eloquent brain function. These aspects will be determined prior catheter placement on the basis of prior (screening) MRI and then at the time of catheter placement on the basis of a CT scan prior to infusion. The tip of the catheter must be placed as follows:
• Within the enhancing portion or in the vicinity of enhancement of target lesion (i.e., infiltrative disease)
• ≥ 0.5 cm from ventricles
• ≥ 1 cm deep into the brain
• ≥ 0.5 cm from the corpus callosum
• If a histological or pathological confirmation of recurrence (\< 6 weeks) is not available, a pre-infusion biopsy will be required to confirm recurrence.
• Adequate pulmonary function, with a baseline pulse oximetry of at 90% on room air.
• The subject must have received standard radiation therapy plus temozolomide and be refractory to radiation therapy plus temozolomide prior to enrollment.
• Prior to administration of MVR-C5252, the presence of recurrent tumor must be confirmed by histopathological analysis. (Distinguishing between recurrent active tumor and radiation necrosis is important to avoid delivering MVR-C5252 when there is no active disease).
• Should participants have further surgical resection at any time following their participation in the study, patients will be invited to make any biospecimens available for correlative research.
• Karnofsky Performance Status (KPS) ≥ 70%

You may not qualify if:

• Prior, unrelated malignancy requiring current active treatment with the exception of cervical carcinoma in situ and adequately treated basal cell or squamous cell carcinoma of the skin
• Patients who are pregnant or breastfeeding
• Patients with contrast-enhancing tumor crossing the midline, multifocal tumor, infratentorial tumor, tumor in eloquent brain regions, extensive tumor dissemination (subependymal or leptomeningeal), or in unsafe brain regions per the opinion of the treating neurosurgeon
• Unstable systemic disease in the opinion of the treating physician.
• Active infection requiring systemic therapy or causing fever (temperature \> 38.1˚C) or subjects with unexplained fever (temperature \> 38.1˚C) within 7 days prior to the day of investigational product administration.
• Patients on \>4 mg per day of dexamethasone within the 2 weeks prior to admission for MVR-C5252 infusion or systemic therapy with immunosuppressive agents within 28 days prior to admission for MVR-C5252 infusion
• Patients who have not completed standard of care treatment prior to participation in this trial
• Less than 12 weeks from radiation therapy, unless progressive disease outside of the radiation field or 2 progressive scans at least 4 weeks apart or histopathologic confirmation of recurrent tumor
• Treated with immunotherapeutic agents prior to MVR-C5252 treatment, within 4 weeks, alkylating agents within 4 weeks, nitrosoureas within 6 weeks, or non-alkylating chemotherapy within 2 weeks before enrollment, unless the patient has recovered from the expected toxic effects of such therapy
• Treated with antiangiogenic agents (i.e., bevacizumab) within 4 weeks before biopsy
• Patients who require an attenuated or live vaccine within 28 days prior to the first trial drug administration and during the study treatment period
• Prior treatment with any oncolytic virus, cell therapy or gene therapy.
• Prior antitumor treatment with intracranial implants, such as Carmustine
• Previous history of allergic reactions to similar biological components such as HSV-1, IL-12 or anti-PD-1 antibodies, or with known allergic reactions to any component of the MVR-C5252 prescription, including glycerol.
• Systemic use (other than topical) of anti-HSV drugs (including, but not limited to, acyclovir, valaciclovir, penciclovir, famciclovir, ganciclovir, foscarnet, cidofovir, etc.)

Sponsors & Collaborators

• Duke University: lead

Study Sites (2)

Memorial Sloan Kettering

New York, New York, 10065, United States

RECRUITING

Duke University

Durham, North Carolina, 27750, United States

RECRUITING

MeSH Terms

Conditions

Glioma

Condition Hierarchy (Ancestors)

Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue

Central Study Contacts

Mustafa Khasraw, MD

CONTACT

919 684 5301; mustafa.khasraw@duke.edu

Stieve Threatt

CONTACT

919-684-5301; dukebrain1@duke.edu

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SEQUENTIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Neurosurgery

Study Record Dates

• First Submitted: September 24, 2023
• First Posted: November 13, 2023
• Study Start: June 11, 2024
• Primary Completion (Estimated): December 1, 2027
• Study Completion (Estimated): December 1, 2028
• Last Updated: April 15, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (2)