Analyzing the Changes in Eye Axis Length and Corneal Curvature in Central China

NCT06126302 | Unknown

• 1 other identifier: 20231105
• Study Type: observational
• Target: 60,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

The Chinese lifestyle has undergone dramatic changes over the past century. In recent years, limited studies reported the changing trend in crucial eye parameters of people born in different decades. This multicenter study analyzed the axial length and average corneal curvature data from patients of four hospital. The trends in the axial length and corneal curvature will be observed.

Conditions

Birth Year-dependent Eye Parameters Change

Keywords

Eye axial length; Corneal curvature; Birth year-dependent

Outcome Measures

Primary Outcomes (2)

• Eye Axial Length

  The Axial length of all patients were measured using the IOL Master 5.5 (Carl Zeiss Meditec, Dublin, CA) biometry system for routine examination of cataracts or refractive examination (ametropia and presbyopia).AL was measured as the distance from the tear film to the retinal pigment epithelium. The mean of 5 measurements wasas taken for final analyses.

  2023/10

• Corneal Curvature

  The corneal curvature of all patients were measured using the IOL Master 5.5 (Carl Zeiss Meditec, Dublin, CA) biometry system for routine examination of cataracts or refractive examination (ametropia and presbyopia). Corneal curvature was measured in two meridians: flat keratometry (K1) and steep K (K2). The K value was the mean of K1 and K2. Corneal curvature was measured at least three times. In case of variations in values, measurements were repeated until reproducible results were obtained.

  2023/10

Study Arms (10)

Before 1930

the patients were divided into ten groups according to the decade of their birth: before 1930

Other: Birth year

1930-1939

the patients were divided into ten groups according to the decade of their birth: 1930-1939

Other: Birth year

1940-1949

the patients were divided into ten groups according to the decade of their birth: 1940-1949

Other: Birth year

1950-1959

the patients were divided into ten groups according to the decade of their birth: 1950-1959

Other: Birth year

1960-1969

the patients were divided into ten groups according to the decade of their birth: 1960-1969

Other: Birth year

1970-1979

the patients were divided into ten groups according to the decade of their birth: 1970-1979

Other: Birth year

1980-1989

the patients were divided into ten groups according to the decade of their birth: 1980-1989

Other: Birth year

1990-1999

the patients were divided into ten groups according to the decade of their birth: 1990-1999

Other: Birth year

2000-2009

the patients were divided into ten groups according to the decade of their birth: 2000-2009

Other: Birth year

after 2009

the patients were divided into ten groups according to the decade of their birth: after 2009

Other: Birth year

Interventions

Birth year OTHER

we divided the patients according to patients' birth year

1930-1939; 1940-1949; 1950-1959; 1960-1969; 1970-1979; 1980-1989; 1990-1999; 2000-2009; Before 1930; after 2009

Eligibility Criteria

• Age: 7 Years - 130 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Eligible patients were those aged ≥7 years and who underwent intraocular lens (IOL) Master (version 5.5) biometry for routine examination of cataract or refractive examination (ametropia and presbyopia) between April 2012 and November October 2023.

You may qualify if:

• \- Eligible patients were those aged ≥7 years and who underwent intraocular lens (IOL) Master (version 5.5) biometry for routine examination of cataract or refractive examination (ametropia and presbyopia) between April 2012 and November October 2023. Only patients who would cooperate with examinations to ensure stable and repeatable data (AL was measured 5 times or more, CC was measured 3 times or more, and the coefficient of variation of the measured results were≤15%a coefficient of variation ≤15% was considered low variation) were selected.

Sponsors & Collaborators

• Min Ke: lead

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Department of ophthalmology, Zhongnan Hospital

Study Record Dates

• First Submitted: November 6, 2023
• First Posted: November 13, 2023
• Study Start: November 5, 2023
• Primary Completion: November 10, 2023
• Study Completion: November 20, 2023
• Last Updated: November 13, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share