NCT06126055

Brief Summary

GERD is a chronic disease the require different treatment modalities; non have proven long term efficacy with concerns about their safety. The use of band ligation in endoscopy appears safe, repeatable with short learning curve. Placing multiple bands at the Z-line can create a fibrous ring in the distal esophagus acting as a barrier against reflux of gastric content.

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
10

participants targeted

Target at below P25 for not_applicable

Timeline
19mo left

Started Dec 2025

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress22%
Dec 2025Dec 2027

First Submitted

Initial submission to the registry

November 3, 2023

Completed
10 days until next milestone

First Posted

Study publicly available on registry

November 13, 2023

Completed
2.1 years until next milestone

Study Start

First participant enrolled

December 1, 2025

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2027

Last Updated

August 8, 2025

Status Verified

August 1, 2025

Enrollment Period

2 years

First QC Date

November 3, 2023

Last Update Submit

August 5, 2025

Conditions

GERD

Keywords

GERDGastroEsophageal RefluxBand LigationEndoBand

Outcome Measures

Primary Outcomes (1)

  • Endoscopic Band Ligation for GERD

    Resolution of reflux symptoms and stopping proton pump inhibitors.

    1 month

Study Arms (1)

Off PPI

EXPERIMENTAL

No symptoms of reflux

Device: Band Ligation

Interventions

Band LigationDEVICE

Placing bands in distal esophagus

Off PPI

Eligibility Criteria

Age18 Years - 50 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Symptomatic GERD

You may not qualify if:

  • Any previous surgery for GERD

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Endoscopy Unit Cairo University

Cairo, Egypt

Location

MeSH Terms

Conditions

Gastroesophageal Reflux

Condition Hierarchy (Ancestors)

Esophageal Motility DisordersDeglutition DisordersEsophageal DiseasesGastrointestinal DiseasesDigestive System Diseases

Study Officials

  • Mohamed Abeid, MD

    Endoscopy Unit Faculty of Medicine Cairo University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Mohamed Abeid, MD

CONTACT

+201001222254mohamedabeid@gmail.com

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Consultant Gastroenterologist

Study Record Dates

First Submitted

November 3, 2023

First Posted

November 13, 2023

Study Start

December 1, 2025

Primary Completion (Estimated)

December 1, 2027

Study Completion (Estimated)

December 1, 2027

Last Updated

August 8, 2025

Record last verified: 2025-08

Data Sharing

IPD Sharing
Will share

Yes

Shared Documents
STUDY PROTOCOL
Time Frame
1 year
Access Criteria
Free
More information

Locations

EG(1)